Biological activity of lycopene metabolites: implications for cancer prevention. (Q37329396)

19 August 2017

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title

Biological activity of lycopene metabolites: implications for cancer prevention (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6824483&resulttype=core&format=json

12 May 2020

2

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12 May 2020

author name string

Jonathan R Mein

series ordinal

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6824483&resulttype=core&format=json

12 May 2020

Xiang-Dong Wang

series ordinal

3

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12 May 2020

publication date

1 December 2008

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19 August 2017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6824483&resulttype=core&format=json

12 May 2020

volume

66

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6824483&resulttype=core&format=json

12 May 2020

page(s)

667-683

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6824483&resulttype=core&format=json

12 May 2020

issue

12

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Prostate carcinogenesis in N-methyl-N-nitrosourea (NMU)-testosterone-treated rats fed tomato powder, lycopene, or energy-restricted diets

12 May 2020

cites work

1 reference

https://api.crossref.org/works/10.1111%2FJ.1753-4887.2008.00120.X

Retinoid metabolism and nuclear receptor responses: New insights into coordinated regulation of the PPAR-RXR complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1753-4887.2008.00120.X

Separation and identification of carotenoids and their oxidation products in the extracts of human plasma

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1753-4887.2008.00120.X

Participation of lycopene and beta-carotene in carcinogenesis: defenders, aggressors, or passive bystanders?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1753-4887.2008.00120.X

Are dietary influences on the risk of prostate cancer mediated through the insulin-like growth factor system?

21 January 2018

1 reference

12 December 2020

Activation of the Nrf2-ARE signaling pathway: a promising strategy in cancer prevention

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12 December 2020

Tomato sauce supplementation and prostate cancer: lycopene accumulation and modulation of biomarkers of carcinogenesis.

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12 December 2020

Variations in plasma lycopene and specific isomers over time in a cohort of U.S. men

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12 December 2020

beta-Carotene absorption and cleavage in rats is affected by the vitamin A concentration of the diet

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12 December 2020

Lutein, lycopene, and their oxidative metabolites in chemoprevention of cancer

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12 December 2020

Dose-response effects of lycopene on selected drug-metabolizing and antioxidant enzymes in the rat

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12 December 2020

Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice

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12 December 2020

Cis-lycopene is more bioavailable than trans-lycopene in vitro and in vivo in lymph-cannulated ferrets

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12 December 2020

Combinations of tomato and broccoli enhance antitumor activity in dunning r3327-h prostate adenocarcinomas.

1 reference

12 December 2020

Membrane-associated insulin-like growth factor-binding protein-3 inhibits insulin-like growth factor-I-induced insulin-like growth factor-I receptor signaling in ishikawa endometrial cancer cells

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12 December 2020

Deregulation of the IGF axis in cancer: epidemiological evidence and potential therapeutic interventions

1 reference

12 December 2020

Growth inhibition of human hepatoma cells by acyclic retinoid is associated with induction of p21(CIP1) and inhibition of expression of cyclin D1.

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12 December 2020

Prospective study of colorectal cancer risk in men and plasma levels of insulin-like growth factor (IGF)-I and IGF-binding protein-3.

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12 December 2020

Enzymatic and oxidative metabolites of lycopene

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12 December 2020

Lycopene inhibition of IGF-induced cancer cell growth depends on the level of cyclin D1.

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12 December 2020

Modulation of metabolic enzymes by dietary phytochemicals: a review of mechanisms underlying beneficial versus unfavorable effects

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12 December 2020

Expression and characterization of a murine enzyme able to cleave beta-carotene. The formation of retinoids

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12 December 2020

Lycopene inhibits the growth of normal human prostate epithelial cells in vitro

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12 December 2020

Feedback regulation of beta,beta-carotene 15,15'-monooxygenase by retinoic acid in rats and chickens

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12 December 2020

Effects of a lycopene-rich diet on spontaneous and benzo[a]pyrene-induced mutagenesis in prostate, colon and lungs of the lacZ mouse

1 reference

12 December 2020

Antioxidant activities of carotenes and xanthophylls

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12 December 2020

Retinoids in cancer therapy and chemoprevention: promise meets resistance

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12 December 2020

Lycopene oxidation product enhances gap junctional communication

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12 December 2020

Identification of beta-carotene 15, 15'-monooxygenase as a peroxisome proliferator-activated receptor target gene

1 reference

12 December 2020

Plasma insulin-like growth factor-I and prostate cancer risk: a prospective study

1 reference

12 December 2020

Lycopene supplementation inhibits lung squamous metaplasia and induces apoptosis via up-regulating insulin-like growth factor-binding protein 3 in cigarette smoke-exposed ferrets.

