Y-family DNA polymerases in mammalian cells (Q37444742)

20 August 2017

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title

Y-family DNA polymerases in mammalian cells (English)

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20 August 2017

Caixia Guo

1

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20 August 2017

J Nicole Kosarek-Stancel

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2

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20 August 2017

Tie-Shan Tang

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3

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20 August 2017

Errol C Friedberg

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4

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20 August 2017

15 April 2009

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Cellular and Molecular Life Sciences

20 August 2017

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20 August 2017

66

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20 August 2017

2363-2381

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20 August 2017

14

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https://scigraph.springernature.com/pub.10.1007/s00018-009-0024-4

20 August 2017

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cites work

Translesion synthesis of 7,8-dihydro-8-oxo-2'-deoxyguanosine by DNA polymerase eta in vivo

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https://api.crossref.org/works/10.1007%2FS00018-009-0024-4

Efficiency, specificity and DNA polymerase-dependence of translesion replication across the oxidative DNA lesion 8-oxoguanine in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-009-0024-4

poliota-dependent lesion bypass in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-009-0024-4

The BRCA1 C-terminal domain: structure and function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-009-0024-4

Proficient and accurate bypass of persistent DNA lesions by DinB DNA polymerases

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-009-0024-4

Activation of ubiquitin-dependent DNA damage bypass is mediated by replication protein a.

21 January 2018

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12 December 2020

8-oxo-guanine bypass by human DNA polymerases in the presence of auxiliary proteins

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12 December 2020

The human REV1 gene codes for a DNA template-dependent dCMP transferase

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12 December 2020

REV1 accumulates in DNA damage-induced nuclear foci in human cells and is implicated in mutagenesis by benzo[a]pyrenediolepoxide

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12 December 2020

An incoming nucleotide imposes an anti to syn conformational change on the templating purine in the human DNA polymerase-iota active site

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12 December 2020

Elevated mutation rates in the germline of Polkappa mutant male mice

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12 December 2020

Crystal structure of the catalytic core of human DNA polymerase kappa

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12 December 2020

p21 differentially regulates DNA replication and DNA-repair-associated processes after UV irradiation.

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12 December 2020

Xeroderma pigmentosum variant (XP-V) correcting protein from HeLa cells has a thymine dimer bypass DNA polymerase activity

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12 December 2020

DNA polymerase kappa is specifically required for recovery from the benzo[a]pyrene-dihydrodiol epoxide (BPDE)-induced S-phase checkpoint

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12 December 2020

DNA polymerase eta is the sole contributor of A/T modifications during immunoglobulin gene hypermutation in the mouse

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12 December 2020

Characterization of promoter regulatory elements involved in downexpression of the DNA polymerase kappa in colorectal cancer

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12 December 2020

PTIP/Swift is required for efficient PCNA ubiquitination in response to DNA damage

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12 December 2020

Error-free and error-prone lesion bypass by human DNA polymerase kappa in vitro

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12 December 2020

The Saccharomyces cerevisiae RAD30 gene, a homologue of Escherichia coli dinB and umuC, is DNA damage inducible and functions in a novel error-free postreplication repair mechanism

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12 December 2020

DNA polymerase eta is an A-T mutator in somatic hypermutation of immunoglobulin variable genes

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12 December 2020

Mutation enhancement by DINB1, a mammalian homologue of the Escherichia coli mutagenesis protein dinB

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12 December 2020

129-derived strains of mice are deficient in DNA polymerase iota and have normal immunoglobulin hypermutation

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12 December 2020

Localisation of human DNA polymerase kappa to replication foci

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12 December 2020

Database of mouse strains carrying targeted mutations in genes affecting biological responses to DNA damage Version 7

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12 December 2020

Purification and characterization of pol kappa, a DNA polymerase encoded by the human DINB1 gene

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12 December 2020

Altered DNA polymerase iota expression in breast cancer cells leads to a reduction in DNA replication fidelity and a higher rate of mutagenesis

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12 December 2020

Analyses of ultraviolet-induced focus formation of hREV1 protein.

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12 December 2020

DNA polymerase iota and related rad30-like enzymes

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12 December 2020

Human and mouse homologs of Escherichia coli DinB (DNA polymerase IV), members of the UmuC/DinB superfamily

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12 December 2020

Localisation of human Y-family DNA polymerase kappa: relationship to PCNA foci.

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12 December 2020

Mouse Rev1 protein interacts with multiple DNA polymerases involved in translesion DNA synthesis

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12 December 2020

Interaction of human DNA polymerase eta with monoubiquitinated PCNA: a possible mechanism for the polymerase switch in response to DNA damage

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12 December 2020

Induction of somatic hypermutation in immunoglobulin genes is dependent on DNA polymerase iota.

