Neuron-glia crosstalk gets serious: role in pain hypersensitivity (Q37265977)

19 August 2017

1 reference

title

Neuron-glia crosstalk gets serious: role in pain hypersensitivity (English)

1 reference

19 August 2017

1 reference

Ke Ren

1

1 reference

PMCID

2735048

19 August 2017

Ronald Dubner

series ordinal

2

1 reference

PMCID

2735048

19 August 2017

language of work or name

English

0 references

publication date

1 October 2008

1 reference

Current Opinion in Anaesthesiology

19 August 2017

1 reference

19 August 2017

21

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19 August 2017

570-579

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19 August 2017

5

1 reference

Microinjection of IL-1β into the trigeminal transition zone produces bilateral NMDA receptor-dependent orofacial hyperalgesia involving descending circuitry

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1 reference

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1 reference

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1 reference

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Low-dose methotrexate reduces peripheral nerve injury-evoked spinal microglial activation and neuropathic pain behavior in rats

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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6 September 2017

1 reference

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Inhibition of spinal microglial cathepsin S for the reversal of neuropathic pain

6 September 2017

1 reference

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Glial-cytokine-neuronal interactions underlying the mechanisms of persistent pain

6 September 2017

1 reference

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6 September 2017

1 reference

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Sciatic nerve ligation-induced proliferation of spinal cord astrocytes is mediated by kappa opioid activation of p38 mitogen-activated protein kinase

6 September 2017

1 reference

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Rapid co-release of interleukin 1beta and caspase 1 in spinal cord inflammation

6 September 2017

1 reference

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BK-induced COX-2 expression via PKC-delta-dependent activation of p42/p44 MAPK and NF-kappaB in astrocytes

6 September 2017

1 reference

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Astrocyte control of synaptic transmission and neurovascular coupling.

6 September 2017

1 reference

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Could chronic pain and spread of pain sensation be induced and maintained by glial activation?

6 September 2017

1 reference

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6 September 2017

1 reference

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6 September 2017

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The tetrapartite synapse: path to CNS sensitization and chronic pain

6 September 2017

1 reference

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BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain

6 September 2017

1 reference

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6 September 2017

1 reference

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A role for proinflammatory cytokines and fractalkine in analgesia, tolerance, and subsequent pain facilitation induced by chronic intrathecal morphine

6 September 2017

1 reference

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Neurone-to-astrocyte signalling in the brain represents a distinct multifunctional unit.

6 September 2017

1 reference

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6 September 2017

1 reference

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P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury

6 September 2017

1 reference

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6 September 2017

1 reference

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Interleukin-1beta-mediated induction of Cox-2 in the CNS contributes to inflammatory pain hypersensitivity

6 September 2017

1 reference

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Glutamate-mediated astrocyte-neuron signalling

6 September 2017

1 reference

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Role of the CX3CR1/p38 MAPK pathway in spinal microglia for the development of neuropathic pain following nerve injury-induced cleavage of fractalkine

6 September 2017

1 reference

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1 reference

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14 September 2017

1 reference

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Endotoxin-induced appearance of immunoreactive interleukin-1 beta in ramified microglia in rat brain: a light and electron microscopic study

14 September 2017

1 reference

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Stereological and somatotopic analysis of the spinal microglial response to peripheral nerve injury

14 September 2017

1 reference

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Nitric oxide (NO) and nociceptive processing in the spinal cord

28 September 2017

1 reference

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Receptors for neurotransmitters on astrocytes in the mammalian central nervous system

28 September 2017

1 reference

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A peptide c-Jun N-terminal kinase (JNK) inhibitor blocks mechanical allodynia after spinal nerve ligation: respective roles of JNK activation in primary sensory neurons and spinal astrocytes for neuropathic pain development and maintenance.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735048

Quantitative real-time RT-PCR assessment of spinal microglial and astrocytic activation markers in a rat model of neuropathic pain.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735048

Altered expression and uptake activity of spinal glutamate transporters after nerve injury contribute to the pathogenesis of neuropathic pain in rats.

26 June 2018

1 reference

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Role of Na(+)-Ca2+ exchanger in agonist-induced Ca2+ signaling in cultured rat astrocytes

26 June 2018

1 reference

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ATP release from dorsal spinal cord synaptosomes: characterization and neuronal origin.

26 June 2018

1 reference

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Substance P stimulates IL-1 production by astrocytes via intracellular calcium

26 June 2018

1 reference

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P2Y12 receptor upregulation in activated microglia is a gateway of p38 signaling and neuropathic pain

26 June 2018

1 reference

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Evolution of the inflammatory response in the brain following intracerebral hemorrhage and effects of delayed minocycline treatment.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735048

CNS-irrelevant T-cells enter the brain, cause blood-brain barrier disruption but no glial pathology.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735048

Astrocytes potentiate transmitter release at single hippocampal synapses.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735048

IL-1ra alleviates inflammatory hyperalgesia through preventing phosphorylation of NMDA receptor NR-1 subunit in rats

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735048

Complement induction in spinal cord microglia results in anaphylatoxin C5a-mediated pain hypersensitivity.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735048

Nerve conduction blockade in the sciatic nerve prevents but does not reverse the activation of p38 mitogen-activated protein kinase in spinal microglia in the rat spared nerve injury model.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735048

Synaptic islands defined by the territory of a single astrocyte.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735048

Quantification of the rat spinal microglial response to peripheral nerve injury as revealed by immunohistochemical image analysis and flow cytometry

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735048

Chronic intrathecal infusion of minocycline prevents the development of spinal-nerve ligation-induced pain in rats.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735048