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12 December 2020

Lycopene as the most efficient biological carotenoid singlet oxygen quencher

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12 December 2020

High dose lycopene supplementation increases hepatic cytochrome P4502E1 protein and inflammation in alcohol-fed rats

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12 December 2020

Stimulation of gap junctional communication: comparison of acyclo-retinoic acid and lycopene

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12 December 2020

Characterization of beta-apo-13-carotenone and beta-apo-14'-carotenal as enzymatic products of the excentric cleavage of beta-carotene

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12 December 2020

Carotenoids affect proliferation of human prostate cancer cells.

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12 December 2020

Cleavage products of lycopene produced by in vitro oxidations: characterization and mechanisms of formation

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12 December 2020

Enzymatic metabolites of lycopene induce Nrf2-mediated expression of phase II detoxifying/antioxidant enzymes in human bronchial epithelial cells

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12 December 2020

Chemoprotection against cancer by induction of phase 2 enzymes

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12 December 2020

Identification, quantification, and relative concentrations of carotenoids and their metabolites in human milk and serum.

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12 December 2020

Novel lycopene metabolites are detectable in plasma of preruminant calves after lycopene supplementation

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12 December 2020

β-Cryptoxanthin suppresses the growth of immortalized human bronchial epithelial cells and non-small-cell lung cancer cells and up-regulates retinoic acid receptor β expression

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12 December 2020

BIOSYNTHESIS OF VITAMIN A WITH RAT INTESTINAL ENZYMES

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12 December 2020

Lycopene interferes with cell cycle progression and insulin-like growth factor I signaling in mammary cancer cells

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12 December 2020

Oxidative DNA damage in prostate cancer patients consuming tomato sauce-based entrees as a whole-food intervention.

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12 December 2020

Insulin-like growth factor-I and binding protein-3 and risk of cancer

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12 December 2020

Lycopene supplementation prevents smoke-induced changes in p53, p53 phosphorylation, cell proliferation, and apoptosis in the gastric mucosa of ferrets.

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12 December 2020

Apo-8'-lycopenal and apo-12'-lycopenal are metabolic products of lycopene in rat liver

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12 December 2020

Cooperation between MEF2 and PPARgamma in human intestinal beta,beta-carotene 15,15'-monooxygenase gene expression

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12 December 2020

Dietary correlates of plasma insulin-like growth factor I and insulin-like growth factor binding protein 3 concentrations.

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12 December 2020

Does tomato consumption effectively increase the resistance of lymphocyte DNA to oxidative damage?

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12 December 2020

Importance of phase 2 gene regulation in protection against electrophile and reactive oxygen toxicity and carcinogenesis

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12 December 2020

Prevention of second primary tumors by an acyclic retinoid, polyprenoic acid, in patients with hepatocellular carcinoma. Hepatoma Prevention Study Group

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12 December 2020

Dietary lycopene downregulates carotenoid 15,15'-monooxygenase and PPAR-gamma in selected rat tissues.

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12 December 2020

Effects of physiological versus pharmacological beta-carotene supplementation on cell proliferation and histopathological changes in the lungs of cigarette smoke-exposed ferrets.

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12 December 2020

Biogenesis of retinoic acid from beta-carotene. Differences between the metabolism of beta-carotene and retinal

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12 December 2020

Intestinal uptake and lymphatic absorption of beta-carotene in ferrets: a model for human beta-carotene metabolism

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12 December 2020

Identification and characterization of a mammalian enzyme catalyzing the asymmetric oxidative cleavage of provitamin A

1 reference

12 December 2020

Connexins as targets for cancer chemoprevention and chemotherapy

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12 December 2020

Retinoid agonist activities of synthetic geranyl geranoic acid derivatives

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12 December 2020

Effects of acyclo-retinoic acid and lycopene on activation of the retinoic acid receptor and proliferation of mammary cancer cells.

