Acyltransferases for secreted signalling proteins (Review). (Q37377697)

20 August 2017

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title

Acyltransferases for secreted signalling proteins (Review). (English)

1 reference

20 August 2017

Shu-Chun Chang

1

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PubMed ID

19169935

20 August 2017

Anthony I Magee

series ordinal

2

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20 August 2017

30 January 2009

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Molecular Membrane Biology

20 August 2017

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20 August 2017

26

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20 August 2017

1

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20 August 2017

104-113

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Palmitoylation of the EGFR ligand Spitz by Rasp increases Spitz activity by restricting its diffusion

20 August 2017

1 reference

https://api.crossref.org/works/10.1080%2F09687680802706432

Palmitoylation of intracellular signaling proteins: regulation and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687680802706432

Trafficking and signaling by fatty-acylated and prenylated proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687680802706432

The Drosophila ortholog of the human Wnt inhibitor factor Shifted controls the diffusion of lipid-modified Hedgehog

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687680802706432

A superfamily of membrane-bound O-acyltransferases with implications for wnt signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687680802706432

Acyl-CoA:lysophospholipid acyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687680802706432

Mammalian Gup1, a homolog of Saccharomyces cerevisiae glycerol uptake/transporter 1, acts as a negative regulator for N-terminal palmitoylation of Sonic hedgehog

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687680802706432

GUP1 of Saccharomyces cerevisiae encodes an O-acyltransferase involved in remodeling of the GPI anchor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687680802706432

Hedgehog signal transduction: recent findings

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687680802706432

Sonic hedgehog in CNS development: one signal, multiple outputs

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687680802706432

Teratogen-mediated inhibition of target tissue response to Shh signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687680802706432

A mammalian patched homolog is expressed in target tissues of sonic hedgehog and maps to a region associated with developmental abnormalities

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687680802706432

Hhat is a palmitoylacyltransferase with specificity for N-palmitoylation of Sonic Hedgehog

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687680802706432

Crystal structure of a Hedgehog autoprocessing domain: homology between Hedgehog and self-splicing proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687680802706432

Novel lipid modifications of secreted protein signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687680802706432

Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified hedgehog from signaling cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687680802706432

Mouse dispatched mutants fail to distribute hedgehog proteins and are defective in hedgehog signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687680802706432

Multiple roles for lipids in the Hedgehog signalling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687680802706432

Cholesterol modification of sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687680802706432

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687680802706432

The role of cholesterol in Shh signaling and teratogen-induced holoprosencephaly

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687680802706432

Hedgehog signaling: a tale of two lipids

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687680802706432

Association of sterol- and glycosylphosphatidylinositol-linked proteins with Drosophila raft lipid microdomains.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687680802706432

Identification of a palmitic acid-modified form of human Sonic hedgehog

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687680802706432

Skinny hedgehog, an acyltransferase required for palmitoylation and activity of the hedgehog signal

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687680802706432

Acyl-CoA-binding protein (ACBP) localizes to the endoplasmic reticulum and Golgi in a ligand-dependent manner in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687680802706432

Hedgehog signalling in cancer formation and maintenance

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687680802706432

Unique self-palmitoylation activity of the transport protein particle component Bet3: a mechanism required for protein stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687680802706432

Cholesterol modification is necessary for controlled planar long-range activity of Hedgehog in Drosophila epithelia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687680802706432

Hedgehog lipid modifications are required for Hedgehog stabilization in the extracellular matrix

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687680802706432

Lumenal transmission of decapentaplegic in Drosophila imaginal discs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687680802706432

Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687680802706432

Heparan sulfate proteoglycan as a plasma membrane carrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687680802706432

Order out of chaos: assembly of ligand binding sites in heparan sulfate

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687680802706432

Heparan sulfate proteoglycan modulation of developmental signaling in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687680802706432

The cell-surface proteoglycan Dally regulates Wingless signalling in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687680802706432

Developmental roles of heparan sulfate proteoglycans in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687680802706432

Heparan sulfate proteoglycans exert positive and negative effects in Shh activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687680802706432

Cholesterol modification of hedgehog is required for trafficking and movement, revealing an asymmetric cellular response to hedgehog

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687680802706432

Temporal modulation of the Hedgehog morphogen gradient by a patched-dependent targeting to lysosomal compartment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687680802706432

The glypican Dally-like is required for Hedgehog signalling in the embryonic epidermis of Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687680802706432

Wingless, hedgehog and heparan sulfate proteoglycans

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687680802706432

A freely diffusible form of Sonic hedgehog mediates long-range signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687680802706432

Perlecan signaling: helping hedgehog stimulate prostate cancer growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687680802706432

Heparan sulfate proteoglycans at a glance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687680802706432

Perlecan, a candidate gene for the CAPB locus, regulates prostate cancer cell growth via the Sonic Hedgehog pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687680802706432

Shifted, the Drosophila ortholog of Wnt inhibitory factor-1, controls the distribution and movement of Hedgehog

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687680802706432

Mechanisms of Hedgehog gradient formation and interpretation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687680802706432

Syndecans: proteoglycan regulators of cell-surface microdomains?

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687680802706432

Nanoscale organization of hedgehog is essential for long-range signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687680802706432

In vivo role of lipid adducts on Wingless

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687680802706432

Wnt proteins are lipid-modified and can act as stem cell growth factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687680802706432

Monounsaturated fatty acid modification of Wnt protein: its role in Wnt secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687680802706432

Lipid-independent secretion of a Drosophila Wnt protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687680802706432

The segment polarity gene porcupine encodes a putative multitransmembrane protein involved in Wingless processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687680802706432

The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687680802706432

Porcupine-mediated lipid-modification regulates the activity and distribution of Wnt proteins in the chick neural tube

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687680802706432

Wnt lipid modifications: not as saturated as we thought.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687680802706432

Suppression of PPN/MG61 attenuates Wnt/beta-catenin signaling pathway and induces apoptosis in human lung cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687680802706432

Post-translational palmitoylation and glycosylation of Wnt-5a are necessary for its signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687680802706432

Regulation of Wnt protein secretion and its role in gradient formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687680802706432

Drosophila wnt-1 undergoes a hydrophobic modification and is targeted to lipid rafts, a process that requires porcupine

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687680802706432

Reggie-1/flotillin-2 promotes secretion of the long-range signalling forms of Wingless and Hedgehog in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687680802706432

Ghrelin octanoylation mediated by an orphan lipid transferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687680802706432

Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687680802706432

One ancestor, several peptides post-translational modifications of preproghrelin generate several peptides with antithetical effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687680802706432

Inhibition of ghrelin O-acyltransferase (GOAT) by octanoylated pentapeptides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687680802706432

Gastric O-acyl transferase activates hunger signal to the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687680802706432

Ingested medium-chain fatty acids are directly utilized for the acyl modification of ghrelin

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687680802706432

10.1080/09687680802706432

21 January 2018

Identifiers

DOI

1 reference

20 August 2017

1 reference

PubMed ID

19169935