GAD65 autoimmunity-clinical studies. (Q37358994)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19111163%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

review article

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title

GAD65 autoimmunity-clinical studies (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19111163%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19111163%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

author name string

Ake Lernmark

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19111163%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

publication date

1 January 2008

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19111163%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

published in

Advances in Immunology

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19111163%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

volume

100

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19111163%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

page(s)

39-78

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19111163%20AND%20SRC:MED&resulttype=core&format=json

Co-expression of HLA DR3 and DQ8 results in the development of spontaneous insulitis and loss of tolerance to GAD65 in transgenic mice

19 January 2020

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Clinical evidence for the safety of GAD65 immunomodulation in adult-onset autoimmune diabetes

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Time-resolved immunofluorometric dual-label assay for simultaneous detection of autoantibodies to GAD65 and IA-2 in children with type 1 diabetes

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7 January 2021

Autoreactive T cell responses show proinflammatory polarization in diabetes but a regulatory phenotype in health

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7 January 2021

Response of peripheral-blood mononuclear cells to glutamate decarboxylase in insulin-dependent diabetes

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7 January 2021

Regulatory T cells under scrutiny

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7 January 2021

Expression of major histocompatibility antigens on pancreatic islet cells

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7 January 2021

Autoantibodies in newly diagnosed diabetic children immunoprecipitate human pancreatic islet cell proteins

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7 January 2021

Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase

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7 January 2021

Modulation of antigen presentation by autoreactive B cell clones specific for GAD65 from a type I diabetic patient

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7 January 2021

GAD65 autoantibody epitopes in adult patients with latent autoimmune diabetes following GAD65 vaccination

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7 January 2021

The lymphopenia (lyp) gene controls the intrathymic cytokine ratio in congenic BioBreeding rats

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7 January 2021

GAD65 and insulin B chain peptide (9-23) are not primary autoantigens in the type 1 diabetes syndrome of the BB rat

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7 January 2021

Diabetes Antibody Standardization Program: First Assay Proficiency Evaluation

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7 January 2021

Immunization of HLA class I transgenic mice identifies autoantigenic epitopes eliciting dominant responses in type 1 diabetes patients

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7 January 2021

Maturation of the humoral autoimmune response to epitopes of GAD in preclinical childhood type 1 diabetes

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7 January 2021

Separate autoantibodies to human pancreatic glucagon and somatostatin cells

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7 January 2021

Islet-cell antibodies in diabetes mellitus with autoimmune polyendocrine deficiencies

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7 January 2021

Moving towards efficient therapies in type 1 diabetes: to combine or not to combine?

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7 January 2021

Sequences homologous to glutamic acid decarboxylase cDNA are present on mouse chromosomes 2 and 10.

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7 January 2021

A sensitive non-isotopic assay for GAD65 autoantibodies

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7 January 2021

No alterations in the frequency of FOXP3+ regulatory T-cells in type 1 diabetes

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7 January 2021

Two human glutamate decarboxylases, 65-kDa GAD and 67-kDa GAD, are each encoded by a single gene

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7 January 2021

High definition profiling of autoantibodies to glutamic acid decarboxylases GAD65/GAD67 in stiff-person syndrome

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7 January 2021

Alternative splicing of GAD67 results in the synthesis of a third form of glutamic-acid decarboxylase in human islets and other non-neural tissues

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7 January 2021

IgG subclass antibodies to glutamic acid decarboxylase and risk for progression to clinical insulin-dependent diabetes

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7 January 2021

Comparative study of GAD65-specific CD4+ T cells in healthy and type 1 diabetic subjects

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7 January 2021

The good turned ugly: immunopathogenic basis for diabetogenic CD8+ T cells in NOD mice

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7 January 2021

Targeting of the 67-kDa isoform of glutamic acid decarboxylase to intracellular organelles is mediated by its interaction with the NH2-terminal region of the 65-kDa isoform of glutamic acid decarboxylase

1 reference

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7 January 2021

Cytotoxic autoantibodies to beta cells in the serum of patients with insulin-dependent diabetes mellitus

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7 January 2021

Insulin autoimmunity: prediction/precipitation/prevention type 1A diabetes

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7 January 2021

HLA Class II molecules on haplotypes associated with type 1 diabetes exhibit similar patterns of binding affinities for coxsackievirus P2C peptides.

1 reference

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7 January 2021

Identification of naturally processed T cell epitopes from glutamic acid decarboxylase presented in the context of HLA-DR alleles by T lymphocytes of recent onset IDDM patients

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7 January 2021

Radioimmunoassay detects the frequent occurrence of autoantibodies to the Mr 65,000 isoform of glutamic acid decarboxylase in Japanese insulin-dependent diabetes

1 reference

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7 January 2021

Molecular characterization of a disease associated conformational epitope on GAD65 recognised by a human monoclonal antibody b96.11.

