Phosphodiesterase 5 inhibition blocks pressure overload-induced cardiac hypertrophy independent of the calcineurin pathway (Q37291307)

19 August 2017

Phosphodiesterase 5 inhibition blocks pressure overload-induced cardiac hypertrophy independent of the calcineurin pathway (English)

1 reference

19 August 2017

Jeffery D Molkentin

8

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author name string

Steven Hsu

1

1 reference

19 August 2017

Takahiro Nagayama

2

1 reference

19 August 2017

Norimichi Koitabashi

3

1 reference

19 August 2017

Manling Zhang

4

1 reference

19 August 2017

Liye Zhou

5

1 reference

19 August 2017

Djahida Bedja

6

1 reference

19 August 2017

Kathleen L Gabrielson

7

1 reference

19 August 2017

David A Kass

9

1 reference

19 August 2017

Eiki Takimoto

10

1 reference

19 August 2017

language of work or name

1 reference

24 November 2008

1 reference

19 August 2017

Cardiovascular Research

1 reference

19 August 2017

81

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19 August 2017

2

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19 August 2017

301-309

1 reference

describes a project that uses

19 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2721646/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Sildenafil stops progressive chamber, cellular, and molecular remodeling and improves calcium handling and function in hearts with pre-existing advanced hypertrophy caused by pressure overload

1 reference

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Measurement of cardiac function using pressure-volume conductance catheter technique in mice and rats

6 September 2017

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Regulator of G-protein signaling subtype 4 mediates antihypertrophic effect of locally secreted natriuretic peptides in the heart

6 September 2017

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Left ventricular hypertrophy and clinical outcomes in hypertensive patients

6 September 2017

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Regulation of G protein-coupled receptor signalling: focus on the cardiovascular system and regulator of G protein signalling proteins

6 September 2017

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Sildenafil: a review of its use in pulmonary arterial hypertension

6 September 2017

1 reference

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Small-molecule therapies for cardiac hypertrophy: moving beneath the cell surface

6 September 2017

1 reference

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Phosphodiesterase regulation of nitric oxide signaling

6 September 2017

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Derepression of pathological cardiac genes by members of the CaM kinase superfamily

6 September 2017

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Role of Ca2+/calmodulin-dependent protein kinase (CaMK) in excitation-contraction coupling in the heart

6 September 2017

1 reference

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Regulation of cardiac hypertrophy by intracellular signalling pathways

6 September 2017

1 reference

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Sildenafil citrate (Viagra) treatment for erectile dysfunction: An updated profile of response and effectiveness

6 September 2017

1 reference

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CaM kinase II selectively signals to histone deacetylase 4 during cardiomyocyte hypertrophy

6 September 2017

1 reference

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Sildenafil, a PDE5 inhibitor, in the treatment of pulmonary hypertension

6 September 2017

1 reference

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Decreased perivascular fibrosis but not cardiac hypertrophy in ROCK1+/- haploinsufficient mice

6 September 2017

1 reference

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Direct and indirect interactions between calcineurin-NFAT and MEK1-extracellular signal-regulated kinase 1/2 signaling pathways regulate cardiac gene expression and cellular growth

6 September 2017

1 reference

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Mice lacking calsarcin-1 are sensitized to calcineurin signaling and show accelerated cardiomyopathy in response to pathological biomechanical stress

6 September 2017

1 reference

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Calcineurin/NFAT coupling participates in pathological, but not physiological, cardiac hypertrophy

6 September 2017

1 reference

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Control of cardiac growth and function by calcineurin signaling

6 September 2017

1 reference

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Therapeutic potential of phosphodiesterase 5 inhibition for cardiovascular disease

6 September 2017

1 reference

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Cardiac hypertrophy: the good, the bad, and the ugly

6 September 2017

1 reference

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Dual roles of modulatory calcineurin-interacting protein 1 in cardiac hypertrophy

6 September 2017

1 reference

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Functional coupling of calcineurin and protein kinase A in mouse ventricular myocytes.

6 September 2017

1 reference

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Inhibition of calcineurin-NFAT hypertrophy signaling by cGMP-dependent protein kinase type I in cardiac myocytes

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2721646

Calcineurin and hypertrophic heart disease: novel insights and remaining questions

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2721646

Impaired cardiac hypertrophic response in Calcineurin Abeta -deficient mice

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2721646

Activated glycogen synthase-3 beta suppresses cardiac hypertrophy in vivo

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2721646

Myocyte-enriched calcineurin-interacting protein, MCIP1, inhibits cardiac hypertrophy in vivo

6 September 2017

1 reference

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cGMP-dependent protein kinase phosphorylates and inactivates RhoA.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2721646

Calsarcins, a novel family of sarcomeric calcineurin-binding proteins

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2721646

Cyclic GMP-dependent protein kinase signaling pathway inhibits RhoA-induced Ca2+ sensitization of contraction in vascular smooth muscle

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2721646

Targeted inhibition of calcineurin prevents agonist-induced cardiomyocyte hypertrophy

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2721646

A calcineurin-dependent transcriptional pathway for cardiac hypertrophy

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2721646

Atrogin-1/muscle atrophy F-box inhibits calcineurin-dependent cardiac hypertrophy by participating in an SCF ubiquitin ligase complex

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2721646

Pressure-independent cardiac hypertrophy in mice with cardiomyocyte-restricted inactivation of the atrial natriuretic peptide receptor guanylyl cyclase-A.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2721646

The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2721646

Foxo transcription factors blunt cardiac hypertrophy by inhibiting calcineurin signaling

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2721646

Calcineurin-nuclear factor of activated T cells pathway-dependent cardiac remodeling in mice deficient in guanylyl cyclase A, a receptor for atrial and brain natriuretic peptides

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2721646

The cardiac-specific nuclear delta(B) isoform of Ca2+/calmodulin-dependent protein kinase II induces hypertrophy and dilated cardiomyopathy associated with increased protein phosphatase 2A activity

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2721646

Calcineurin inhibition normalizes beta-adrenergic responsiveness in the spontaneously hypertensive rat.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2721646

Compartmentalization of cardiac beta-adrenergic inotropy modulation by phosphodiesterase type 5.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2721646

Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2721646

cGMP catabolism by phosphodiesterase 5A regulates cardiac adrenergic stimulation by NOS3-dependent mechanism

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2721646

Sildenafil citrate does not affect cardiac contractility in human or dog heart

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2721646

Phenotypic spectrum caused by transgenic overexpression of activated Akt in the heart

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2721646

Isoproterenol activates extracellular signal-regulated protein kinases in cardiomyocytes through calcineurin

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2721646

Calcineurin Promotes Protein Kinase C and c-Jun NH2-terminal Kinase Activation in the Heart

3 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1093%2FCVR%2FCVN324

Tissue distribution of phosphodiesterase families and the effects of sildenafil on tissue cyclic nucleotides, platelet function, and the contractile responses of trabeculae carneae and aortic rings in vitro

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19029137

12 December 2020

inferred from PubMed ID database lookup

Death, Cardiac Dysfunction, and Arrhythmias Are Increased by Calmodulin Kinase II in Calcineurin Cardiomyopathy

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19029137

12 December 2020

inferred from PubMed ID database lookup

Calcineurin promotes protein kinase C and c-Jun NH2-terminal kinase activation in the heart. Cross-talk between cardiac hypertrophic signaling pathways

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19029137

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1093/CVR/CVN324

1 reference

19 August 2017

1 reference

19 August 2017

1 reference