X-linked lymphoproliferative disease (XLP): a model of impaired anti-viral, anti-tumor and humoral immune responses (Q37278914)

19 August 2017

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title

X-linked lymphoproliferative disease (XLP): a model of impaired anti-viral, anti-tumor and humoral immune responses (English)

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19 August 2017

Hamid Bassiri

1

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19 August 2017

W C Janice Yeo

2

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19 August 2017

Jennifer Rothman

3

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19 August 2017

Gary A Koretzky

4

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19 August 2017

Kim E Nichols

5

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19 August 2017

language of work or name

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1 January 2008

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19 August 2017

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19 August 2017

42

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19 August 2017

1-3

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19 August 2017

145-159

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https://scigraph.springernature.com/pub.10.1007/s12026-008-8048-7

19 August 2017

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cites work

Ly9 (CD229)-deficient mice exhibit T cell defects yet do not share several phenotypic characteristics associated with SLAM- and SAP-deficient mice.

1 reference

https://api.crossref.org/works/10.1007%2FS12026-008-8048-7

Cutting edge: the SLAM family receptor Ly108 controls T cell and neutrophil functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-008-8048-7

CD48 stimulation by 2B4 (CD244)-expressing targets activates human NK cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-008-8048-7

Functional requirement for SAP in 2B4-mediated activation of human natural killer cells as revealed by the X-linked lymphoproliferative syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-008-8048-7

Dynamic redistribution of the activating 2B4/SAP complex at the cytotoxic NK cell immune synapse

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-008-8048-7

X-linked lymphoproliferative disease: twenty-five years after the discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-008-8048-7

Impaired humoral immunity in X-linked lymphoproliferative disease is associated with defective IL-10 production by CD4+ T cells

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12026-008-8048-7

SAP is required for Th cell function and for immunity to influenza.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12026-008-8048-7

Differential requirement for the SAP-Fyn interaction during NK T cell development and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-008-8048-7

Restoration of NK T cell development in fyn-mutant mice by a TCR reveals a requirement for Fyn during early NK T cell ontogeny

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-008-8048-7

CD1d1-dependent control of the magnitude of an acute antiviral immune response.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-008-8048-7

Cutting Edge: Defective NK Cell Activation in X-Linked Lymphoproliferative Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-008-8048-7

Cutting Edge: Signaling Lymphocytic Activation Molecule-Associated Protein Controls NKT Cell Functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-008-8048-7

CD1d-restricted help to B cells by human invariant natural killer T lymphocytes

21 January 2018

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12 December 2020

SAP expression in T cells, not in B cells, is required for humoral immunity

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12 December 2020

Potential pathways for regulation of NK and T cell responses: differential X-linked lymphoproliferative syndrome gene product SAP interactions with SLAM and 2B4.

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12 December 2020

Regulation of NKT cell development by SAP, the protein defective in XLP

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12 December 2020

SAP increases FynT kinase activity and is required for phosphorylation of SLAM and Ly9.

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12 December 2020

Manifestations of X-linked lymphoproliferative disease without prior Epstein-Barr exposure

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12 December 2020

Biology and pathogenesis of lymphocytic choriomeningitis virus infection.

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12 December 2020

Expression of the Blast-1 activation/adhesion molecule and its identification as CD48

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12 December 2020

Molecular and cellular pathogenesis of X-linked lymphoproliferative disease

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12 December 2020

2B4-mediated activation of human natural killer cells

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12 December 2020

Identification and characterization of two related murine genes, Eat2a and Eat2b, encoding single SH2-domain adapters

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12 December 2020

Cellular responses to viral infection in humans: lessons from Epstein-Barr virus.

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12 December 2020

Regulation of cellular and humoral immune responses by the SLAM and SAP families of molecules.

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12 December 2020

Negative regulation of natural killer cell function by EAT-2, a SAP-related adaptor

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12 December 2020

Defective B cell responses in the absence of SH2D1A

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12 December 2020

SAP regulates T cell-mediated help for humoral immunity by a mechanism distinct from cytokine regulation

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12 December 2020

Limbic encephalitis as presentation of a SAP deficiency.

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12 December 2020

Molecular basis for positive and negative signaling by the natural killer cell receptor 2B4 (CD244).

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12 December 2020

NK cell regulation by SLAM family receptors and SAP-related adapters

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12 December 2020

Control of T lymphocyte signaling by Ly108, a signaling lymphocytic activation molecule family receptor implicated in autoimmunity

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12 December 2020

Defective NKT cell development in mice and humans lacking the adapter SAP, the X-linked lymphoproliferative syndrome gene product

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12 December 2020

Selective loss of natural killer T cells by apoptosis following infection with lymphocytic choriomeningitis virus.

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12 December 2020

Characterization of SH2D1A missense mutations identified in X-linked lymphoproliferative disease patients

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12 December 2020

EAT-2 is a novel SH2 domain containing protein that is up regulated by Ewing's sarcoma EWS/FLI1 fusion gene

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12 December 2020

Defective NK cell activation in X-linked lymphoproliferative disease

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12 December 2020

X-linked lymphoproliferative disease. 2B4 molecules displaying inhibitory rather than activating function are responsible for the inability of natural killer cells to kill Epstein-Barr virus-infected cells

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12 December 2020

Enhancement of anti-tumor activity in vitro and in vivo by CD150 and SAP

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12 December 2020

The SLAM and SAP gene families control innate and adaptive immune responses.