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12 December 2020

Identification, expression, and substrate specificity of a mammalian beta-carotene 15,15'-dioxygenase

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12 December 2020

Induction of connexin 43 by carotenoids: functional consequences

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12 December 2020

Cell Cycle Arrest and Induction of Apoptosis by Lycopene in LNCaP Human Prostate Cancer Cells

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12 December 2020

Chemopreventive efficacy of lycopene on 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis

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12 December 2020

Retinoid signaling and activator protein-1 expression in ferrets given beta-carotene supplements and exposed to tobacco smoke.

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12 December 2020

The enzymatic cleavage of beta-carotene into vitamin A by soluble enzymes of rat liver and intestine

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12 December 2020

Asymmetric cleavage of beta-carotene yields a transcriptional repressor of retinoid X receptor and peroxisome proliferator-activated receptor responses

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12 December 2020

A decade of molecular biology of retinoic acid receptors

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12 December 2020

Circulating concentrations of insulin-like growth factor I and risk of breast cancer

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12 December 2020

Formation of cleavage products by autoxidation of lycopene

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12 December 2020

Moderate intervention with carotenoid-rich vegetable products reduces lipid peroxidation in men

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12 December 2020

Lycopene inhibition of cell cycle progression in breast and endometrial cancer cells is associated with reduction in cyclin D levels and retention of p27(Kip1) in the cyclin E-cdk2 complexes

1 reference

12 December 2020

Lymphocyte lycopene concentration and DNA protection from oxidative damage is increased in women after a short period of tomato consumption

1 reference

12 December 2020

Expression pattern and localization of beta,beta-carotene 15,15'-dioxygenase in different tissues

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12 December 2020

Diverse carotenoids protect against chemically induced neoplastic transformation

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12 December 2020

Beta-oxidation in rabbit liver in vitro and in the perfused ferret liver contributes to retinoic acid biosynthesis from beta-apocarotenoic acids

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12 December 2020

Carotenoids activate the antioxidant response element transcription system.

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12 December 2020

Enhancement of gap junctional communication by retinoids correlates with their ability to inhibit neoplastic transformation

1 reference

12 December 2020

Can smoke-exposed ferrets be utilized to unravel the mechanisms of action of lycopene?

1 reference

12 December 2020

Chemistry, distribution, and metabolism of tomato carotenoids and their impact on human health

1 reference

12 December 2020

Filling the gap in vitamin A research. Molecular identification of an enzyme cleaving beta-carotene to retinal

1 reference

12 December 2020

Biosynthesis of 9-cis-retinoic acid from 9-cis-beta-carotene in human intestinal mucosa in vitro

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12 December 2020

beta-Carotene conversion into vitamin A in human retinal pigment epithelial cells

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12 December 2020

Lycopenoids: are lycopene metabolites bioactive?

1 reference

12 December 2020

Apo-10'-lycopenoic acid inhibits lung cancer cell growth in vitro, and suppresses lung tumorigenesis in the A/J mouse model in vivo.

1 reference

12 December 2020

Tomato lycopene and low density lipoprotein oxidation: a human dietary intervention study

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12 December 2020

The singlet oxygen and carotenoid interaction

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12 December 2020

Cell type-specific expression of beta-carotene 9',10'-monooxygenase in human tissues

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12 December 2020

Nutritional status affects intestinal carotene cleavage activity and carotene conversion to vitamin A in rats

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12 December 2020

Beta-carotene and beta-apo-14'-carotenoic acid prevent the reduction of retinoic acid receptor beta in benzo[a]pyrene-treated normal human bronchial epithelial cells.

1 reference

12 December 2020

Tomatoes, tomato-based products, lycopene, and cancer: review of the epidemiologic literature

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12 December 2020

Retinaldehyde represses adipogenesis and diet-induced obesity.