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12 December 2020

Cellular functions of DNA polymerase zeta and Rev1 protein

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12 December 2020

The role of DNA polymerase eta in translesion synthesis past platinum-DNA adducts in human fibroblasts

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12 December 2020

DNA polymerase kappa deficiency does not affect somatic hypermutation in mice

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12 December 2020

Genetic linkage between Pol iota deficiency and increased susceptibility to lung tumors in mice

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12 December 2020

Werner syndrome protein interacts functionally with translesion DNA polymerases

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12 December 2020

Human cancers express a mutator phenotype

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12 December 2020

Error-prone bypass of certain DNA lesions by the human DNA polymerase kappa

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12 December 2020

Human DNA polymerase eta activity and translocation is regulated by phosphorylation

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12 December 2020

Regulation of polymerase exchange between Poleta and Poldelta by monoubiquitination of PCNA and the movement of DNA polymerase holoenzyme

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12 December 2020

Polkappa protects mammalian cells against the lethal and mutagenic effects of benzo[a]pyrene

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12 December 2020

Translesion synthesis: Y-family polymerases and the polymerase switch

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12 December 2020

Analysis of lung tumorigenesis in chimeric mice indicates the Pulmonary adenoma resistance 2 (Par2) locus to operate in the tumor-initiation stage in a cell-autonomous manner: detection of polymorphisms in the Poli gene as a candidate for Par2.

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12 December 2020

Deoxycytidyl transferase activity of the human REV1 protein is closely associated with the conserved polymerase domain

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12 December 2020

The function of the human homolog of Saccharomyces cerevisiae REV1 is required for mutagenesis induced by UV light

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12 December 2020

Control of spontaneous and damage-induced mutagenesis by SUMO and ubiquitin conjugation

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12 December 2020

Efficient translesion replication past oxaliplatin and cisplatin GpG adducts by human DNA polymerase eta.

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12 December 2020

Mechanisms of dCMP transferase reactions catalyzed by mouse Rev1 protein

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12 December 2020

Lesion Bypass of N2-Ethylguanine by Human DNA Polymerase ι

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12 December 2020

Efficiency, fidelity and enzymatic switching during translesion DNA synthesis

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12 December 2020

DNA polymerase-eta as a reverse transcriptase: implications for mechanisms of hypermutation in innate anti-retroviral defences and antibody SHM systems.

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12 December 2020

A single domain in human DNA polymerase iota mediates interaction with PCNA: implications for translesion DNA synthesis

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12 December 2020

Association of amino acid substitution polymorphisms in DNA repair genes TP53, POLI, REV1 and LIG4 with lung cancer risk.

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12 December 2020

Biochemical characterization of human DNA polymerase iota provides clues to its biological function.

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12 December 2020

Localization of the deoxyribose phosphate lyase active site in human DNA polymerase iota by controlled proteolysis.

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12 December 2020

Human DNA polymerase kappa encircles DNA: implications for mismatch extension and lesion bypass

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12 December 2020

poliota, a remarkably error-prone human DNA polymerase

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12 December 2020

DNA polymerase eta is involved in hypermutation occurring during immunoglobulin class switch recombination.

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12 December 2020

Contribution of DNA polymerase eta to immunoglobulin gene hypermutation in the mouse

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12 December 2020

Quantitative analysis of translesion DNA synthesis across a benzo[a]pyrene-guanine adduct in mammalian cells: the role of DNA polymerase kappa

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12 December 2020

Rad18 regulates DNA polymerase kappa and is required for recovery from S-phase checkpoint-mediated arrest

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12 December 2020

Role of single-stranded DNA in targeting REV1 to primer termini

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12 December 2020

Ubiquitylation of yeast proliferating cell nuclear antigen and its implications for translesion DNA synthesis

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12 December 2020

trans-Lesion synthesis past bulky benzo[a]pyrene diol epoxide N2-dG and N6-dA lesions catalyzed by DNA bypass polymerases

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12 December 2020

Unique misinsertion specificity of poliota may decrease the mutagenic potential of deaminated cytosines

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12 December 2020

Interactions in the error-prone postreplication repair proteins hREV1, hREV3, and hREV7

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12 December 2020

Ubiquitination of PCNA and the polymerase switch in human cells

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12 December 2020

Requirements for the interaction of mouse Polkappa with ubiquitin and its biological significance

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12 December 2020

Normal hypermutation in antibody genes from congenic mice defective for DNA polymerase iota.

