Relaxin, a pleiotropic vasodilator for the treatment of heart failure. (Q37356318)

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18 January 2020

review article

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4 September 2020

3 December 2020

Relaxin, a pleiotropic vasodilator for the treatment of heart failure (English)

1 reference

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18 January 2020

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22 March 2019

17 June 2019

4 September 2020

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17 November 2019

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20 November 2019

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3 December 2020

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Thomas Bernd Dschietzig

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18 January 2020

Gary Felker

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18 January 2020

Marco Metra

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18 January 2020

Gad Cotter

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18 January 2020

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John R Teerlink

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18 January 2020

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Adriaan A Voors

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18 January 2020

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Sam L Teichman

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18 January 2020

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Elaine Unemori

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18 January 2020

author name string

Kirk Conrad

4

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18 January 2020

publication date

20 December 2008

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18 January 2020

1 December 2009

2 references

4 September 2020

3 December 2020

Heart Failure Reviews

6 references

17 June 2019

17 November 2019

20 November 2019

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18 January 2020

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3 December 2020

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18 January 2020

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321-329

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18 January 2020

issue

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https://scigraph.springernature.com/pub.10.1007/s10741-008-9129-3

18 January 2020

exact match

0 references

cites work

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The vascular actions of relaxin

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Relaxin-a pleiotropic hormone and its emerging role for experimental and clinical therapeutics.

6 September 2017

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Relaxin family peptide receptors RXFP1 and RXFP2 modulate cAMP signaling by distinct mechanisms

6 September 2017

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Role of diminished renal function in cardiovascular mortality: marker or pathogenetic factor?

6 September 2017

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Characteristics and outcomes of patients hospitalized for heart failure in the United States: rationale, design, and preliminary observations from the first 100,000 cases in the Acute Decompensated Heart Failure National Registry (ADHERE).

6 September 2017

1 reference

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Emerging role of relaxin in renal and cardiovascular function

6 September 2017

1 reference

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N-terminal pro B type natriuretic peptide, but not the new putative cardiac hormone relaxin, predicts prognosis in patients with chronic heart failure

6 September 2017

1 reference

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Activation of orphan receptors by the hormone relaxin

6 September 2017

1 reference

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Relaxin is a potent renal vasodilator in conscious rats

6 September 2017

1 reference

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Relaxin-induced increased coronary flow through stimulation of nitric oxide production.

6 September 2017

1 reference

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Acute blockade of nitric oxide synthase inhibits renal vasodilation and hyperfiltration during pregnancy in chronically instrumented conscious rats

6 September 2017

1 reference

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The antifibrotic effects of relaxin in human renal fibroblasts are mediated in part by inhibition of the Smad2 pathway

6 September 2017

1 reference

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Multiple binding sites revealed by interaction of relaxin family peptides with native and chimeric relaxin family peptide receptors 1 and 2 (LGR7 and LGR8).

14 September 2017

1 reference

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Phosphoinositide 3-kinase activity is required for biphasic stimulation of cyclic adenosine 3',5'-monophosphate by relaxin

14 September 2017

1 reference

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Pregnancy: an overfill or underfill state

14 September 2017

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Evidence for local relaxin ligand-receptor expression and function in arteries.

14 September 2017

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Is the pregnancy hormone relaxin also a vasodilator peptide secreted by the heart?

26 June 2018

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Relaxin stimulates expression of vascular endothelial growth factor in normal human endometrial cells in vitro and is associated with menometrorrhagia in women

26 June 2018

1 reference

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Relaxin activates the L-arginine-nitric oxide pathway in vascular smooth muscle cells in culture.

26 June 2018

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Relaxin modulates synthesis and secretion of procollagenase and collagen by human dermal fibroblasts

26 June 2018

1 reference

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Intravenous recombinant human relaxin in compensated heart failure: a safety, tolerability, and pharmacodynamic trial.

26 June 2018

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Influence of recombinant human relaxin on renal hemodynamics in healthy volunteers.