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12 December 2020

Cloning and expression of beta,beta-carotene 15,15'-dioxygenase

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12 December 2020

The biochemical characterization of ferret carotene-9',10'-monooxygenase catalyzing cleavage of carotenoids in vitro and in vivo

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12 December 2020

Lycopene inhibits proliferation and enhances gap-junction communication of KB-1 human oral tumor cells.

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12 December 2020

Carotenoid actions and their relation to health and disease

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12 December 2020

Enzymatic conversion of beta-carotene into beta-apo-carotenals and retinoids by human, monkey, ferret, and rat tissues

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12 December 2020

A novel cleavage product formed by autoxidation of lycopene induces apoptosis in HL-60 cells

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12 December 2020

Induction of phase I, II and III drug metabolism/transport by xenobiotics

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12 December 2020

Physiologically attainable concentrations of lycopene induce mitochondrial apoptosis in LNCaP human prostate cancer cells.

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12 December 2020

Acyclic carotenoids and their oxidation mixtures inhibit the growth of HL-60 human promyelocytic leukemia cells

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12 December 2020

Lycopene affects proliferation and apoptosis of four malignant cell lines

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12 December 2020

Cloning and characterization of a human beta,beta-carotene-15,15'-dioxygenase that is highly expressed in the retinal pigment epithelium

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12 December 2020

Key role of conserved histidines in recombinant mouse beta-carotene 15,15'-monooxygenase-1 activity

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12 December 2020

Effects of canthaxanthin, astaxanthin, lycopene and lutein on liver xenobiotic-metabolizing enzymes in the rat

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12 December 2020

Lycopene and vitamin E interfere with autocrine/paracrine loops in the Dunning prostate cancer model

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12 December 2020

Carotenoids up-regulate connexin43 gene expression independent of their provitamin A or antioxidant properties

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12 December 2020

CMO1 deficiency abolishes vitamin A production from beta-carotene and alters lipid metabolism in mice

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12 December 2020

Lycopene is a more potent inhibitor of human cancer cell proliferation than either alpha-carotene or beta-carotene

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12 December 2020

cis-trans lycopene isomers, carotenoids, and retinol in the human prostate

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12 December 2020

A review of epidemiologic studies of tomatoes, lycopene, and prostate cancer

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12 December 2020

Carotenoids enhance gap junctional communication and inhibit lipid peroxidation in C3H/10T1/2 cells: relationship to their cancer chemopreventive action

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12 December 2020

Acyclo-retinoic acid induces apoptosis in human prostate cancer cells

1 reference

12 December 2020

Lycopene inhibits experimental metastasis of human hepatoma SK-Hep-1 cells in athymic nude mice

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12 December 2020

Lycopene supplementation elevates circulating insulin-like growth factor binding protein-1 and -2 concentrations in persons at greater risk of colorectal cancer

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12 December 2020

Epigenetic toxicology as toxicant-induced changes in intracellular signalling leading to altered gap junctional intercellular communication

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12 December 2020

Lycopene induces apoptosis in immortalized fibroblasts exposed to tobacco smoke condensate through arresting cell cycle and down-regulating cyclin D1, pAKT and pBad.

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12 December 2020

The structure of a retinal-forming carotenoid oxygenase

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12 December 2020

Role of insulin-like growth factor binding proteins in the control of IGF actions

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12 December 2020

Role of the insulin-like growth factor family in cancer development and progression

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12 December 2020

The promise of retinoids to fight against cancer.

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12 December 2020

Retinoid-enhanced gap junctional communication is achieved by increased levels of connexin 43 mRNA and protein

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12 December 2020

Separation and quantification of carotenoids in human plasma

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12 December 2020

Biochemical properties of purified recombinant human beta-carotene 15,15'-monooxygenase

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12 December 2020

Tomatoes, lycopene, and prostate cancer

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12 December 2020

Enzymatic formation of 9-cis, 13-cis, and all-trans retinals from isomers of beta-carotene

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12 December 2020

In vitro binding affinity of novel synthetic polyprenoids (polyprenoic acids) to cellular retinoid-binding proteins

1 reference

12 December 2020

10.1111/J.1753-4887.2008.00120.X

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6824483&resulttype=core&format=json

12 May 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6824483&resulttype=core&format=json

12 May 2020

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