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12 December 2020

A dynamic ubiquitin equilibrium couples proteasomal activity to chromatin remodeling

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12 December 2020

REV1 genetic variants associated with the risk of cervical carcinoma

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12 December 2020

Constitutive and regulated expression of the mouse Dinb (Polkappa) gene encoding DNA polymerase kappa.

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12 December 2020

Interaction of hREV1 with three human Y-family DNA polymerases

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12 December 2020

Suffering in silence: the tolerance of DNA damage

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12 December 2020

Replication by human DNA polymerase-iota occurs by Hoogsteen base-pairing

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12 December 2020

Crystal structure of a Y-family DNA polymerase in action: a mechanism for error-prone and lesion-bypass replication

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12 December 2020

Proteasome inhibitors remarkably prevent translesion replication in cancer cells but not normal cells

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12 December 2020

Translesion DNA replication proteins as molecular targets for cancer prevention

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12 December 2020

Replication-dependent and -independent responses of RAD18 to DNA damage in human cells

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12 December 2020

DNA damage-induced ubiquitylation of RFC2 subunit of replication factor C complex

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12 December 2020

Adaptation to DNA damage and stimulation of genetic instability: the double-edged sword mammalian DNA polymerase kappa

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12 December 2020

REV1 restrains DNA polymerase zeta to ensure frame fidelity during translesion synthesis of UV photoproducts in vivo

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12 December 2020

Misinsertion and bypass of thymine-thymine dimers by human DNA polymerase iota

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12 December 2020

Rad6-Rad18 mediates a eukaryotic SOS response by ubiquitinating the 9-1-1 checkpoint clamp.

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12 December 2020

Regulation of monoubiquitinated PCNA by DUB autocleavage

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12 December 2020

Expression of human and mouse genes encoding polkappa: testis-specific developmental regulation and AhR-dependent inducible transcription

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12 December 2020

Increased susceptibility to UV-induced skin carcinogenesis in polymerase eta-deficient mice.

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12 December 2020

Domain structure, localization, and function of DNA polymerase eta, defective in xeroderma pigmentosum variant cells

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12 December 2020

The Fanconi anemia core complex is required for efficient point mutagenesis and Rev1 foci assembly

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12 December 2020

Mutation frequencies and spectra in DNA polymerase eta-deficient mice

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12 December 2020

Hypoxia-inducible factor-1 mediates the expression of DNA polymerase iota in human tumor cells

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12 December 2020

REV1 mediated mutagenesis in base excision repair deficient mouse fibroblast.

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12 December 2020

Involvement of vertebrate Polkappa in translesion DNA synthesis across DNA monoalkylation damage

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12 December 2020

DNA polymerase theta contributes to the generation of C/G mutations during somatic hypermutation of Ig genes

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12 December 2020

Xeroderma pigmentosum: variants with normal DNA repair and normal sensitivity to ultraviolet light

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12 December 2020

Different mutation signatures in DNA polymerase eta- and MSH6-deficient mice suggest separate roles in antibody diversification

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12 December 2020

The Y-family DNA polymerase kappa (pol kappa) functions in mammalian nucleotide-excision repair

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12 December 2020

Interaction with DNA polymerase eta is required for nuclear accumulation of REV1 and suppression of spontaneous mutations in human cells.

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12 December 2020

Structure and enzymatic properties of a stable complex of the human REV1 and REV7 proteins

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12 December 2020

DNA polymerase eta undergoes alternative splicing, protects against UV sensitivity and apoptosis, and suppresses Mre11-dependent recombination

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12 December 2020

Ubiquitin-binding motifs in REV1 protein are required for its role in the tolerance of DNA damage

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12 December 2020

Regulated proteolysis of DNA polymerase eta during the DNA-damage response in C. elegans

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12 December 2020

Eukaryotic polymerases iota and zeta act sequentially to bypass DNA lesions

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12 December 2020

Novel human and mouse homologs of Saccharomyces cerevisiae DNA polymerase eta

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12 December 2020

Novel conserved motifs in Rev1 C-terminus are required for mutagenic DNA damage tolerance

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12 December 2020

Rad18 guides poleta to replication stalling sites through physical interaction and PCNA monoubiquitination

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12 December 2020

Preferential misincorporation of purine nucleotides by human DNA polymerase eta opposite benzo[a]pyrene 7,8-diol 9,10-epoxide deoxyguanosine adducts

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12 December 2020

Multiple Mechanisms Control Chromosome Integrity after Replication Fork Uncoupling and Restart at Irreparable UV Lesions

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12 December 2020

Regulation of proliferating cell nuclear antigen ubiquitination in mammalian cells

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12 December 2020

Ubiquitinated proliferating cell nuclear antigen activates translesion DNA polymerases eta and REV1

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12 December 2020

Stimulation of DNA synthesis activity of human DNA polymerase kappa by PCNA.