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12 December 2020

The NKT cell system: bridging innate and acquired immunity

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12 December 2020

Homotypic interactions mediated by Slamf1 and Slamf6 receptors control NKT cell lineage development

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12 December 2020

Increased interleukin 4 and immunoglobulin E production in transgenic mice overexpressing NK1 T cells.

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12 December 2020

The cell surface receptor SLAM controls T cell and macrophage functions

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12 December 2020

Distinct interactions of the X-linked lymphoproliferative syndrome gene product SAP with cytoplasmic domains of members of the CD2 receptor family

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12 December 2020

Use of rituximab in conjunction with immunosuppressive chemotherapy as a novel therapy for Epstein Barr virus-associated hemophagocytic lymphohistiocytosis

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12 December 2020

SAP controls the cytolytic activity of CD8+ T cells against EBV-infected cells.

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12 December 2020

Treatment of primary Epstein-Barr virus infection in patients with X-linked lymphoproliferative disease using B-cell-directed therapy

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12 December 2020

Innate immune responses support adaptive immunity: NKT cells induce B cell activation

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12 December 2020

SAP and SLAM expression in anti-CD3 activated lymphocytes correlates with cytotoxic activity.

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12 December 2020

Missense mutations in SH2D1A identified in patients with X-linked lymphoproliferative disease differentially affect the expression and function of SAP

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12 December 2020

Constitutive Cytokine mRNAs Mark Natural Killer (NK) and NK T Cells Poised for Rapid Effector Function

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12 December 2020

Genetic evidence linking SAP, the X-linked lymphoproliferative gene product, to Src-related kinase FynT in T(H)2 cytokine regulation.

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12 December 2020

CD1d-restricted and TCR-mediated activation of valpha14 NKT cells by glycosylceramides

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12 December 2020

Activating interactions in human NK cell recognition: the role of 2B4-CD48

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12 December 2020

SAP controls T cell responses to virus and terminal differentiation of TH2 cells.

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12 December 2020

Epstein-Barr virus infection

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12 December 2020

SH2D1A regulates T-dependent humoral autoimmunity

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12 December 2020

The Src family tyrosine kinase Fyn regulates natural killer T cell development

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12 December 2020

Signaling lymphocytic activation molecule (SLAM) regulates T cellular cytotoxicity.

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12 December 2020

Host response to EBV infection in X-linked lymphoproliferative disease results from mutations in an SH2-domain encoding gene

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12 December 2020

The regulatory role of Valpha14 NKT cells in innate and acquired immune response.

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12 December 2020

Crystal structures of the XLP protein SAP reveal a class of SH2 domains with extended, phosphotyrosine-independent sequence recognition

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12 December 2020

Patients with X-linked lymphoproliferative disease have a defect in 2B4 receptor-mediated NK cell cytotoxicity

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12 December 2020

Selective generation of functional somatically mutated IgM+CD27+, but not Ig isotype-switched, memory B cells in X-linked lymphoproliferative disease

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12 December 2020

Induction of T cell development from hematopoietic progenitor cells by delta-like-1 in vitro.

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12 December 2020

Molecular dissection of 2B4 signaling: implications for signal transduction by SLAM-related receptors

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12 December 2020

SAP regulates T(H)2 differentiation and PKC-theta-mediated activation of NF-kappaB1

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12 December 2020

Binding of SAP SH2 domain to FynT SH3 domain reveals a novel mechanism of receptor signalling in immune regulation

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12 December 2020

Regulation of SLAM-mediated signal transduction by SAP, the X-linked lymphoproliferative gene product

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12 December 2020

Epstein-Barr virus-negative boys with non-Hodgkin lymphoma are mutated in the SH2D1A gene, as are patients with X-linked lymphoproliferative disease (XLP)

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12 December 2020

Inactivating mutations in an SH2 domain-encoding gene in X-linked lymphoproliferative syndrome

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12 December 2020

2B4 (CD244), NTB-A and CRACC (CS1) stimulate cytotoxicity but no proliferation in human NK cells

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12 December 2020

Long-term loss of canonical NKT cells following an acute virus infection

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12 December 2020

SAP is required for generating long-term humoral immunity

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12 December 2020

Correlation of mutations of the SH2D1A gene and epstein-barr virus infection with clinical phenotype and outcome in X-linked lymphoproliferative disease.

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12 December 2020

SAP mediates specific cytotoxic T-cell functions in X-linked lymphoproliferative disease

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12 December 2020

Altered lymphocyte responses and cytokine production in mice deficient in the X-linked lymphoproliferative disease gene SH2D1A/DSHP/SAP

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12 December 2020

The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM

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12 December 2020

SAP couples Fyn to SLAM immune receptors

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12 December 2020

10.1007/S12026-008-8048-7

Identifiers

DOI

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19 August 2017

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