Dual orexin receptor antagonists show distinct effects on locomotor performance, ethanol interaction and sleep architecture relative to gamma-aminobutyric acid-A receptor modulators. (Q37411777)

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scientific article published on 24 December 2013

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English	Dual orexin receptor antagonists show distinct effects on locomotor performance, ethanol interaction and sleep architecture relative to gamma-aminobutyric acid-A receptor modulators.	scientific article published on 24 December 2013

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scholarly article

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4 March 2020

Dual orexin receptor antagonists show distinct effects on locomotor performance, ethanol interaction and sleep architecture relative to gamma-aminobutyric acid-A receptor modulators (English)

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Christopher Winrow

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author name string

Andres D Ramirez

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Anthony L Gotter

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Steven V Fox

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Pamela L Tannenbaum

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Lihang Yao

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Spencer J Tye

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Terrence McDonald

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Joseph Brunner

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Susan L Garson

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Duane R Reiss

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Scott D Kuduk

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Paul J Coleman

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Jason M Uslaner

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Robert Hodgson

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Susan E Browne

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John J Renger

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publication date

24 December 2013

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4 March 2020

Frontiers in Neuroscience

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4 March 2020

7

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254

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4 March 2020

The duration of sleep promoting efficacy by dual orexin receptor antagonists is dependent upon receptor occupancy threshold

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6 September 2017

Discovery and development of orexin receptor antagonists as therapeutics for insomnia

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6 September 2017

Quantitative electroencephalography within sleep/wake states differentiates GABAA modulators eszopiclone and zolpidem from dual orexin receptor antagonists in rats

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Psychotropic drugs and risk of motor vehicle accidents: a population-based case-control study

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6 September 2017

The orexin antagonist SB-649868 promotes and maintains sleep in men with primary insomnia

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International Union of Basic and Clinical Pharmacology. LXXXVI. Orexin receptor function, nomenclature and pharmacology

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Orexin receptor antagonism, a new sleep-enabling paradigm: a proof-of-concept clinical trial.

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6 September 2017

Differential effects of a dual orexin receptor antagonist (SB-649868) and zolpidem on sleep initiation and consolidation, SWS, REM sleep, and EEG power spectra in a model of situational insomnia

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Pharmacological characterization of MK-6096 - a dual orexin receptor antagonist for insomnia

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Synaptic effects induced by alcohol

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Acute optogenetic silencing of orexin/hypocretin neurons induces slow-wave sleep in mice.

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Phase I studies on the safety, tolerability, pharmacokinetics and pharmacodynamics of SB-649868, a novel dual orexin receptor antagonist

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Promotion of sleep by suvorexant-a novel dual orexin receptor antagonist

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Orexin receptors: pharmacology and therapeutic opportunities

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Orexin neuronal circuitry: role in the regulation of sleep and wakefulness

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Promotion of sleep by targeting the orexin system in rats, dogs and humans

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A double-blind, placebo-controlled investigation of the residual psychomotor and cognitive effects of zolpidem-MR in healthy elderly volunteers

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Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation

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The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene

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Neurons containing hypocretin (orexin) project to multiple neuronal systems

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Association of road-traffic accidents with benzodiazepine use.

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Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior

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26 June 2018

Effect of zolpidem on sleep and sleep EEG spectra in healthy young men.

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2 September 2018

Orexin receptor antagonism for treatment of insomnia: a randomized clinical trial of suvorexant.

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2 September 2018

Dual orexin receptor antagonism by almorexant does not potentiate impairing effects of alcohol in humans.

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Factors associated with falls during hospitalization in an older adult population

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The additive effects of alcohol and benzodiazepines on driving.

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2 September 2018

Differential effects of the dual orexin receptor antagonist almorexant and the GABA(A)-α1 receptor modulator zolpidem, alone or combined with ethanol, on motor performance in the rat.

1 reference

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Sub-chronic administration of zolpidem affects modifications to rat sleep architecture

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Benzodiazepines and the risk of falls in nursing home residents.

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.3389/FNINS.2013.00254

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Europe PubMed Central

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4 March 2020

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Europe PubMed Central

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4 March 2020

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4 March 2020

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