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12 December 2020

Cellular roles of DNA polymerase zeta and Rev1 protein

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12 December 2020

Ubiquitylated PCNA plays a role in somatic hypermutation and class-switch recombination and is required for meiotic progression

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12 December 2020

RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO.

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12 December 2020

Multiple roles of vertebrate REV genes in DNA repair and recombination

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12 December 2020

Physical and functional interactions of human DNA polymerase eta with PCNA

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12 December 2020

Human DNA polymerase eta promotes DNA synthesis from strand invasion intermediates of homologous recombination

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12 December 2020

A ubiquitin-binding motif in the translesion DNA polymerase Rev1 mediates its essential functional interaction with ubiquitinated proliferating cell nuclear antigen in response to DNA damage

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12 December 2020

Rev1 employs a novel mechanism of DNA synthesis using a protein template

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12 December 2020

Increased ultraviolet sensitivity and chromosomal instability related to P53 function in the xeroderma pigmentosum variant

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12 December 2020

The Fanconi anaemia gene FANCC promotes homologous recombination and error-prone DNA repair

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12 December 2020

DNA polymerase eta, the product of the xeroderma pigmentosum variant gene and a target of p53, modulates the DNA damage checkpoint and p53 activation.

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12 December 2020

Chk1 and Claspin potentiate PCNA ubiquitination

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12 December 2020

The Y-family of DNA polymerases

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12 December 2020

Eukaryotic translesion synthesis DNA polymerases: specificity of structure and function

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12 December 2020

Proliferating cell nuclear antigen-dependent coordination of the biological functions of human DNA polymerase iota.

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12 December 2020

Trading places: how do DNA polymerases switch during translesion DNA synthesis?

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12 December 2020

Translesion synthesis across bulky N2-alkyl guanine DNA adducts by human DNA polymerase kappa

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12 December 2020

Multiple PolK (POLK) transcripts in mammalian testis.

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12 December 2020

Regulation of Saccharomyces cerevisiae DNA polymerase eta transcript and protein.

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12 December 2020

Efficient bypass of a thymine-thymine dimer by yeast DNA polymerase, Poleta

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12 December 2020

P21Cip1/WAF1 downregulation is required for efficient PCNA ubiquitination after UV irradiation.

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12 December 2020

A/T mutagenesis in hypermutated immunoglobulin genes strongly depends on PCNAK164 modification

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12 December 2020

What a difference a decade makes: insights into translesion DNA synthesis

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12 December 2020

Error-Prone DNA Polymerases: When Making a Mistake is the Only Way to Get Ahead

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12 December 2020

Up-regulation of the error-prone DNA polymerase {kappa} promotes pleiotropic genetic alterations and tumorigenesis.

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12 December 2020

Strand-biased defect in C/G transversions in hypermutating immunoglobulin genes in Rev1-deficient mice

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12 December 2020

Contributions of ubiquitin- and PCNA-binding domains to the activity of Polymerase eta in Saccharomyces cerevisiae

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12 December 2020

Effect of proliferating cell nuclear antigen ubiquitination and chromatin structure on the dynamic properties of the Y-family DNA polymerases

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12 December 2020

The translesion DNA polymerase theta plays a dominant role in immunoglobulin gene somatic hypermutation

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12 December 2020

Two-polymerase mechanisms dictate error-free and error-prone translesion DNA synthesis in mammals

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12 December 2020

Evidence that in xeroderma pigmentosum variant cells, which lack DNA polymerase eta, DNA polymerase iota causes the very high frequency and unique spectrum of UV-induced mutations

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12 December 2020

The translesion DNA polymerase zeta plays a major role in Ig and bcl-6 somatic hypermutation.

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12 December 2020

Human DNA polymerase iota protects cells against oxidative stress

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12 December 2020

Altered nucleotide misinsertion fidelity associated with poliota-dependent replication at the end of a DNA template.

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12 December 2020

Preferential incorporation of G opposite template T by the low-fidelity human DNA polymerase iota

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12 December 2020

Controlling the subcellular localization of DNA polymerases iota and eta via interactions with ubiquitin

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12 December 2020

Human DNA polymerase kappa bypasses and extends beyond thymine glycols during translesion synthesis in vitro, preferentially incorporating correct nucleotides

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12 December 2020

Genomic structure, chromosomal localization and identification of mutations in the xeroderma pigmentosum variant (XPV) gene

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12 December 2020

Pol iota is a candidate for the mouse pulmonary adenoma resistance 2 locus, a major modifier of chemically induced lung neoplasia.

