Cardiac resynchronization sensitizes the sarcomere to calcium by reactivating GSK-3β. (Q37410579)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24292707%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

title

Cardiac resynchronization sensitizes the sarcomere to calcium by reactivating GSK-3β (English)

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2 March 2020

1

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2 March 2020

author name string

Ronald J Holewinski

2

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2 March 2020

Viola Kooij

3

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2 March 2020

Giulio Agnetti

4

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2 March 2020

Richard S Tunin

5

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2 March 2020

Namthip Witayavanitkul

6

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2 March 2020

Pieter P de Tombe

7

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2 March 2020

Wei Dong Gao

8

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2 March 2020

Jennifer Van Eyk

9

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2 March 2020

David A Kass

10

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2 March 2020

language of work or name

English

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publication date

1 January 2014

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Journal of Clinical Investigation

2 March 2020

published in

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2 March 2020

volume

124

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2 March 2020

page(s)

129-138

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2 March 2020

issue

1

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Signaling effectors underlying pathologic growth and remodeling of the heart

2 March 2020

cites work

1 reference

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GSK3β phosphorylates newly identified site in the proline-alanine-rich region of cardiac myosin-binding protein C and alters cross-bridge cycling kinetics in human: short communication

6 September 2017

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Multiple Reaction Monitoring to Identify Site-Specific Troponin I Phosphorylated Residues in the Failing Human Heart

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AMP-activated protein kinase phosphorylates cardiac troponin I at Ser-150 to increase myofilament calcium sensitivity and blunt PKA-dependent function.

6 September 2017

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6 September 2017

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Protein kinase A-induced myofilament desensitization to Ca(2+) as a result of phosphorylation of cardiac myosin-binding protein C

6 September 2017

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Relationship of echocardiographic dyssynchrony to long-term survival after cardiac resynchronization therapy

6 September 2017

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Why does troponin I have so many phosphorylation sites? Fact and fancy

6 September 2017

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Molecular basis of hereditary cardiomyopathy: abnormalities in calcium sensitivity, stretch response, stress response and beyond

6 September 2017

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Nexilin mutations destabilize cardiac Z-disks and lead to dilated cardiomyopathy

6 September 2017

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Left ventricular and myocardial function in mice expressing constitutively pseudophosphorylated cardiac troponin I.

6 September 2017

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Protein kinase C alpha and epsilon phosphorylation of troponin and myosin binding protein C reduce Ca2+ sensitivity in human myocardium

6 September 2017

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Mechanisms of enhanced beta-adrenergic reserve from cardiac resynchronization therapy

6 September 2017

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Electrophysiological consequences of dyssynchronous heart failure and its restoration by resynchronization therapy

6 September 2017

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6 September 2017

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HDAC4 and PCAF bind to cardiac sarcomeres and play a role in regulating myofilament contractile activity

6 September 2017

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Chronic cardiac resynchronization therapy and reverse ventricular remodeling in a model of nonischemic cardiomyopathy

6 September 2017

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Significance of QRS complex duration in patients with heart failure

6 September 2017

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Functional effects of rho-kinase-dependent phosphorylation of specific sites on cardiac troponin

6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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Phosphorylation or glutamic acid substitution at protein kinase C sites on cardiac troponin I differentially depress myofilament tension and shortening velocity

6 September 2017

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Actin capping protein: an essential element in protein kinase signaling to the myofilaments

6 September 2017

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Focal adhesion kinase and p130Cas mediate both sarcomeric organization and activation of genes associated with cardiac myocyte hypertrophy

6 September 2017

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Transgenic mouse model of stunned myocardium

6 September 2017

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Molecular characterization of abLIM, a novel actin-binding and double zinc finger protein

6 September 2017

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Myofibrillar calcium sensitivity of isometric tension is increased in human dilated cardiomyopathies: role of altered beta-adrenergically mediated protein phosphorylation

6 September 2017

1 reference

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Improved left ventricular mechanics from acute VDD pacing in patients with dilated cardiomyopathy and ventricular conduction delay

6 September 2017

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Subcellular structures and function of myocytes impaired during heart failure are restored by cardiac resynchronization therapy.

28 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3871225

Heart failure-associated changes in RNA splicing of sarcomere genes

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3871225

Cardiac resynchronization therapy corrects dyssynchrony-induced regional gene expression changes on a genomic level.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3871225

p21-activated kinase increases the calcium sensitivity of rat triton-skinned cardiac muscle fiber bundles via a mechanism potentially involving novel phosphorylation of troponin I.

26 June 2018

1 reference

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Reversal of global apoptosis and regional stress kinase activation by cardiac resynchronization.

26 June 2018

1 reference

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Update on inotropic therapy in the management of acute heart failure

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3871225

Intraventricular dyssynchrony predicts mortality and morbidity after cardiac resynchronization therapy: a study using cardiovascular magnetic resonance tissue synchronization imaging.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3871225

Pacing-induced dys-synchrony preconditions rabbit myocardium against ischemia/reperfusion injury.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3871225

Mechanical dyssynchrony assessed by tissue Doppler imaging is a powerful predictor of mortality in congestive heart failure with normal QRS duration.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3871225

Effects of biventricular pacing on interstitial remodelling, tumor necrosis factor-alpha expression, and apoptotic death in failing human myocardium.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3871225

cTnT1, a cardiac troponin T isoform, decreases myofilament tension and affects the left ventricular pressure waveform

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3871225

Protein kinase C and A sites on troponin I regulate myofilament Ca2+ sensitivity and ATPase activity in the mouse myocardium

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3871225

Effect of cardiac resynchronization on myocardial efficiency and regional oxidative metabolism.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3871225

Diminished contractile response to increased heart rate in intact human left ventricular hypertrophy. Systolic versus diastolic determinants

2 September 2018

1 reference

12 December 2020

Early and late effects of cardiac resynchronization therapy on force-frequency relation and contractility regulating gene expression in heart failure patients

1 reference

12 December 2020

Augmented protein kinase C-alpha-induced myofilament protein phosphorylation contributes to myofilament dysfunction in experimental congestive heart failure

1 reference

12 December 2020

Left ventricular or biventricular pacing improves cardiac function at diminished energy cost in patients with dilated cardiomyopathy and left bundle-branch block

1 reference

12 December 2020

Decreased myocyte tension development and calcium responsiveness in rat right ventricular pressure overload

1 reference

12 December 2020

[Contractile properties, transversal stiffness and cytoskeletal protein content in Mongolian gerbils soleus fibers under long-term hindlimb suspension]

1 reference

12 December 2020

PKC-betaII sensitizes cardiac myofilaments to Ca2+ by phosphorylating troponin I on threonine-144

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI69253

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24292707%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24292707%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24292707%20AND%20SRC:MED&resulttype=core&format=json