2 September 2018

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Relaxin increases cardiac output and reduces systemic arterial load in hypertensive rats.

2 September 2018

1 reference

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Effects of relaxin on systemic arterial hemodynamics and mechanical properties in conscious rats: sex dependency and dose response.

2 September 2018

1 reference

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Relaxin modulates cardiac fibroblast proliferation, differentiation, and collagen production and reverses cardiac fibrosis in vivo.

2 September 2018

1 reference

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Relationship between heart failure treatment and development of worsening renal function among hospitalized patients

2 September 2018

1 reference

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Essential Role for Vascular Gelatinase Activity in Relaxin-Induced Renal Vasodilation, Hyperfiltration, and Reduced Myogenic Reactivity of Small Arteries

2 September 2018

1 reference

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Relaxin, a pregnancy hormone, is a functional endothelin-1 antagonist: attenuation of endothelin-1-mediated vasoconstriction by stimulation of endothelin type-B receptor expression via ERK-1/2 and nuclear factor-kappaB.

2 September 2018

1 reference

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Acute heart failure: a novel approach to its pathogenesis and treatment.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772950

Relaxin activates the MAP kinase pathway in human endometrial stromal cells

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772950

Flow-induced pressure differentially regulates endothelin-1, urotensin II, adrenomedullin, and relaxin in pulmonary vascular endothelium.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772950

The pregnancy hormone relaxin is a player in human heart failure.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2772950

The prognostic implications of renal insufficiency in asymptomatic and symptomatic patients with left ventricular systolic dysfunction.

2 September 2018

1 reference

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Relaxin may be the "elusive" renal vasodilatory agent of normal pregnancy

2 September 2018

1 reference

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Acute heart failure associated with high admission blood pressure - A distinct vascular disorder?

2 September 2018

1 reference

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Impact of gender and endothelin on renal vasodilation and hyperfiltration induced by relaxin in conscious rats

3 December 2018

1 reference

12 December 2020

Comparison of Signaling Pathways Activated by the Relaxin Family Peptide Receptors, RXFP1 and RXFP2, Using Reporter Genes

1 reference

12 December 2020

Negative cooperativity in H2 relaxin binding to a dimeric relaxin family peptide receptor 1

1 reference

12 December 2020

Relaxin gene and protein expression and its regulation of procollagenase and vascular endothelial growth factor in human endometrial cells

1 reference

12 December 2020

Myogenic reactivity is reduced in small renal arteries isolated from relaxin-treated rats

1 reference

12 December 2020

Time course and dose response of relaxin-mediated renal vasodilation, hyperfiltration, and changes in plasma osmolality in conscious rats

1 reference

12 December 2020

Relaxin modifies systemic arterial resistance and compliance in conscious, nonpregnant rats

1 reference

12 December 2020

Serial changes in 24 hour creatinine clearance during normal menstrual cycles and the first trimester of pregnancy

1 reference

12 December 2020

Blunted responses to vasoconstrictors in mesenteric vasculature but not in portal vein of spontaneously hypertensive rats treated with relaxin

1 reference

12 December 2020

Effects of relaxin on the endothelium of endometrial blood vessels in monkeys (Macaca mulatta)

1 reference

12 December 2020

Relaxin stimulates atrial natriuretic peptide secretion in perfused rat heart

1 reference

12 December 2020

Contribution of endogenous endothelin-1 to the maintenance of vascular tone: role of nitric oxide

1 reference

12 December 2020

Demonstration of a relaxin receptor and relaxin-stimulated tyrosine phosphorylation in human lower uterine segment fibroblasts

1 reference

12 December 2020

Identification of specific relaxin-binding cells in the human female

1 reference

12 December 2020

Endothelin mediates renal vasodilation and hyperfiltration during pregnancy in chronically instrumented conscious rats

1 reference

12 December 2020

10.1007/S10741-008-9129-3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19101795%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19101795%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

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