Immunotherapy for the prevention and treatment of type 1 diabetes: human trials and a look into the future (Q37364899)

19 August 2017

0 references

Immunotherapy for the prevention and treatment of type 1 diabetes: human trials and a look into the future (English)

1 reference

19 August 2017

0 references

1 reference

1

Marian Rewers

1 reference

19 August 2017

Peter Gottlieb

2

1 reference

PMCID

2752911

19 August 2017

language of work or name

English

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publication date

1 October 2009

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19 August 2017

1 reference

19 August 2017

32

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19 August 2017

10

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19 August 2017

1769-1782

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Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported

19 August 2017

start time

28 August 2021

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

No effect of the altered peptide ligand NBI-6024 on beta-cell residual function and insulin needs in new-onset type 1 diabetes

1 reference

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Effect of ingested interferon-alpha on beta-cell function in children with new-onset type 1 diabetes

6 September 2017

1 reference

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Etanercept treatment in children with new-onset type 1 diabetes: pilot randomized, placebo-controlled, double-blind study

6 September 2017

1 reference

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C-peptide levels and insulin independence following autologous nonmyeloablative hematopoietic stem cell transplantation in newly diagnosed type 1 diabetes mellitus

6 September 2017

1 reference

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Do non-HLA genes influence development of persistent islet autoimmunity and type 1 diabetes in children with high-risk HLA-DR,DQ genotypes?

6 September 2017

1 reference

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Autologous hematopoietic stem cell transplantation for type 1 diabetes

6 September 2017

1 reference

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The Environmental Determinants of Diabetes in the Young (TEDDY) Study

6 September 2017

1 reference

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Beta-cell mass and type 1 diabetes: going, going, gone?

6 September 2017

1 reference

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GAD treatment and insulin secretion in recent-onset type 1 diabetes

6 September 2017

1 reference

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Vitamin D signaling in immune-mediated disorders: Evolving insights and therapeutic opportunities

6 September 2017

1 reference

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Effects of beta-cell rest on beta-cell function: a review of clinical and preclinical data

6 September 2017

1 reference

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Polyclonal anti-T-cell therapy for type 1 diabetes mellitus of recent onset

6 September 2017

1 reference

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Autologous nonmyeloablative hematopoietic stem cell transplantation in newly diagnosed type 1 diabetes mellitus

6 September 2017

1 reference

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Translational mini-review series on type 1 diabetes: Immune-based therapeutic approaches for type 1 diabetes

6 September 2017

1 reference

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Extreme genetic risk for type 1A diabetes

6 September 2017

1 reference

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Natural history of beta-cell function in type 1 diabetes

6 September 2017

1 reference

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A comprehensive review of interventions in the NOD mouse and implications for translation

6 September 2017

1 reference

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Insulin needs after CD3-antibody therapy in new-onset type 1 diabetes

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2752911

A single course of anti-CD3 monoclonal antibody hOKT3gamma1(Ala-Ala) results in improvement in C-peptide responses and clinical parameters for at least 2 years after onset of type 1 diabetes

6 September 2017

1 reference

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Timing of Initial Cereal Exposure in Infancy and Risk of Islet Autoimmunity

6 September 2017

1 reference

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Anti-thymocyte globulin and prednisone immunotherapy of recent onset type 1 diabetes mellitus.

6 September 2017

1 reference

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Islet cell survival determined by morphology. An immunocytochemical study of the islets of Langerhans in juvenile diabetes mellitus

6 September 2017

1 reference

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Proinsulin peptide immunotherapy in type 1 diabetes: report of a first-in-man Phase I safety study.

6 September 2017

1 reference

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Time trends in the incidence of type 1 diabetes in Finnish children: a cohort study

14 September 2017

1 reference

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Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus

14 September 2017

1 reference

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Immunotherapy for the prevention and treatment of type 1 diabetes: optimizing the path from bench to bedside

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2752911

Taking a daily vitamin to prevent type 1 diabetes?

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2752911

Heat-shock protein peptide DiaPep277 treatment in children with newly diagnosed type 1 diabetes: a randomised, double-blind phase II study

26 June 2018

1 reference

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Beta-cell function in new-onset type 1 diabetes and immunomodulation with a heat-shock protein peptide (DiaPep277): a randomised, double-blind, phase II trial

26 June 2018

1 reference

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Prediction of IDDM in the general population: strategies based on combinations of autoantibody markers

26 June 2018

1 reference

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Cyclosporin increases the rate and length of remissions in insulin-dependent diabetes of recent onset. Results of a multicentre double-blind trial.

26 June 2018

1 reference

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Natural Course of Remission in IDDM During 1st yr After Diagnosis

26 June 2018

1 reference

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GAD65 vaccination: 5 years of follow-up in a randomised dose-escalating study in adult-onset autoimmune diabetes.

26 June 2018

1 reference

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Omega-3 polyunsaturated fatty acid intake and islet autoimmunity in children at increased risk for type 1 diabetes

2 September 2018

1 reference

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The Environmental Determinants of Diabetes in the Young (TEDDY) study: study design

2 September 2018

1 reference

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Study design of the Trial to Reduce IDDM in the Genetically at Risk (TRIGR).