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7 January 2021

GABA production by glutamic acid decarboxylase is regulated by a dynamic catalytic loop

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7 January 2021

COOH-Terminal Clustering of Autoantibody and T-Cell Determinants on the Structure of GAD65 Provide Insights Into the Molecular Basis of Autoreactivity

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7 January 2021

Regulating self-tolerance by deregulating gene expression

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7 January 2021

Genetic effects on age-dependent onset and islet cell autoantibody markers in type 1 diabetes

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7 January 2021

Processing and presentation of the islet autoantigen GAD by vascular endothelial cells promotes transmigration of autoreactive T-cells

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7 January 2021

A novel radioligand binding assay to determine diagnostic accuracy of isoform-specific glutamic acid decarboxylase antibodies in childhood IDDM

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7 January 2021

APC-derived cytokines and T cell polarization in autoimmune inflammation

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7 January 2021

TEDDY--The Environmental Determinants of Diabetes in the Young: an observational clinical trial

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7 January 2021

Species-Specific Autoantibodies in Type 1 Diabetes

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7 January 2021

Recognition of glutamic acid decarboxylase (GAD) by autoantibodies from different GAD antibody-positive phenotypes

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7 January 2021

Antibodies to IA-2 and GAD65 in type 1 and type 2 diabetes: isotype restriction and polyclonality

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7 January 2021

Evidence for immunological priming and increased frequency of CD4+ CD25+ cord blood T cells in children born to mothers with type 1 diabetes.

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7 January 2021

IA-2 antibody epitopes and isotypes during the prediabetic process in siblings of children with type 1 diabetes

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7 January 2021

Elimination of dietary gluten does not reduce titers of type 1 diabetes-associated autoantibodies in high-risk subjects

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7 January 2021

The role of viruses in human diabetes.

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7 January 2021

Screening for insulitis in adult autoantibody-positive organ donors

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7 January 2021

Mononuclear cell infiltration and its relation to the expression of major histocompatibility complex antigens and adhesion molecules in pancreas biopsy specimens from newly diagnosed insulin-dependent diabetes mellitus patients

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7 January 2021

Definition of the peptide binding motif within DRB1*1401 restricted epitopes by peptide competition and structural modeling

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7 January 2021

Defective maturation and function of antigen-presenting cells in type 1 diabetes

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7 January 2021

Suppressive effect of glutamic acid decarboxylase 65-specific autoimmune B lymphocytes on processing of T cell determinants located within the antibody epitope

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7 January 2021

Proliferative lymphocyte responses to virus antigens homologous to GAD65 in IDDM.

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7 January 2021

Cloning and primary structure of a human islet isoform of glutamic acid decarboxylase from chromosome 10

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7 January 2021

Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes

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7 January 2021

Report from the 1st International NOD Mouse T-Cell Workshop and the follow-up mini-workshop

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7 January 2021

Unique epitopes of glutamic acid decarboxylase autoantibodies in slowly progressive type 1 diabetes

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7 January 2021

Dynamics of antigen-specific regulatory T-cells in the context of autoimmunity

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7 January 2021

Detection of GAD65-reactive T-Cells in type 1 diabetes by immunoglobulin-free ELISPOT assays

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7 January 2021

Expression in Saccharomyces cerevisiae of antigenically and enzymatically active recombinant glutamic acid decarboxylase.

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7 January 2021

A novel approach to ultrasensitive diagnosis using supramolecular protein nanoparticles.

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7 January 2021

Islet-cell antibodies in diabetes mellitus

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7 January 2021

Immunomodulation with human recombinant autoantigens

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7 January 2021

Islet cell antibodies-theoretical and practical implications

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7 January 2021

Islet-Cell-Surface Antibodies in Juvenile Diabetes Mellitus

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7 January 2021

Antibodies to pancreatic islet cells in insulin-dependent diabetics with coexistent autoimmune disease

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7 January 2021

Antibody to cultured human insulinoma cells in insulin-dependent diabetes

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7 January 2021

MHC Class II tetramers and the pursuit of antigen-specific T cells: define, deviate, delete

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7 January 2021

Targeting T lymphocytes for immune monitoring and intervention in autoimmune diabetes

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7 January 2021

Contribution of glutamate decarboxylase antibodies to the reactivity of islet cell cytoplasmic antibodies

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7 January 2021

The frequency and immunodominance of islet-specific CD8+ T-cell responses change after type 1 diabetes diagnosis and treatment

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7 January 2021

Expression of glutamate decarboxylase isoform, GAD65, in human mononuclear leucocytes: a possible implication of C-terminal end deletion by Western blot and RT-PCR study

