Structure-kinetic relationship analysis of the therapeutic complement inhibitor compstatin (Q37384384)

20 August 2017

Structure-kinetic relationship analysis of the therapeutic complement inhibitor compstatin (English)

1 reference

20 August 2017

Daniel Ricklin

2

0 references

Yiannis N. Kaznessis

object named as

Yiannis N Kaznessis

5

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John D. Lambris

object named as

John D Lambris

6

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author name string

Paola Magotti

1

1 reference

PMCID

2760637

20 August 2017

Hongchang Qu

3

1 reference

PMCID

2760637

20 August 2017

You-Qiang Wu

4

1 reference

20 August 2017

1 November 2009

1 reference

Journal of Molecular Recognition

20 August 2017

1 reference

20 August 2017

22

1 reference

20 August 2017

495-505

1 reference

20 August 2017

6

1 reference

Path-integral method for predicting relative binding affinities of protein-ligand complexes.

20 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2760637

Compstatin: a complement inhibitor on its way to clinical application

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2760637

Do enthalpy and entropy distinguish first in class from best in class?

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2760637

Complement-targeted therapeutics

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2760637

Exploring the complement interaction network using surface plasmon resonance.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2760637

Structure of compstatin in complex with complement component C3c reveals a new mechanism of complement inhibition

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2760637

The role of complement in inflammatory diseases from behind the scenes into the spotlight

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2760637

A simple, yet highly accurate, QSAR model captures the complement inhibitory activity of compstatin

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2760637

A new strategy for improved secondary screening and lead optimization using high-resolution SPR characterization of compound-target interactions

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2760637

The complement system as a therapeutic target in autoimmunity

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2760637

Relationships between structure and interaction kinetics for HIV-1 protease inhibitors

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2760637

Optical biosensors in drug discovery

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2760637

Kinetic analysis of estrogen receptor/ligand interactions

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2760637

Beta-amino acids: versatile peptidomimetics

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2760637

Direct measurement of protein binding energetics by isothermal titration calorimetry

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2760637

Complement inhibitors: a resurgent concept in anti-inflammatory therapeutics

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2760637

Solution structure of Compstatin, a potent complement inhibitor

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2760637

Inhibition of human complement by a C3-binding peptide isolated from a phage-displayed random peptide library.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2760637

LIGPLOT: a program to generate schematic diagrams of protein-ligand interactions

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2760637

HF cleavage and deprotection procedures for peptides synthesized using a Boc/Bzl strategy

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2760637

Solid-phase peptide synthesis

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2760637

Development of a new pharmacophore model that discriminates active compstatin analogs

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2760637

The structural basis of compstatin activity examined by structure-function-based design of peptide analogs and NMR.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2760637

Binding kinetics, structure-activity relationship, and biotransformation of the complement inhibitor compstatin

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2760637

Comparative analysis of 10 small molecules binding to carbonic anhydrase II by different investigators using Biacore technology.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2760637

Design and NMR characterization of active analogues of compstatin containing non-natural amino acids

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2760637

Thermodynamic studies on the interaction of the third complement component and its inhibitor, compstatin

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2760637

Kinetic analysis of the interactions of complement receptor 2 (CR2, CD21) with its ligands C3d, iC3b, and the EBV glycoprotein gp350/220.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2760637

Improving biosensor analysis

2 September 2018

1 reference

12 December 2020

Inhibition of Heparin/Protamine Complex-Induced Complement Activation by Compstatin in Baboons

1 reference

12 December 2020

Inhibitor of complement, Compstatin, prevents polymer-mediated Mac-1 up-regulation of human neutrophils independent of biomaterial type tested

1 reference

12 December 2020

Compstatin inhibits complement and cellular activation in whole blood in two models of extracorporeal circulation

1 reference

12 December 2020

Prolongation of ex vivo–perfused pig xenograft survival by the complement inhibitor compstatin

1 reference

12 December 2020

Compstatin, a peptide inhibitor of C3, prolongs survival of ex vivo perfused pig xenografts

1 reference

12 December 2020

Hydrophobic Effect and Hydrogen Bonds Account for the Improved Activity of a Complement Inhibitor, Compstatin

1 reference

12 December 2020

Age-related macular degeneration

1 reference

12 December 2020

Identifiers

DOI

10.1002/JMR.972

1 reference

20 August 2017

1 reference

20 August 2017

1 reference

PMCID

2760637