The impact of transgenic IGF-IR overexpression on mammary development and tumorigenesis (Q37323439)

19 August 2017

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title

The impact of transgenic IGF-IR overexpression on mammary development and tumorigenesis (English)

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19 August 2017

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Robert A Jones

1

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PubMed ID

19002570

19 August 2017

Roger A Moorehead

series ordinal

2

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19 August 2017

11 November 2008

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Journal of Mammary Gland Biology and Neoplasia

19 August 2017

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19 August 2017

13

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19 August 2017

407-413

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19 August 2017

4

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https://scigraph.springernature.com/pub.10.1007/s10911-008-9097-1

19 August 2017

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cites work

Mammary cancer in transgenic mice expressing insulin-like growth factor II (IGF-II)

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Oncogenic transformation by the signaling adaptor proteins insulin receptor substrate (IRS)-1 and IRS-2

21 January 2018

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Elevated insulin-like growth factor-I receptor (IGF-IR) levels in primary breast tumors associated with BRCA1 mutations

21 January 2018

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Tumor development by transgenic expression of a constitutively active insulin-like growth factor I receptor

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12 December 2020

Transitions between epithelial and mesenchymal states in development and disease

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12 December 2020

Targeted disruption of the IGF-I receptor gene decreases cellular proliferation in mammary terminal end buds

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12 December 2020

Overexpression of des(1-3) insulin-like growth factor 1 in the mammary glands of transgenic mice delays the loss of milk production with prolonged lactation

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12 December 2020

Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice

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12 December 2020

Expression of insulin-like growth factor-I receptor, estrogen receptor alpha, Bcl-2 and Bax proteins in human breast cancer

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12 December 2020

Characterization of a novel primary mammary tumor cell line reveals that cyclin D1 is regulated by the type I insulin-like growth factor receptor.

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12 December 2020

Transgenic hypersecretion of des(1-3) human insulin-like growth factor I in mouse milk has limited effects on the gastrointestinal tract in suckling pups

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Elevated insulin-like growth factor I receptor autophosphorylation and kinase activity in human breast cancer.

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A novel doxycycline-inducible system for the transgenic analysis of mammary gland biology

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Protective effects of pregnancy and lactation against N-methyl-N-nitrosourea-induced mammary carcinomas in female Lewis rats.

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Increased Milk Yield in Transgenic Mice Expressing Insulin-like Growth Factor 1

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Lack of sustained regression of c-MYC-induced mammary adenocarcinomas following brief or prolonged MYC inactivation

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Distinct roles of Akt1 and Akt2 in regulating cell migration and epithelial-mesenchymal transition

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P190-B Rho GTPase-activating protein overexpression disrupts ductal morphogenesis and induces hyperplastic lesions in the developing mammary gland

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Insulin-like growth factors and breast cancer

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Paracrine overexpression of insulin-like growth factor-1 enhances mammary tumorigenesis in vivo

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Mammary tumorigenesis and metastasis caused by overexpression of insulin receptor substrate 1 (IRS-1) or IRS-2

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12 December 2020

Conditional activation of Neu in the mammary epithelium of transgenic mice results in reversible pulmonary metastasis

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12 December 2020

Reversibility and recurrence of IGF-IR-induced mammary tumors

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12 December 2020

Elevated expression of activated forms of Neu/ErbB-2 and ErbB-3 are involved in the induction of mammary tumors in transgenic mice: implications for human breast cancer

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Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene

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Expression of the insulin-like growth factor I receptor and urokinase plasminogen activator in breast cancer is associated with poor survival: potential for intervention with 17-allylamino geldanamycin

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12 December 2020

Isoform-specific ras activation and oncogene dependence during MYC- and Wnt-induced mammary tumorigenesis

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12 December 2020

Inability of overexpressed des(1-3)human insulin-like growth factor I (IGF-I) to inhibit forced mammary gland involution is associated with decreased expression of IGF signaling molecules

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12 December 2020

Expression of ovine insulin-like growth factor-1 (IGF-1) stimulates alveolar bud development in mammary glands of transgenic mice

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The insulin-like growth factor system in advanced breast cancer

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Ductal growth is impeded in mammary glands of C-neu transgenic mice.

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Cooperative interaction between mutant p53 and des(1-3)IGF-I accelerates mammary tumorigenesis

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Involution of the lactating mammary gland is inhibited by the IGF system in a transgenic mouse model

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Dose-dependent oncogene-induced senescence in vivo and its evasion during mammary tumorigenesis.

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Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)

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Constitutively active type I insulin-like growth factor receptor causes transformation and xenograft growth of immortalized mammary epithelial cells and is accompanied by an epithelial-to-mesenchymal transition mediated by NF-kappaB and snail

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Metastasizing mammary carcinomas in H19 enhancers-Igf2 transgenic mice

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Breast cancer incidence among atomic bomb survivors, Hiroshima and Nagasaki, 1950-69

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ErbB2 is required for ductal morphogenesis of the mammary gland

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Inhibition of mammary epithelial apoptosis and sustained phosphorylation of Akt/PKB in MMTV-IGF-II transgenic mice

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12 December 2020

Epithelial--mesenchymal and mesenchymal--epithelial transitions in carcinoma progression.

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12 December 2020

Targeted expression of des(1-3) human insulin-like growth factor I in transgenic mice influences mammary gland development and IGF-binding protein expression

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12 December 2020

Transgenic overexpression of IGF-IR disrupts mammary ductal morphogenesis and induces tumor formation

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12 December 2020

IGF-II induces rapid beta-catenin relocation to the nucleus during epithelium to mesenchyme transition

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12 December 2020

Spontaneous mammary adenocarcinomas in transgenic mice that carry and express MTV/myc fusion genes

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12 December 2020

Insulin-like growth factor-I and insulin-like growth factor binding protein-3 inhibit involution of the mammary gland following lactation: studies in transgenic mice

1 reference

12 December 2020

The protective role of pregnancy in breast cancer

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12 December 2020

The transcriptional repressor Snail promotes mammary tumor recurrence

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12 December 2020

The IGF-I receptor in mitogenesis and transformation of mouse embryo cells: role of receptor number

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12 December 2020

Type I insulin-like growth factor receptor over-expression induces proliferation and anti-apoptotic signaling in a three-dimensional culture model of breast epithelial cells

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12 December 2020

Epithelial-mesenchymal transitions in tumour progression

1 reference

12 December 2020

10.1007/S10911-008-9097-1

Identifiers

DOI

1 reference

release_bpbrbp4ea5gfljtun7nzu7bwzu

19 August 2017

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Fatcat

https://api.fatcat.wiki/v0/release/bpbrbp4ea5gfljtun7nzu7bwzu

24 November 2022

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PubMed ID

19002570

1 reference

PubMed ID

19002570