Germline mitochondrial DNA mutations aggravate ageing and can impair brain development (Q37288018)

19 August 2017

Germline mitochondrial DNA mutations aggravate ageing and can impair brain development (English)

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19 August 2017

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11

Nils-Göran Larsson

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19 August 2017

7

Christoph Freyer

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19 August 2017

4

Stefan Brené

1 reference

19 August 2017

5

Arnaud Mourier

1 reference

19 August 2017

Jaime M Ross

1

1 reference

19 August 2017

James B Stewart

2

1 reference

19 August 2017

Erik Hagström

3

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19 August 2017

Giuseppe Coppotelli

6

1 reference

19 August 2017

Marie Lagouge

8

1 reference

19 August 2017

Barry J Hoffer

9

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19 August 2017

Lars Olson

10

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19 August 2017

language of work or name

English

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publication date

21 August 2013

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19 August 2017

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19 August 2017

501

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19 August 2017

7467

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19 August 2017

412-415

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https://scigraph.springernature.com/pub.10.1038/nature12474

19 August 2017

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cites work

Comparison of mitochondrial mutation spectra in ageing human colonic epithelium and disease: absence of evidence for purifying selection in somatic mitochondrial DNA point mutations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820420

Universal heteroplasmy of human mitochondrial DNA.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820420

Variation in germline mtDNA heteroplasmy is determined prenatally but modified during subsequent transmission

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820420

Mitochondrial aging is accelerated by anti-retroviral therapy through the clonal expansion of mtDNA mutations

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820420

Accumulating mitochondrial DNA mutations drive premature hematopoietic aging phenotypes distinct from physiological stem cell aging

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820420

Ultra-deep sequencing of mouse mitochondrial DNA: mutational patterns and their origins

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820420

High brain lactate is a hallmark of aging and caused by a shift in the lactate dehydrogenase A/B ratio

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820420

Somatic mitochondrial DNA mutations in mammalian aging

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820420

Erythroid dysplasia, megaloblastic anemia, and impaired lymphopoiesis arising from mitochondrial dysfunction

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820420

Mitochondrial DNA mutations and ageing

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820420

A mouse model of mitochondrial disease reveals germline selection against severe mtDNA mutations

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820420

Strong purifying selection in transmission of mammalian mitochondrial DNA

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820420

ON THE NATURE OF THE AGING PROCESS

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820420

Single-molecule PCR: an artifact-free PCR approach for the analysis of somatic mutations

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820420

Mitochondrial DNA and human evolution.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820420

Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820420

Mitochondrial DNA polymerase gamma is essential for mammalian embryogenesis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820420

Understanding the odd science of aging

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820420

Premature ageing in mice expressing defective mitochondrial DNA polymerase

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820420

Mitochondrial DNA mutations in human colonic crypt stem cells

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820420

Cytochrome-c-oxidase deficient cardiomyocytes in the human heart--an age-related phenomenon. A histochemical ultracytochemical study.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820420

Detection of a specific mitochondrial DNA deletion in tissues of older humans

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820420

Mitochondrial role in cell aging

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820420

In vivo mutagenesis reveals that OriL is essential for mitochondrial DNA replication

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820420

Quantification of mitochondrial DNA mutation load

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820420

Studies of sequence heterogeneity of mitochondrial DNA from rat and mouse tissues: evidence for an increased frequency of deletions/additions with aging.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820420

Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820420

Detecting heteroplasmy from high-throughput sequencing of complete human mitochondrial DNA genomes

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820420

A Standard Reference Material to determine the sensitivity of techniques for detecting low-frequency mutations, SNPs, and heteroplasmies in mitochondrial DNA.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820420

Mitochondria and germ-cell death

3 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNATURE12474

Purifying selection of mtDNA and its implications for understanding evolution and mitochondrial disease

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23965628

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

A component promoting oxidative phosphorylation, released from mitochondria during aging

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23965628

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Somatic Progenitor Cell Vulnerability to Mitochondrial DNA Mutagenesis Underlies Progeroid Phenotypes in Polg Mutator Mice

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23965628

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NATURE12474

1 reference

Dimensions Publication ID

19 August 2017

0 references

1 reference

19 August 2017

1 reference