Variation in the COMT gene: implications for pain perception and pain treatment (Q37448922)

20 August 2017

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title

Variation in the COMT gene: implications for pain perception and pain treatment (English)

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20 August 2017

2

Frank Skorpen

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20 August 2017

Sonja Andersen

1

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20 August 2017

1 April 2009

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20 August 2017

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20 August 2017

10

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20 August 2017

669-684

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20 August 2017

4

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Biochemical and molecular modeling studies of the O-methylation of various endogenous and exogenous catechol substrates catalyzed by recombinant human soluble and membrane-bound catechol-O-methyltransferases.

20 August 2017

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COMT val158met genotype affects mu-opioid neurotransmitter responses to a pain stressor

21 January 2018

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Catechol-O-methyltransferase gene haplotypes in Mexican and Spanish patients with fibromyalgia

21 January 2018

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Significance of the catechol-O-methyltransferase gene polymorphism in migraine

21 January 2018

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The Val158Met polymorphism of the human catechol-O-methyltransferase (COMT) gene may influence morphine requirements in cancer pain patients

21 January 2018

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Genomic organization of the human catechol O-methyltransferase gene and its expression from two distinct promoters.

21 January 2018

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Structure of the rat catechol-O-methyltransferase gene: separate promoters are used to produce mRNAs for soluble and membrane-bound forms of the enzyme

21 January 2018

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Human catechol-O-methyltransferase: cloning and expression of the membrane-associated form

21 January 2018

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Cloning and Characterization of Human Placental Catechol--Methyltransferase cDNA

21 January 2018

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Production of rat soluble and membrane-bound catechol O-methyltransferase forms from bifunctional mRNAs

21 January 2018

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Distribution of catechol-O-methyltransferase expression in human central nervous system.

21 January 2018

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Catechol O-methyltransferase mRNA expression in human and rat brain: evidence for a role in cortical neuronal function

21 January 2018

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Expression of multiple catechol-o-methyltransferase (COMT) mRNA variants in human brain.

21 January 2018

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Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): effects on mRNA, protein, and enzyme activity in postmortem human brain

21 January 2018

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Kinetics of human soluble and membrane-bound catechol O-methyltransferase: a revised mechanism and description of the thermolabile variant of the enzyme

21 January 2018

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Expression and intracellular localization of catechol O-methyltransferase in transfected mammalian cells.

21 January 2018

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Immunohistochemical demonstration of catechol-O-methyltransferase in mammalian brain

21 January 2018

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Immunohistochemical study of catechol-O-methyltransferase in the human mesostriatal system

21 January 2018

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3-Methoxytyramine Is the Major Metabolite of Released Dopamine in the Rat Frontal Cortex: Reassessment of the Effects of Antipsychotics on the Dynamics of Dopamine Release and Metabolism in the Frontal Cortex, Nucleus Accumbens, and Striatum by a Sim

21 January 2018

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Catechol-O-methyltransferase-deficient mice exhibit sexually dimorphic changes in catecholamine levels and behavior

21 January 2018

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Site-specific role of catechol-O-methyltransferase in dopamine overflow within prefrontal cortex and dorsal striatum

21 January 2018

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Catechol-o-methyltransferase inhibition improves set-shifting performance and elevates stimulated dopamine release in the rat prefrontal cortex

21 January 2018

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Dopamine transporter immunoreactivity in monkey cerebral cortex: regional, laminar, and ultrastructural localization

21 January 2018

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Pharmacogenomics: catechol O-methyltransferase to thiopurine S-methyltransferase

21 January 2018

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Human catechol O-methyltransferase genetic variation: gene resequencing and functional characterization of variant allozymes

21 January 2018

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The structure of haplotype blocks in the human genome

21 January 2018

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Human catechol-O-methyltransferase haplotypes modulate protein expression by altering mRNA secondary structure.

21 January 2018

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Noradrenergic pain modulation

21 January 2018

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Sympathetic activation triggers endogenous opioid release and analgesia within peripheral inflamed tissue

21 January 2018

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Perioperative administration of the α2-adrenoceptor agonist clonidine at the site of nerve injury reduces the development of mechanical hypersensitivity and modulates local cytokine expression

21 January 2018

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Perineural clonidine reduces mechanical hypersensitivity and cytokine production in established nerve injury

21 January 2018

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Alpha2-adrenoceptor stimulation transforms immune responses in neuritis and blocks neuritis-induced pain.

21 January 2018

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Descending control of pain

21 January 2018

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Functional interactions between mu opioid and alpha 2A-adrenergic receptors.

21 January 2018

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Structure and function of dopamine receptors

21 January 2018

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The catechol-O-methyltransferase polymorphism: relations to the tonic-phasic dopamine hypothesis and neuropsychiatric phenotypes

21 January 2018

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Role of central dopamine in pain and analgesia

21 January 2018

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Continuous treatment with the D2 dopamine receptor agonist quinpirole decreases D2 dopamine receptors, D2 dopamine receptor messenger RNA and proenkephalin messenger RNA, and increases mu opioid receptors in mouse striatum

21 January 2018

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Role of dynorphin and enkephalin in the regulation of striatal output pathways and behavior

21 January 2018

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Evidence for a biopsychosocial influence on shoulder pain: pain catastrophizing and catechol-O-methyltransferase (COMT) diplotype predict clinical pain ratings.

21 January 2018

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No association between chronic musculoskeletal complaints and Val158Met polymorphism in the Catechol-O-methyltransferase gene. The HUNT study

21 January 2018

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The association between headache and Val158Met polymorphism in the catechol-O-methyltransferase gene: the HUNT Study

21 January 2018

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COMT (Val158Met) polymorphism is not associated to neuropathic pain in a Spanish population

21 January 2018

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Genetic influence on variability in human acute experimental pain sensitivity associated with gender, ethnicity and psychological temperament.

21 January 2018

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Genetic predictors for acute experimental cold and heat pain sensitivity in humans

21 January 2018

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Genetic polymorphisms in monoamine neurotransmitter systems show only weak association with acute post-surgical pain in humans

21 January 2018

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Genetic variation and response to morphine in cancer patients: catechol-O-methyltransferase and multidrug resistance-1 gene polymorphisms are associated with central side effects

21 January 2018

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Catechol-O-methyltransferase inhibition increases pain sensitivity through activation of both beta2- and beta3-adrenergic receptors

21 January 2018

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Organization of Endogenous Opiate and Nonopiate Pain Control Systems

21 January 2018

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Genetic dissection of the role of catechol-O-methyltransferase in cognition and stress reactivity in mice

21 January 2018

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Beta2 adrenergic receptor activation stimulates pro-inflammatory cytokine production in macrophages via PKA- and NF-kappaB-independent mechanisms.

21 January 2018

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Recent findings on how proinflammatory cytokines cause pain: peripheral mechanisms in inflammatory and neuropathic hyperalgesia.

21 January 2018

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No gene is an island: the flip-flop phenomenon

21 January 2018

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Global variation in the frequencies of functionally different catechol-O-methyltransferase alleles.

21 January 2018

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21 January 2018

Race, ethnicity and pain

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Genes mirror geography within Europe

21 January 2018

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Why most published research findings are false

21 January 2018

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Chapter 13 Descending inhibitory systems

21 January 2018

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21 January 2018

Identifiers

DOI

10.2217/PGS.09.13

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20 August 2017

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PubMed ID

19374521