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7 January 2021

The World Health Organization International Collaborative Study for islet cell antibodies

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7 January 2021

Abnormal NF-kappa B function characterizes human type 1 diabetes dendritic cells and monocytes

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7 January 2021

Evidence for in vivo primed and expanded autoreactive T cells as a specific feature of patients with type 1 diabetes

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7 January 2021

Detection of autoreactive T cells in type 1 diabetes using coded autoantigens and an immunoglobulin-free cytokine ELISPOT assay: report from the fourth immunology of diabetes society T cell workshop

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7 January 2021

Phosphorylation of serine residues 3, 6, 10, and 13 distinguishes membrane anchored from soluble glutamic acid decarboxylase 65 and is restricted to glutamic acid decarboxylase 65alpha

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7 January 2021

Identification and modulation of a naturally processed T cell epitope from the diabetes-associated autoantigen human glutamic acid decarboxylase 65 (hGAD65).

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7 January 2021

Essential autocrine regulation by IL-21 in the generation of inflammatory T cells

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7 January 2021

The lack of anti-idiotypic antibodies, not the presence of the corresponding autoantibodies to glutamate decarboxylase, defines type 1 diabetes

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7 January 2021

GAD65- and proinsulin-specific CD4+ T-cells detected by MHC class II tetramers in peripheral blood of type 1 diabetes patients and at-risk subjects

1 reference

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7 January 2021

T cells recognize multiple GAD65 and proinsulin epitopes in human type 1 diabetes, suggesting determinant spreading

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7 January 2021

Cross-reactive rubella virus and glutamic acid decarboxylase (65 and 67) protein determinants recognised by T cells of patients with type I diabetes mellitus

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7 January 2021

Recombinant Fabs of human monoclonal antibodies specific to the middle epitope of GAD65 inhibit type 1 diabetes-specific GAD65Abs

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7 January 2021

Is latent autoimmune diabetes in adults distinct from type 1 diabetes or just type 1 diabetes at an older age?

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7 January 2021

Cytotoxic T cells specific for glutamic acid decarboxylase in autoimmune diabetes

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7 January 2021

Detection of glutamic acid decarboxylase (GAD) autoantibodies by indirect immunofluorescence using CHO cells expressing recombinant human GAD65.

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7 January 2021

Progression to type 1 diabetes is associated with a change in the immunoglobulin isotype profile of autoantibodies to glutamic acid decarboxylase (GAD65). Childhood Diabetes in Finland Study Group

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7 January 2021

Autoantibodies in diabetes

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7 January 2021

Autoimmune regulator: from loss of function to autoimmunity.

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7 January 2021

Immunization of diabetes-prone or non-diabetes-prone mice with GAD65 does not induce diabetes or islet cell pathology

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7 January 2021

Preservation of enzyme activity and antigenicity after mutagenesis of the membrane anchoring domain of GAD65.

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7 January 2021

Glutamic acid decarboxylase autoantibody assay using 125I-labelled recombinant GAD65 produced in yeast

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7 January 2021

Self-antigen-presenting cells expressing diabetes-associated autoantigens exist in both thymus and peripheral lymphoid organs

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7 January 2021

Complement-fixing islet cell antibodies in type-1 diabetes can trigger the assembly of the terminal complement complex on human islet cells and are potentially cytotoxic

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7 January 2021

A role for the Hsp90 molecular chaperone family in antigen presentation to T lymphocytes via major histocompatibility complex class II molecules

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7 January 2021

Analysis of GAD65 autoantibodies in Stiff-Person syndrome patients

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7 January 2021

Development of the methylotrophic yeast Pichia methanolica for the expression of the 65 kilodalton isoform of human glutamate decarboxylase

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7 January 2021

GAD65-specific autoantibodies enhance the presentation of an immunodominant T-cell epitope from GAD65.

1 reference

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7 January 2021

Detection of GAD65-specific T-cells by major histocompatibility complex class II tetramers in type 1 diabetic patients and at-risk subjects

1 reference

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7 January 2021

GAD65-specific CD4+ T-cells with high antigen avidity are prevalent in peripheral blood of patients with type 1 diabetes

1 reference

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7 January 2021

Human monoclonal islet cell antibodies from a patient with insulin-dependent diabetes mellitus reveal glutamate decarboxylase as the target antigen

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7 January 2021

Immunoglobulin variable gene analysis of human autoantibodies reveals antigen-driven immune response to glutamate decarboxylase in type 1 diabetes mellitus.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900803-1

7 January 2021

Autoreactive T cell responses in insulin-dependent (Type 1) diabetes mellitus. Report of the first international workshop for standardization of T cell assays

