Synthesis and antimalarial activity of new chloroquine analogues carrying a multifunctional linear side chain. (Q37358401)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19703776%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

title

Synthesis and antimalarial activity of new chloroquine analogues carrying a multifunctional linear side chain (English)

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6 February 2020

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5

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6 February 2020

author name string

Daniel P Iwaniuk

1

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6 February 2020

Eric D Whetmore

2

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6 February 2020

Nicholas Rosa

3

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6 February 2020

Kekeli Ekoue-Kovi

4

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6 February 2020

Angel C de Dios

6

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6 February 2020

Paul D Roepe

7

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6 February 2020

Christian Wolf

8

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6 February 2020

language of work or name

English

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publication date

8 August 2009

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Bioorganic & Medicinal Chemistry

6 February 2020

published in

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6 February 2020

volume

17

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6 February 2020

issue

18

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6 February 2020

page(s)

6560-6566

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Malaria: progress, perils, and prospects for eradication

6 February 2020

cites work

1 reference

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The global distribution of clinical episodes of Plasmodium falciparum malaria

6 September 2017

1 reference

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Inhibition of heme crystal growth by antimalarials and other compounds: implications for drug discovery

6 September 2017

1 reference

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Chemotherapeutic agents against malaria: what next after chloroquine?

6 September 2017

1 reference

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Medical need, scientific opportunity and the drive for antimalarial drugs

6 September 2017

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The neglected burden of Plasmodium vivax malaria

6 September 2017

1 reference

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The structure of malaria pigment beta-haematin

6 September 2017

1 reference

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Aminoquinolines that circumvent resistance in Plasmodium falciparum in vitro

6 September 2017

1 reference

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4-aminoquinoline analogs of chloroquine with shortened side chains retain activity against chloroquine-resistant Plasmodium falciparum

6 September 2017

1 reference

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Amino acid metabolism and protein synthesis in malarial parasites

6 September 2017

1 reference

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Novel, rapid, and inexpensive cell-based quantification of antimalarial drug efficacy.

6 September 2017

1 reference

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Simple and inexpensive fluorescence-based technique for high-throughput antimalarial drug screening.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2749251

4-Aminoquinolines--past, present, and future: a chemical perspective

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2749251

Synthesis and antimalarial activity of new 4-amino-7-chloroquinolyl amides, sulfonamides, ureas and thioureas

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2749251

Overcoming drug resistance to heme-targeted antimalarials by systematic side chain variation of 7-chloro-4-aminoquinolines

26 June 2018

1 reference

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Assessment and continued validation of the malaria SYBR green I-based fluorescence assay for use in malaria drug screening

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2749251

Crystal nucleation, growth, and morphology of the synthetic malaria pigment beta-hematin and the effect thereon by quinoline additives: the malaria pigment as a target of various antimalarial drugs

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2749251

Structure of the amodiaquine-FPIX mu oxo dimer solution complex at atomic resolution

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2749251

Carbon isosteres of the 4-aminopyridine substructure of chloroquine: effects on pK(a), hematin binding, inhibition of hemozoin formation, and parasite growth

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2749251

Novel short chain chloroquine analogues retain activity against chloroquine resistant K1 Plasmodium falciparum

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2749251

Solution structures of antimalarial drug-heme complexes

26 June 2018

1 reference

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Structure-activity relationships in 4-aminoquinoline antiplasmodials. The role of the group at the 7-position

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2749251

Structure-function relationships in aminoquinolines: effect of amino and chloro groups on quinoline-hematin complex formation, inhibition of beta-hematin formation, and antiplasmodial activity.

26 June 2018

1 reference

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Digestion of the host erythrocyte by malaria parasites is the primary target for quinoline-containing antimalarials

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2749251

4-N-, 4-S-, and 4-O-chloroquine analogues: influence of side chain length and quinolyl nitrogen pKa on activity vs chloroquine resistant malaria

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2749251

10.1016/J.BMC.2009.08.003

2 September 2018

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19703776%20AND%20SRC:MED&resulttype=core&format=json

release_zl6bpkr57fdmdh4c75k7jv7rvu

6 February 2020

Fatcat ID

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mapped directly with Wikidata item

24 November 2022

based on heuristic

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19703776%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

PubMed publication ID

19703776

1 reference