Small interfering RNA-directed knockdown of uracil DNA glycosylase induces apoptosis and sensitizes human prostate cancer cells to genotoxic stress (Q37314482)

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scientific article published on 11 August 2009

Language	Label	Description	Also known as
English	Small interfering RNA-directed knockdown of uracil DNA glycosylase induces apoptosis and sensitizes human prostate cancer cells to genotoxic stress	scientific article published on 11 August 2009

Statements

scholarly article

1 reference

Europe PubMed Central

19 August 2017

Small interfering RNA-directed knockdown of uracil DNA glycosylase induces apoptosis and sensitizes human prostate cancer cells to genotoxic stress (English)

1 reference

Europe PubMed Central

19 August 2017

apoptotic process

0 references

1 reference

based on heuristic

inferred from title

prostate cancer

1 reference

based on heuristic

inferred from title

4

object named as

Jasti S. Rao

author given names

Jasti S.

author last names

Rao

1 reference

Europe PubMed Central

19 August 2017

author name string

Sai Murali Krishna Pulukuri

1

1 reference

Europe PubMed Central

19 August 2017

James A Knost

2

1 reference

Europe PubMed Central

19 August 2017

Norman Estes

3

1 reference

Europe PubMed Central

19 August 2017

publication date

11 August 2009

1 reference

Europe PubMed Central

19 August 2017

number of pages

9

1 reference

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inferred from page(s)

Molecular Cancer Research

1 reference

Europe PubMed Central

19 August 2017

7

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Europe PubMed Central

19 August 2017

8

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Europe PubMed Central

19 August 2017

1285-1293

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Europe PubMed Central

19 August 2017

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2730435/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

A synthetic lethal siRNA screen identifying genes mediating sensitivity to a PARP inhibitor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730435

6 September 2017

p53: a guide to apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730435

6 September 2017

Genetic changes and DNA damage responses in the prostate

1 reference

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6 September 2017

DNA repair pathways as targets for cancer therapy

1 reference

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5-Fluorouracil incorporated into DNA is excised by the Smug1 DNA glycosylase to reduce drug cytotoxicity

1 reference

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6 September 2017

The emerging role of DNA repair proteins as predictive, prognostic and therapeutic targets in cancer

1 reference

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C --> T mutagenesis and gamma-radiation sensitivity due to deficiency in the Smug1 and Ung DNA glycosylases

1 reference

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6 September 2017

Suppression of uracil-DNA glycosylase induces neuronal apoptosis

1 reference

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6 September 2017

Oxidative DNA damage: mechanisms, mutation, and disease

1 reference

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Uracil in DNA--occurrence, consequences and repair

1 reference

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6 September 2017

hUNG2 is the major repair enzyme for removal of uracil from U:A matches, U:G mismatches, and U in single-stranded DNA, with hSMUG1 as a broad specificity backup

1 reference

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6 September 2017

p53 regulation of DNA excision repair pathways

1 reference

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6 September 2017

Base excision repair in a network of defence and tolerance

1 reference

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6 September 2017

p53 modulates base excision repair activity in a cell cycle-specific manner after genotoxic stress.

1 reference

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6 September 2017

Quality control by DNA repair

1 reference

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6 September 2017

p53 and apoptosis

1 reference

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The dual role model for p53 in maintaining genomic integrity

1 reference

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A model for p53-induced apoptosis

1 reference

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1 reference

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p53 in signaling checkpoint arrest or apoptosis

1 reference

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Novel activities of human uracil DNA N-glycosylase for cytosine-derived products of oxidative DNA damage

1 reference

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Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

1 reference

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Human mitochondrial uracil-DNA glycosylase preform (UNG1) is processed to two forms one of which is resistant to inhibition by AP sites

1 reference

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14 September 2017

Nuclear and mitochondrial splice forms of human uracil-DNA glycosylase contain a complex nuclear localisation signal and a strong classical mitochondrial localisation signal, respectively

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730435

14 September 2017

Impairment of the DNA repair and growth arrest pathways by p53R2 silencing enhances DNA damage-induced apoptosis in a p53-dependent manner in prostate cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730435

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Involvement of sphingosine kinase 2 in p53-independent induction of p21 by the chemotherapeutic drug doxorubicin

1 reference

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The alpha6beta4 integrin maintains the survival of human breast carcinoma cells in vivo

1 reference

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Transient adenoviral N-methylpurine DNA glycosylase overexpression imparts chemotherapeutic sensitivity to human breast cancer cells

1 reference

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14 September 2017

Cellular repair of oxidatively induced DNA base lesions is defective in prostate cancer cell lines, PC-3 and DU-145.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730435

14 September 2017

Imbalancing the DNA base excision repair pathway in the mitochondria; targeting and overexpressing N-methylpurine DNA glycosylase in mitochondria leads to enhanced cell killing.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730435

14 September 2017

The presence of nuclear and mitochondrial uracil-DNA glycosylase in extracts of human KB cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730435

14 September 2017

Differential expression of cell death regulators in response to thapsigargin and adriamycin in Bcl-2 transfected DU145 prostatic cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730435

28 September 2017

Increased spontaneous mutation frequency in human cells expressing the phage PBS2-encoded inhibitor of uracil-DNA glycosylase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730435

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Attenuation of G2 checkpoint function precedes human cell immortalization.

1 reference

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28 September 2017

Different organization of base excision repair of uracil in DNA in nuclei and mitochondria and selective upregulation of mitochondrial uracil-DNA glycosylase after oxidative stress.

1 reference

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2 September 2018

Disruption of gene expression and induction of apoptosis in prostate cancer cells by a DNA-damaging agent tethered to an androgen receptor ligand

1 reference

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2 September 2018

Depletion of uracil-DNA glycosylase activity is associated with decreased cell proliferation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730435

2 September 2018

Activation of p53/p21Waf1/Cip1 pathway by 5-aza-2'-deoxycytidine inhibits cell proliferation, induces pro-apoptotic genes and mitogen-activated protein kinases in human prostate cancer cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730435

2 September 2018

HIV-1-associated uracil DNA glycosylase activity controls dUTP misincorporation in viral DNA and is essential to the HIV-1 life cycle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730435

2 September 2018

p53 functions in the incorporation step in DNA base excision repair in mouse liver mitochondria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730435

2 September 2018

Base excision repair intermediates induce p53-independent cytotoxic and genotoxic responses.

1 reference

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2 September 2018

Importance of uracil DNA glycosylase in Pseudomonas aeruginosa and Mycobacterium smegmatis, G+C-rich bacteria, in mutation prevention, tolerance to acidified nitrite, and endurance in mouse macrophages

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2730435

2 September 2018

A p53-independent Pathway for Activation of WAF1/CIP1 Expression Following Oxidative Stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/19671688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Direct involvement of p53 in the base excision repair pathway of the DNA repair machinery

1 reference

https://pubmed.ncbi.nlm.nih.gov/19671688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1158/1541-7786.MCR-08-0508

1 reference

Europe PubMed Central

19 August 2017

1 reference

Europe PubMed Central

19 August 2017

1 reference

Europe PubMed Central

19 August 2017

ResearchGate publication ID

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