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12 December 2020

Preferential cis-syn thymine dimer bypass by DNA polymerase eta occurs with biased fidelity.

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12 December 2020

REV1 protein interacts with PCNA: significance of the REV1 BRCT domain in vitro and in vivo

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12 December 2020

Polymerase eta and p53 jointly regulate cell survival, apoptosis and Mre11 recombination during S phase checkpoint arrest after UV irradiation

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12 December 2020

Comparative analysis of in vivo interactions between Rev1 protein and other Y-family DNA polymerases in animals and yeasts

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12 December 2020

Participation of mouse DNA polymerase iota in strand-biased mutagenic bypass of UV photoproducts and suppression of skin cancer

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12 December 2020

Translesion synthesis past estrogen-derived DNA adducts by human DNA polymerases eta and kappa

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12 December 2020

Response of human DNA polymerase iota to DNA lesions

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12 December 2020

Evidence for a second function for Saccharomyces cerevisiae Rev1p

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12 December 2020

Efficient and accurate replication in the presence of 7,8-dihydro-8-oxoguanine by DNA polymerase eta.

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12 December 2020

Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis

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12 December 2020

Normal immunoglobulin gene somatic hypermutation in Pol kappa-Pol iota double-deficient mice

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12 December 2020

Co-localization in replication foci and interaction of human Y-family members, DNA polymerase pol eta and REVl protein

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12 December 2020

The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase eta

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12 December 2020

Monoubiquitination of proliferating cell nuclear antigen induced by stalled replication requires uncoupling of DNA polymerase and mini-chromosome maintenance helicase activities.

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12 December 2020

Mutagenic and nonmutagenic bypass of DNA lesions by Drosophila DNA polymerases dpoleta and dpoliota.

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12 December 2020

The BRCT domain of mammalian Rev1 is involved in regulating DNA translesion synthesis

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12 December 2020

Damage repair DNA polymerases Y.

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12 December 2020

Gaps and forks in DNA replication: Rediscovering old models

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12 December 2020

Structure of the catalytic core of S. cerevisiae DNA polymerase eta: implications for translesion DNA synthesis

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12 December 2020

Translesion DNA synthesis in eukaryotes: a one- or two-polymerase affair

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12 December 2020

5'-Deoxyribose phosphate lyase activity of human DNA polymerase iota in vitro

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12 December 2020

Vertebrate DNA damage tolerance requires the C-terminus but not BRCT or transferase domains of REV1

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12 December 2020

Yeast Rev1 is cell cycle regulated, phosphorylated in response to DNA damage and its binding to chromosomes is dependent upon MEC1

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12 December 2020

Roles of PCNA-binding and ubiquitin-binding domains in human DNA polymerase eta in translesion DNA synthesis

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12 December 2020

Identification of a novel REV1-interacting motif necessary for DNA polymerase kappa function.

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12 December 2020

Ribozyme-mediated REV1 inhibition reduces the frequency of UV-induced mutations in the human HPRT gene

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12 December 2020

Localization of DNA polymerases eta and iota to the replication machinery is tightly co-ordinated in human cells.

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12 December 2020

UV-B radiation induces epithelial tumors in mice lacking DNA polymerase eta and mesenchymal tumors in mice deficient for DNA polymerase iota

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12 December 2020

hREV3 is essential for error-prone translesion synthesis past UV or benzo[a]pyrene diol epoxide-induced DNA lesions in human fibroblasts

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12 December 2020

The critical mutagenic translesion DNA polymerase Rev1 is highly expressed during G(2)/M phase rather than S phase

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12 December 2020

Rev1 is essential for DNA damage tolerance and non-templated immunoglobulin gene mutation in a vertebrate cell line.

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12 December 2020

A human DNA polymerase eta complex containing Rad18, Rad6 and Rev1; proteomic analysis and targeting of the complex to the chromatin-bound fraction of cells undergoing replication fork arrest

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12 December 2020

DNA polymerase kappa, implicated in spontaneous and DNA damage-induced mutagenesis, is overexpressed in lung cancer.

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12 December 2020

PCNA ubiquitination and REV1 define temporally distinct mechanisms for controlling translesion synthesis in the avian cell line DT40.

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12 December 2020

Dual roles for DNA polymerase eta in homologous DNA recombination and translesion DNA synthesis

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12 December 2020

Polymerase eta is a short-lived, proteasomally degraded protein that is temporarily stabilized following UV irradiation in Saccharomyces cerevisiae

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12 December 2020

10.1007/S00018-009-0024-4

Identifiers

DOI

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20 August 2017

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