2 September 2018

1 reference

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Increasing incidence of type 1 diabetes in 0- to 17-year-old Colorado youth

2 September 2018

1 reference

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Increasing the accuracy of oral glucose tolerance testing and extending its application to individuals with normal glucose tolerance for the prediction of type 1 diabetes: the Diabetes Prevention Trial-Type 1.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2752911

Patterns of metabolic progression to type 1 diabetes in the Diabetes Prevention Trial-Type 1.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2752911

Sustained beta cell apoptosis in patients with long-standing type 1 diabetes: indirect evidence for islet regeneration?

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2752911

Effects of oral insulin in relatives of patients with type 1 diabetes: The Diabetes Prevention Trial--Type 1.

2 September 2018

1 reference

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ADA Outstanding Scientific Achievement Lecture 2004. Thirty years of investigating the autoimmune basis for type 1 diabetes: why can't we prevent or reverse this disease?

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2752911

Maternal efforts to prevent type 1 diabetes in at-risk children

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2752911

Insulin resistance is a risk factor for progression to type 1 diabetes

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2752911

BABYDIET, a feasibility study to prevent the appearance of islet autoantibodies in relatives of patients with Type 1 diabetes by delaying exposure to gluten.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2752911

Clinical characteristics of children diagnosed with type 1 diabetes through intensive screening and follow-up.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2752911

Complete long-term recovery of beta-cell function in autoimmune type 1 diabetes after insulin treatment.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2752911

European Nicotinamide Diabetes Intervention Trial (ENDIT): a randomised controlled trial of intervention before the onset of type 1 diabetes

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2752911

C-peptide is the appropriate outcome measure for type 1 diabetes clinical trials to preserve beta-cell function: report of an ADA workshop, 21-22 October 2001.

2 September 2018

1 reference

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Guidelines for Intervention Trials in Subjects With Newly Diagnosed Type 1 Diabetes

2 September 2018

1 reference

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Decreasing incidence of severe diabetic microangiopathy in type 1 diabetes.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2752911

Beta-cell function and the development of diabetes-related complications in the diabetes control and complications trial

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2752911

Effects of insulin in relatives of patients with type 1 diabetes mellitus

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2752911

Mortality trends in type 1 diabetes. The Allegheny County (Pennsylvania) Registry 1965-1999.

2 September 2018

1 reference

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Incidence of childhood type 1 diabetes worldwide. Diabetes Mondiale (DiaMond) Project Group

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2752911

Feasibility of genetic and immunological prediction of type I diabetes in a population-based birth cohort

2 September 2018

1 reference

12 December 2020

Factors predicting course of beta-cell function in IDDM

1 reference

12 December 2020

Immunomodulation in type 1 diabetes by NBI-6024, an altered peptide ligand of the insulin B epitope

1 reference

12 December 2020

The 30-year natural history of type 1 diabetes complications: the Pittsburgh Epidemiology of Diabetes Complications Study experience

1 reference

12 December 2020

Type 1 diabetes risk assessment: improvement by follow-up measurements in young islet autoantibody-positive relatives

1 reference

12 December 2020

Normal but increasing hemoglobin A1c levels predict progression from islet autoimmunity to overt type 1 diabetes: Diabetes Autoimmunity Study in the Young (DAISY)

1 reference

12 December 2020

Effect of heat shock protein peptide DiaPep277 on beta-cell function in paediatric and adult patients with recent-onset diabetes mellitus type 1: two prospective, randomized, double-blind phase II trials

1 reference

12 December 2020

Feasibility of a type 1 diabetes primary prevention trial using 2000 IU vitamin D3 in infants from the general population with increased HLA-associated risk

1 reference

12 December 2020

GAD65 autoantibody epitopes in adult patients with latent autoimmune diabetes following GAD65 vaccination

1 reference

12 December 2020

Role of insulin resistance in predicting progression to type 1 diabetes

1 reference

12 December 2020

Nasal insulin to prevent type 1 diabetes in children with HLA genotypes and autoantibodies conferring increased risk of disease: a double-blind, randomised controlled trial

1 reference

12 December 2020

Limited duration of remission of insulin dependency in children with recent overt type I diabetes treated with low-dose cyclosporin

1 reference

12 December 2020

Secular trends in incidence of childhood IDDM in 10 countries. Diabetes Epidemiology Research International Group

1 reference

12 December 2020

Cyclosporin-induced remission of IDDM after early intervention. Association of 1 yr of cyclosporin treatment with enhanced insulin secretion. The Canadian-European Randomized Control Trial Group

1 reference

12 December 2020

Evidence of an accelerated B-cell destruction in HLA-Dw3/Dw4 heterozygous children with type 1 (insulin-dependent) diabetes

1 reference

12 December 2020

Vitamin-D poisoning: survey of causes in 21 patients with hypercalcaemia

1 reference

12 December 2020

Identifiers

DOI

10.2337/DC09-0374

1 reference

19 August 2017

1 reference

19 August 2017

1 reference

PMCID

2752911