1 reference

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7 January 2021

Prediction of diabetes with body mass index, oral glucose tolerance test and islet cell autoantibodies in a regional population

1 reference

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7 January 2021

Early epitope- and isotype-specific humoral immune responses to GAD65 in young children with genetic susceptibility to type 1 diabetes

1 reference

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7 January 2021

Immunization of non-obese diabetic (NOD) mice with glutamic acid decarboxylase-derived peptide 524-543 reduces cyclophosphamide-accelerated diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900803-1

7 January 2021

Islet antigen specific IL-10+ immune responses but not CD4+CD25+FoxP3+ cells at diagnosis predict glycemic control in type 1 diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900803-1

7 January 2021

T cell responses to type 1 diabetes related peptides sharing homologous regions

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7 January 2021

Dynamic changes of GAD65 autoantibody epitope specificities in individuals at risk of developing type 1 diabetes

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7 January 2021

Autoantibodies in Type 1 diabetes

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7 January 2021

High-resolution autoreactive epitope mapping and structural modeling of the 65 kDa form of human glutamic acid decarboxylase

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7 January 2021

Sites and stages of autoreactive B cell activation and regulation.

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7 January 2021

The idiotypic network in autoimmunity: antibodies that bind antibodies that bind antibodies

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900803-1

7 January 2021

Poor In Vitro Maturation and Pro-Inflammatory Cytokine Response of Dendritic Cells in Children at Genetic Risk of Type 1 Diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900803-1

7 January 2021

A signal located within amino acids 1-27 of GAD65 is required for its targeting to the Golgi complex region

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900803-1

7 January 2021

Antigen presentation of detergent-free glutamate decarboxylase (GAD65) is affected by human serum albumin as carrier protein

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900803-1

7 January 2021

The Environmental Determinants of Diabetes in the Young (TEDDY) study: study design

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900803-1

7 January 2021

Nasal administration of glutamate decarboxylase (GAD65) peptides induces Th2 responses and prevents murine insulin-dependent diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900803-1

7 January 2021

Modulating autoimmune responses to GAD inhibits disease progression and prolongs islet graft survival in diabetes-prone mice

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900803-1

7 January 2021

Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900803-1

7 January 2021

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900803-1

1 reference

7 January 2021

Diabetes Antibody Standardization Program: evaluation of assays for autoantibodies to glutamic acid decarboxylase and islet antigen-2.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900803-1

7 January 2021

HLA-DQ-regulated T-cell responses to islet cell autoantigens insulin and GAD65.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900803-1

7 January 2021

Human B cells secreting immunoglobulin G to glutamic acid decarboxylase-65 from a nondiabetic patient with multiple autoantibodies and Graves' disease: a comparison with those present in type 1 diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900803-1

7 January 2021

Antibodies to glutamic acid decarboxylase and insulin-dependent diabetes in patients with autoimmune polyendocrine syndrome type I.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900803-1

7 January 2021

Comparison of the prevalence of glutamic acid decarboxylase (GAD65) and gliadin antibodies (AGA) in a randomly selected adult estonian population

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900803-1

7 January 2021

Macrophages and dendritic cells infiltrating islets with or without beta cells produce tumour necrosis factor-alpha in patients with recent-onset type 1 diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900803-1

7 January 2021

Viral infections as potential triggers of type 1 diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900803-1

7 January 2021

Enteroviruses and type 1 diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900803-1

7 January 2021

Combined use of autoantibodies (IA-2 autoantibody, GAD autoantibody, insulin autoantibody, cytoplasmic islet cell antibodies) in type 1 diabetes: Combinatorial Islet Autoantibody Workshop

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900803-1

7 January 2021

GAD65-reactive T cells are activated in patients with autoimmune type 1a diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900803-1

7 January 2021

Detection and immunochemical characterization of glutamic acid decarboxylase autoantibodies in patients with autoimmune diabetes mellitus.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900803-1

7 January 2021

Decreased blood dendritic cell counts in type 1 diabetic children

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900803-1

7 January 2021

Dietary risk factors for the emergence of type 1 diabetes-related autoantibodies in 21/2 year-old Swedish children.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900803-1

7 January 2021

Release of glutamate decarboxylase-65 into the circulation by injured pancreatic islet beta-cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900803-1

7 January 2021

B-cell self-tolerance in humans

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900803-1

7 January 2021

Autoantibody markers for the diagnosis and prediction of type 1 diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900803-1

7 January 2021

Autoimmune thyroid disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900803-1

7 January 2021

Naturally processed T cell epitopes from human glutamic acid decarboxylase identified using mice transgenic for the type 1 diabetes-associated human MHC class II allele, DRB1*0401.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900803-1

7 January 2021