Mitochondrial lipid oxidation is impaired in cultured myotubes from obese humans (Q37359316)

19 August 2017

Mitochondrial lipid oxidation is impaired in cultured myotubes from obese humans (English)

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19 August 2017

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K E Boyle

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19 August 2017

D Zheng

2

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19 August 2017

E J Anderson

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19 August 2017

P D Neufer

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19 August 2017

J A Houmard

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19 August 2017

language of work or name

English

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publication date

25 October 2011

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International Journal of Obesity

19 August 2017

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19 August 2017

36

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19 August 2017

8

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19 August 2017

1025-1031

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https://scigraph.springernature.com/pub.10.1038/ijo.2011.201

19 August 2017

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Increased reactive oxygen species production and lower abundance of complex I subunits and carnitine palmitoyltransferase 1B protein despite normal mitochondrial respiration in insulin-resistant human skeletal muscle

6 September 2017

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Lipid partitioning, incomplete fatty acid oxidation, and insulin signal transduction in primary human muscle cells: effects of severe obesity, fatty acid incubation, and fatty acid translocase/CD36 overexpression

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Peroxisome proliferator-activated receptor-gamma coactivator-1alpha overexpression increases lipid oxidation in myocytes from extremely obese individuals

6 September 2017

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AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

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Primary cell cultures in the study of human muscle metabolism

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Patients with type 2 diabetes have normal mitochondrial function in skeletal muscle

6 September 2017

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Elevated stearoyl-CoA desaturase-1 expression in skeletal muscle contributes to abnormal fatty acid partitioning in obese humans

6 September 2017

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Fatty acid-induced differential regulation of the genes encoding peroxisome proliferator-activated receptor-gamma coactivator-1alpha and -1beta in human skeletal muscle cells that have been differentiated in vitro

6 September 2017

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Dynamic changes in fat oxidation in human primary myocytes mirror metabolic characteristics of the donor

6 September 2017

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6 September 2017

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Human skeletal muscle PDH kinase activity and isoform expression during a 3-day high-fat/low-carbohydrate diet

6 September 2017

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Intramuscular lipid content is increased in obesity and decreased by weight loss

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6 September 2017

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Pyruvate suppresses PGC1alpha expression and substrate utilization despite increased respiratory chain content in C2C12 myotubes

6 September 2017

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Reduced lipid oxidation in myotubes established from obese and type 2 diabetic subjects

14 September 2017

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Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance

14 September 2017

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Abnormal metabolism flexibility in response to high palmitate concentrations in myotubes derived from obese type 2 diabetic patients

14 September 2017

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Oxidation of intramyocellular lipids is dependent on mitochondrial function and the availability of extracellular fatty acids

26 June 2018

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Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans

26 June 2018

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Fatty acid incubation of myotubes from humans with type 2 diabetes leads to enhanced release of beta-oxidation products because of impaired fatty acid oxidation: effects of tetradecylthioacetic acid and eicosapentaenoic acid

26 June 2018

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Lower intrinsic ADP-stimulated mitochondrial respiration underlies in vivo mitochondrial dysfunction in muscle of male type 2 diabetic patients

26 June 2018

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Metabolic flexibility is conserved in diabetic myotubes

26 June 2018

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The diabetic phenotype is conserved in myotubes established from diabetic subjects: evidence for primary defects in glucose transport and glycogen synthase activity

26 June 2018

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Failure to increase lipid oxidation in response to increasing dietary fat content in formerly obese women.

26 June 2018

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Nutrient balance and energy expenditure during ad libitum feeding of high-fat and high-carbohydrate diets in humans

26 June 2018

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Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation

26 June 2018

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High-fat diet, muscular lipotoxicity and insulin resistance

2 September 2018

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Intramyocellular lipid content and molecular adaptations in response to a 1-week high-fat diet

2 September 2018

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Peroxisome proliferator-activated receptor-gamma co-activator 1alpha-mediated metabolic remodeling of skeletal myocytes mimics exercise training and reverses lipid-induced mitochondrial inefficiency.

2 September 2018

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Skeletal muscle lipid metabolism with obesity

2 September 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3848508

Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity, and weight loss

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3848508

Lipid oxidation is reduced in obese human skeletal muscle

2 September 2018

1 reference

12 December 2020

A short-term, high-fat diet up-regulates lipid metabolism and gene expression in human skeletal muscle

1 reference

12 December 2020

Mitochondrial Respiration Is Decreased in Skeletal Muscle of Patients With Type 2 Diabetes

1 reference

12 December 2020

Skeletal muscle mitochondrial FAT/CD36 content and palmitate oxidation are not decreased in obese women

1 reference

12 December 2020

Identifiers

DOI

10.1038/IJO.2011.201

1 reference

19 August 2017

1 reference

19 August 2017

PubMed publication ID

22024640

1 reference