Antidepressant-like properties of novel HDAC6-selective inhibitors with improved brain bioavailability (Q37409603)

20 August 2017

Antidepressant-like properties of novel HDAC6-selective inhibitors with improved brain bioavailability (English)

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20 August 2017

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6

Ralph Mazitschek

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Olivier Berton

9

object named as

Olivier Berton

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20 August 2017

Jeanine Jochems

1

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20 August 2017

Janette Boulden

2

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20 August 2017

Bridgin G Lee

3

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20 August 2017

Julie A Blendy

4

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20 August 2017

Matthew Jarpe

5

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20 August 2017

Ralph Mazitschek

6

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20 August 2017

John H Van Duzer

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20 August 2017

Simon Jones

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20 August 2017

language of work or name

English

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publication date

19 August 2013

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20 August 2017

Neuropsychopharmacology

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20 August 2017

39

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20 August 2017

389-400

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20 August 2017

2

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describes a project that uses

20 August 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3870780/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

exact match

https://scigraph.springernature.com/pub.10.1038/npp.2013.207

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cites work

Tubastatin, a selective histone deacetylase 6 inhibitor shows anti-inflammatory and anti-rheumatic effects

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HDAC6 mutations rescue human tau-induced microtubule defects in Drosophila.

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Class I HDAC inhibition blocks cocaine-induced plasticity by targeted changes in histone methylation

6 September 2017

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Next generation antidepressants

6 September 2017

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Epigenetic regulation of RAC1 induces synaptic remodeling in stress disorders and depression

6 September 2017

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L-acetylcarnitine causes rapid antidepressant effects through the epigenetic induction of mGlu2 receptors.

6 September 2017

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Reducing HDAC6 ameliorates cognitive deficits in a mouse model for Alzheimer's disease

6 September 2017

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Mercaptoacetamide-based class II HDAC inhibitor lowers Aβ levels and improves learning and memory in a mouse model of Alzheimer's disease

6 September 2017

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HDAC6 inhibitor blocks amyloid beta-induced impairment of mitochondrial transport in hippocampal neurons

6 September 2017

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Histone deacetylases 6 and 9 and sirtuin-1 control Foxp3+ regulatory T cell function through shared and isoform-specific mechanisms.

6 September 2017

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HDAC6 regulates glucocorticoid receptor signaling in serotonin pathways with critical impact on stress resilience

6 September 2017

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HDAC6 at the Intersection of Neuroprotection and Neurodegeneration.

6 September 2017

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Histone deacetylase 6 gates the synaptic action of acute stress in prefrontal cortex

6 September 2017

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Loss of deacetylation activity of Hdac6 affects emotional behavior in mice

6 September 2017

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Preclinical activity, pharmacodynamic, and pharmacokinetic properties of a selective HDAC6 inhibitor, ACY-1215, in combination with bortezomib in multiple myeloma

6 September 2017

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A standardized protocol for repeated social defeat stress in mice.

6 September 2017

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Animal models of obsessive-compulsive disorder: exploring pharmacology and neural substrates

6 September 2017

1 reference

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Histone deacetylase 6 and heat shock protein 90 control the functions of Foxp3(+) T-regulatory cells

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870780

Hippocampal-dependent antidepressant-like activity of histone deacetylase inhibition

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870780

Rational design and simple chemistry yield a superior, neuroprotective HDAC6 inhibitor, tubastatin A

6 September 2017

1 reference

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HDAC6 regulates mitochondrial transport in hippocampal neurons

6 September 2017

1 reference

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Inside HDAC with HDAC inhibitors

6 September 2017

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Chemical phylogenetics of histone deacetylases

6 September 2017

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HDAC6 is a target for protection and regeneration following injury in the nervous system

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870780

Antidepressant actions of histone deacetylase inhibitors

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870780

Lysine acetylation targets protein complexes and co-regulates major cellular functions

6 September 2017

1 reference

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HDAC2 negatively regulates memory formation and synaptic plasticity.

6 September 2017

1 reference

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Effects of the histone deacetylase inhibitor sodium butyrate in models of depression and anxiety.

6 September 2017

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The many roles of histone deacetylases in development and physiology: implications for disease and therapy

6 September 2017

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Histone deacetylase 6 interacts with the microtubule-associated protein tau

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870780

HDAC6 is required for epidermal growth factor-induced beta-catenin nuclear localization

6 September 2017

1 reference

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Mice lacking histone deacetylase 6 have hyperacetylated tubulin but are viable and develop normally

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870780

HDAC6 modulates cell motility by altering the acetylation level of cortactin

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870780

Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870780

HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor

6 September 2017

1 reference

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The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870780

Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870780

HDAC-6 interacts with and deacetylates tubulin and microtubules in vivo

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870780

HDAC6 is a microtubule-associated deacetylase

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870780

Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870780

The tricyclic antidepressant amitriptyline inhibits D-cyclin transactivation and induces myeloma cell apoptosis by inhibiting histone deacetylases: in vitro and in silico evidence

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870780

Histone deacetylase 6 inhibition compensates for the transport deficit in Huntington's disease by increasing tubulin acetylation

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870780

Distinct regulatory pathways control neurofilament expression and neurotransmitter synthesis in immortalized serotonergic neurons

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870780

Active maintenance of mHDA2/mHDAC6 histone-deacetylase in the cytoplasm

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870780

The use of a plus-maze to measure anxiety in the mouse

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870780

Major tranquillizers can be distinguished from minor tranquillizers on the basis of effects on marble burying and swim-induced grooming in mice

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870780

Altered gene expression of histone deacetylases in mood disorder patients.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870780

MS-275, a novel histone deacetylase inhibitor with selectivity against HDAC1, induces degradation of FLT3 via inhibition of chaperone function of heat shock protein 90 in AML cells

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870780

Foxa2 integrates the transcriptional response of the hepatocyte to fasting.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870780

Validation of a simple, ethologically relevant paradigm for assessing anxiety in mice

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870780

Induction of hyperlocomotion in mice exposed to a novel environment by inhibition of serotonin reuptake. A pharmacological characterization of diverse classes of antidepressant agents

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870780

Sensitivity to the effects of pharmacologically selective antidepressants in different strains of mice

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3870780

HDAC6 inhibitors reverse axonal loss in a mouse model of mutant HSPB1–induced Charcot-Marie-Tooth disease

2 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNPP.2013.207

The effect of curcumin on sepsis-induced acute lung injury in a rat model through the inhibition of the TGF-β1/SMAD3 pathway

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNPP.2013.207

21 January 2018

Identifiers

DOI

10.1038/NPP.2013.207

1 reference

20 August 2017

1 reference

20 August 2017

1 reference