Allergy therapy: the therapeutic potential of targeting sphingosine kinase signalling in mast cells (Q37299499)

19 August 2017

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title

Allergy therapy: the therapeutic potential of targeting sphingosine kinase signalling in mast cells (English)

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19 August 2017

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Alirio J Melendez

1

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PubMed ID

18924207

19 August 2017

language of work or name

English

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publication date

1 November 2008

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European Journal of Immunology

19 August 2017

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19 August 2017

38

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19 August 2017

11

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19 August 2017

2969-2974

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Sphingosine kinase signalling in immune cells: potential as novel therapeutic targets

19 August 2017

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838642

Antisense knockdown of sphingosine kinase 1 in human macrophages inhibits C5a receptor-dependent signal transduction, Ca2+ signals, enzyme release, cytokine production, and chemotaxis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838642

Homodimerization and heterodimerization of S1P/EDG sphingosine-1-phosphate receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838642

Interleukin-4, -5, and -6 and tumor necrosis factor-alpha in normal and asthmatic airways: evidence for the human mast cell as a source of these cytokines

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838642

The role of sphingosine kinase in a murine model of allergic asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838642

Cutting edge: Alternative signaling of Th17 cell development by sphingosine 1-phosphate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838642

21 January 2018

Pathogenesis of asthma

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838642

7 January 2021

Calcium mobilization via sphingosine kinase in signalling by the Fc epsilon RI antigen receptor

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838642

7 January 2021

Dichotomy of Ca2+ signals triggered by different phospholipid pathways in antigen stimulation of human mast cells

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838642

7 January 2021

Transactivation of sphingosine-1-phosphate receptors by FcepsilonRI triggering is required for normal mast cell degranulation and chemotaxis

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838642

7 January 2021

IgE-dependent activation of sphingosine kinases 1 and 2 and secretion of sphingosine 1-phosphate requires Fyn kinase and contributes to mast cell responses

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838642

7 January 2021

Sphingolipids and the regulation of the immune response

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838642

7 January 2021

Regulation and functional roles of sphingosine kinases

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838642

7 January 2021

Functions of the multifaceted family of sphingosine kinases and some close relatives

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838642

7 January 2021

Sphingosine 1-phosphate, a key cell signaling molecule

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838642

7 January 2021

Sphingosine 1-phosphate and its receptors: an autocrine and paracrine network

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838642

7 January 2021

FcgammaRI coupling to phospholipase D initiates sphingosine kinase-mediated calcium mobilization and vesicular trafficking

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838642

7 January 2021

A molecular switch changes the signalling pathway used by the Fc gamma RI antibody receptor to mobilise calcium

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838642

7 January 2021

Formyl peptide receptor signaling in HL-60 cells through sphingosine kinase

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838642

7 January 2021

Anaphylatoxin signaling in human neutrophils. A key role for sphingosine kinase

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838642

7 January 2021

Platelet-derived growth factor-induced activation of sphingosine kinase requires phosphorylation of the PDGF receptor tyrosine residue responsible for binding of PLCgamma

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838642

7 January 2021

Sphingosine-1-phosphate inhibits PDGF-induced chemotaxis of human arterial smooth muscle cells: spatial and temporal modulation of PDGF chemotactic signal transduction

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838642

7 January 2021

Tumor necrosis factor- induces adhesion molecule expression through the sphingosine kinase pathway

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838642

7 January 2021

Sphingosine kinase 1 regulates pro-inflammatory responses triggered by TNFalpha in primary human monocytes

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838642

7 January 2021

Sphingosine 1-phosphate released from platelets during clotting accounts for the potent endothelial cell chemotactic activity of blood serum and provides a novel link between hemostasis and angiogenesis.

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838642

7 January 2021

Sphingosine 1-phosphate may be a major component of plasma lipoproteins responsible for the cytoprotective actions in human umbilical vein endothelial cells

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838642

7 January 2021

Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838642

7 January 2021

Dual actions of sphingosine-1-phosphate: extracellular through the Gi-coupled receptor Edg-1 and intracellular to regulate proliferation and survival

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838642

7 January 2021

Diversity of cellular receptors and functions for the lysophospholipid growth factors lysophosphatidic acid and sphingosine 1-phosphate.

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838642

7 January 2021

Comparison of intrinsic activities of the putative sphingosine 1-phosphate receptor subtypes to regulate several signaling pathways in their cDNA-transfected Chinese hamster ovary cells

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838642

7 January 2021

Lysophospholipids--receptor revelations

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838642

7 January 2021

Molecular cloning and functional characterization of murine sphingosine kinase

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838642

7 January 2021

Human sphingosine kinase: molecular cloning, functional characterization and tissue distribution

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838642

7 January 2021

Human sphingosine kinase: purification, molecular cloning and characterization of the native and recombinant enzymes

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838642

7 January 2021

Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838642

7 January 2021

The balance between sphingosine and sphingosine-1-phosphate is decisive for mast cell activation after Fc epsilon receptor I triggering

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838642

7 January 2021

The sphingosine kinase-sphingosine-1-phosphate axis is a determinant of mast cell function and anaphylaxis

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838642

7 January 2021

Distinct roles of sphingosine kinases 1 and 2 in human mast-cell functions

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838642

7 January 2021

Genome-wide gene expression profiling of human mast cells stimulated by IgE or FcepsilonRI-aggregation reveals a complex network of genes involved in inflammatory responses

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838642

7 January 2021

Inhibition of Fc epsilon RI-mediated mast cell responses by ES-62, a product of parasitic filarial nematodes

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838642

7 January 2021

Role of mast cells in allergic and non-allergic immune responses: comparison of human and murine data

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838642

7 January 2021

The Syk and ZAP-70 SH2-containing tyrosine kinases are implicated in pre-T cell receptor signaling

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838642

7 January 2021

Mast-cell infiltration of airway smooth muscle in asthma.

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838642

7 January 2021

Increased mast cells and neutrophils in submucosal mucous glands and mucus plugging in patients with asthma

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838642

7 January 2021

Inflammatory cell microlocalisation and airway dysfunction: cause and effect?

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838642

7 January 2021

Sphingosine 1-phosphate modulates human airway smooth muscle cell functions that promote inflammation and airway remodeling in asthma

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838642

7 January 2021

Sphingosine-1-phosphate stimulates contraction of human airway smooth muscle cells

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838642

7 January 2021

Inhalation of sphingosine kinase inhibitor attenuates airway inflammation in asthmatic mouse model

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838642

7 January 2021

Identifiers

DOI

10.1002/EJI.200838642

1 reference

19 August 2017

1 reference

PubMed ID

18924207