Spectroscopic evidence for an engineered, catalytically active Trp radical that creates the unique reactivity of lignin peroxidase. (Q37364178)

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9 February 2020

title

Spectroscopic evidence for an engineered, catalytically active Trp radical that creates the unique reactivity of lignin peroxidase (English)

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9 February 2020

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3

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9 February 2020

author name string

Andrew T Smith

series ordinal

1

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9 February 2020

Wendy A Doyle

series ordinal

2

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9 February 2020

Anabella Ivancich

series ordinal

4

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9 February 2020

language of work or name

English

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publication date

14 September 2009

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Proceedings of the National Academy of Sciences of the United States of America

9 February 2020

published in

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9 February 2020

volume

106

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9 February 2020

issue

38

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9 February 2020

page(s)

16084-16089

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Protein Radicals in Fungal Versatile Peroxidase: CATALYTIC TRYPTOPHAN RADICAL IN BOTH COMPOUND I AND COMPOUND II AND STUDIES ON W164Y, W164H, AND W164S VARIANTS

9 February 2020

cites work

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Replacement of an Electron Transfer Pathway in Cytochrome c Peroxidase with a Surrogate Peptide † , ‡

6 September 2017

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Tryptophan-accelerated electron flow through proteins

6 September 2017

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Versatile peroxidase oxidation of high redox potential aromatic compounds: site-directed mutagenesis, spectroscopic and crystallographic investigation of three long-range electron transfer pathways.

6 September 2017

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Spectroscopy and Reactivity of a Photogenerated Tryptophan Radical in a Structurally Defined Protein Environment

6 September 2017

1 reference

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Crystal structures of pristine and oxidatively processed lignin peroxidase expressed in Escherichia coli and of the W171F variant that eliminates the redox active tryptophan 171. Implications for the reaction mechanism

6 September 2017

1 reference

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Substrate specificity of lignin peroxidase and a S168W variant of manganese peroxidase

6 September 2017

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The crystal structure of lignin peroxidase at 1.70 A resolution reveals a hydroxy group on the cbeta of tryptophan 171: a novel radical site formed during the redox cycle

6 September 2017

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Rational design of a functional metalloenzyme: introduction of a site for manganese binding and oxidation into a heme peroxidase

6 September 2017

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Two substrate interaction sites in lignin peroxidase revealed by site-directed mutagenesis

6 September 2017

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Zero-field splitting of Fe3+ in horseradish peroxidase and of Fe4+ in horseradish peroxidase compound I from electron spin relaxation data

6 September 2017

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Identification by ENDOR of Trp191 as the free-radical site in cytochrome c peroxidase compound ES.

6 September 2017

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Crystal structure of a complex between electron transfer partners, cytochrome c peroxidase and cytochrome c

6 September 2017

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Horseradish peroxidase compound I: evidence for spin coupling between the heme iron and a ‘free’ radical

6 September 2017

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Influence of aromatic substitution patterns on azo dye degradability by Streptomyces spp. and Phanerochaete chrysosporium

14 September 2017

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Distinct role of specific tryptophans in facilitating electron transfer or as [Fe(IV)=O Trp(*)] intermediates in the peroxidase reaction of Bulkholderia pseudomallei catalase-peroxidase: a multifrequency EPR spectroscopy investigation.

26 June 2018

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Intramolecular electron transfer versus substrate oxidation in lactoperoxidase: investigation of radical intermediates by stopped-flow absorption spectrophotometry and (9-285 GHz) electron paramagnetic resonance spectroscopy

2 September 2018

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Two [Fe(IV)=O Trp*] intermediates in M. tuberculosis catalase-peroxidase discriminated by multifrequency (9-285 GHz) EPR spectroscopy: reactivity toward isoniazid

2 September 2018

1 reference

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pH Rate profiles of FnY356-R2s (n = 2, 3, 4) in Escherichia coli ribonucleotide reductase: evidence that Y356 is a redox-active amino acid along the radical propagation pathway

2 September 2018

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A tryptophan neutral radical in the oxidized state of versatile peroxidase from Pleurotus eryngii: a combined multifrequency EPR and density functional theory study.

2 September 2018

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The g-values and hyperfine coupling of amino acid radicals in proteins: comparison of experimental measurements with ab initio calculations

2 September 2018

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Tryptophan-based radical in the catalytic mechanism of versatile peroxidase from Bjerkandera adusta

2 September 2018

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Substrate electric dipole moment exerts a pH-dependent effect on electron transfer in Escherichia coli photolyase.

2 September 2018

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Comparative electron paramagnetic resonance study of radical intermediates in turnip peroxidase isozymes

2 September 2018

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Redesign of cytochrome c peroxidase into a manganese peroxidase: role of tryptophans in peroxidase activity

2 September 2018

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12 December 2020

Evidence from spin-trapping for a transient radical on tryptophan residue 171 of lignin peroxidase

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12 December 2020

EPR detection and characterization of lignin peroxidase porphyrin pi-cation radical

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12 December 2020

Protein Radicals in Enzyme Catalysis

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12 December 2020

Construction and characterization of a manganese-binding site in cytochrome c peroxidase: towards a novel manganese peroxidase

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12 December 2020

Superoxide produced in the heme pocket of the beta-chain of hemoglobin reacts with the beta-93 cysteine to produce a thiyl radical

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12 December 2020

The iron-oxygen reconstitution reaction in protein R2-Tyr-177 mutants of mouse ribonucleotide reductase. Epr and electron nuclear double resonance studies on a new transient tryptophan radical

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12 December 2020

Identifiers

DOI

10.1073/PNAS.0904535106

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19805263%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

0 references

1 reference

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9 February 2020

PubMed publication ID

19805263

1 reference