Phenoxy herbicides and fibrates potently inhibit the human chemosensory receptor subunit T1R3 (Q37440602)

20 August 2017

Phenoxy herbicides and fibrates potently inhibit the human chemosensory receptor subunit T1R3 (English)

1 reference

20 August 2017

1 reference

1 reference

2

Robert F Margolskee

1 reference

20 August 2017

Emeline L Maillet

1

1 reference

PMCID

2783803

20 August 2017

Bedrich Mosinger

series ordinal

3

1 reference

PMCID

2783803

20 August 2017

language of work or name

English

0 references

publication date

1 November 2009

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Journal of Medicinal Chemistry

20 August 2017

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20 August 2017

52

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20 August 2017

6931-6935

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20 August 2017

21

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Sweet taste receptor expressed in pancreatic beta-cells activates the calcium and cyclic AMP signaling systems and stimulates insulin secretion

20 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2783803

The sweet taste quality is linked to a cluster of taste fibers in primates: lactisole diminishes preference and responses to sweet in S fibers (sweet best) chorda tympani fibers of M. fascicularis monkey

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2783803

Taste cells of the gut and gastrointestinal chemosensation

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2783803

Gymnema sylvestre: A Memoir.

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2783803

Enteroendocrine cells: a site of 'taste' in gastrointestinal chemosensing

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2783803

Atherosclerosis in type 2 diabetes: a role for fibrate therapy?

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2783803

Gymnema sylvestre for diabetes mellitus: a systematic review

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2783803

T1R3 and gustducin in gut sense sugars to regulate expression of Na+-glucose cotransporter 1

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2783803

Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2783803

Sweet taste receptors in rat small intestine stimulate glucose absorption through apical GLUT2

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2783803

Structure, pharmacology and therapeutic prospects of family C G-protein coupled receptors

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2783803

A TAS1R receptor-based explanation of sweet 'water-taste'.

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2783803

Mortality from ischemic heart disease and diabetes mellitus (type 2) in four U.S. wheat-producing states: a hypothesis-generating study

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2783803

Recent developments in constitutive receptor activity and inverse agonism, and their potential for GPCR drug discovery

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2783803

Therapeutic roles of peroxisome proliferator-activated receptor agonists

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2783803

Valine 738 and lysine 735 in the fifth transmembrane domain of rTas1r3 mediate insensitivity towards lactisole of the rat sweet taste receptor

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2783803

Lactisole interacts with the transmembrane domains of human T1R3 to inhibit sweet taste.

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2783803

Expression of the sweet receptor protein, T1R3, in the human liver and pancreas

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2783803

Different functional roles of T1R subunits in the heteromeric taste receptors

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2783803

The receptors for mammalian sweet and umami taste

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2783803

The PPARs: from orphan receptors to drug discovery

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2783803

Characteristics of antisweet substances, sweet proteins, and sweetness-inducing proteins

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2783803

CCAAT/Enhancer-binding protein beta regulates expression of human T1R3 taste receptor gene in the bile duct carcinoma cell line, HuCCT1.

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2783803

Dietary intake and the development of the metabolic syndrome: the Atherosclerosis Risk in Communities study.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2783803

Induction of phytohormones and differential gene expression in citrus flowers infected by the fungus Colletotrichum acutatum

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2783803

Evolution of the sweetness receptor in primates. II. Gustatory responses of non-human primates to nine compounds known to be sweet in man

2 September 2018

1 reference

12 December 2020

Cypha [propionic acid, 2-(4-methoxyphenol) salt] inhibits sweet taste in humans, but not in rats

1 reference

12 December 2020

Hypolipidemia and peroxisome proliferation induced by phenoxyacetic acid herbicides in rats

1 reference

12 December 2020

Selective Inhibition of Sweetness by the Sodium Salt of +/-2-(4-Methoxyphenoxy)propanoic Acid

1 reference

12 December 2020

Genomic structure of swine taste receptor family 1 member 3, TAS1R3, and its expression in tissues

1 reference

12 December 2020

Identifiers

DOI

10.1021/JM900823S

1 reference

20 August 2017

1 reference

20 August 2017

1 reference

PMCID

2783803