Selective stimulation of astrocyte calcium in situ does not affect neuronal excitatory synaptic activity.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735048

Gene transfer to interfere with TNFalpha signaling in neuropathic pain

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735048

Long-term potentiation of neuronal excitation by neuron-glia interactions in the rat spinal dorsal horn.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735048

Glutamate exocytosis from astrocytes controls synaptic strength.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735048

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735048

New evidence for the involvement of spinal fractalkine receptor in pain facilitation and spinal glial activation in rat model of monoarthritis.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735048

Spinal microglia and neuropathic pain in young rats.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735048

Efficacy of propentofylline, a glial modulating agent, on existing mechanical allodynia following peripheral nerve injury.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735048

Induction of astrocyte differentiation by propentofylline increases glutamate transporter expression in vitro: heterogeneity of the quiescent phenotype.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735048

Spinal nerve lesion alters blood-spinal cord barrier function and activates astrocytes in the rat.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735048

NMDA receptors mediate neuron-to-glia signaling in mouse cortical astrocytes.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735048

Inhibition of glutamate uptake in the spinal cord induces hyperalgesia and increased responses of spinal dorsal horn neurons to peripheral afferent stimulation.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735048

Involvement of spinal glia in tetanically sciatic stimulation-induced bilateral mechanical allodynia in rats.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735048

An initial investigation of spinal mechanisms underlying pain enhancement induced by fractalkine, a neuronally released chemokine.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735048

Stress-induced elevation of glucocorticoids increases microglia proliferation through NMDA receptor activation.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735048

Spinal glutamate uptake is critical for maintaining normal sensory transmission in rat spinal cord

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735048

Spinal p38beta isoform mediates tissue injury-induced hyperalgesia and spinal sensitization

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735048

Interleukin-1beta enhances NMDA receptor-mediated current but inhibits excitatory synaptic transmission

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735048

Evidence that exogenous and endogenous fractalkine can induce spinal nociceptive facilitation in rats.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735048

Spinal gap junctions: potential involvement in pain facilitation

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735048

The ultrastructural localisation of the N-methyl-D-aspartate NR2B receptor subunit in rat lumbar spinal cord

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735048

Expression of central glucocorticoid receptors after peripheral nerve injury contributes to neuropathic pain behaviors in rats.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735048

Fractalkine (CX3CL1) and fractalkine receptor (CX3CR1) distribution in spinal cord and dorsal root ganglia under basal and neuropathic pain conditions

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735048

HIV-1 gp120 stimulates proinflammatory cytokine-mediated pain facilitation via activation of nitric oxide synthase-I (nNOS).

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735048

Complete Freunds adjuvant-induced peripheral inflammation evokes glial activation and proinflammatory cytokine expression in the CNS.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735048

Interleukin-1β Enhances NMDA Receptor-Mediated Intracellular Calcium Increase through Activation of the Src Family of Kinases

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735048

Superficial NK1-expressing neurons control spinal excitability through activation of descending pathways

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735048

Microdomains for neuron-glia interaction: parallel fiber signaling to Bergmann glial cells.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735048

Primary astroglial cultures derived from several rat brain regions differentially express mu, delta and kappa opioid receptor mRNA.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735048

Expression of CCR2 in Both Resident and Bone Marrow-Derived Microglia Plays a Critical Role in Neuropathic Pain

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735048

Glutamate-stimulated ATP release from spinal cord astrocytes is potentiated by substance P

3 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735048

Spatial and temporal relationship between monocyte chemoattractant protein-1 expression and spinal glial activation following peripheral nerve injury

3 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735048

ERK is sequentially activated in neurons, microglia, and astrocytes by spinal nerve ligation and contributes to mechanical allodynia in this neuropathic pain model

3 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735048

Signal transduction pathways for epidermal growth factor stimulated cyclooxygenase-2 induction in astrocytes

3 December 2018

1 reference

12 December 2020

GFAP Expression in Lumbar Spinal Cord of Naive and Neuropathic Rats Treated with MK-801

1 reference

12 December 2020

Lentiviral-mediated targeted NF-kappaB blockade in dorsal spinal cord glia attenuates sciatic nerve injury-induced neuropathic pain in the rat

1 reference

12 December 2020

Role of astrocytic S100beta in behavioral hypersensitivity in rodent models of neuropathic pain

1 reference

12 December 2020

Extra-territorial pain in rats with a peripheral mononeuropathy: mechano-hyperalgesia and mechano-allodynia in the territory of an uninjured nerve

1 reference

12 December 2020

Microglial activation in different models of peripheral nerve injury of the rat

1 reference

12 December 2020

Mice overexpressing chemokine ligand 2 (CCL2) in astrocytes display enhanced nociceptive responses

1 reference

12 December 2020

Preprotachykinin-A and substance P receptor (NK1) gene expression in rat astrocytes in vitro

1 reference

12 December 2020

Genetic impairment of interleukin-1 signaling attenuates neuropathic pain, autotomy, and spontaneous ectopic neuronal activity, following nerve injury in mice

1 reference

12 December 2020

Induction of CX3CL1 expression in astrocytes and CX3CR1 in microglia in the spinal cord of a rat model of neuropathic pain

1 reference

12 December 2020

Spinal glial activation in a new rat model of bone cancer pain produced by prostate cancer cell inoculation of the tibia

1 reference

12 December 2020

Direct evidence for spinal cord microglia in the development of a neuropathic pain-like state in mice

1 reference

12 December 2020

Tissue type plasminogen activator induced in rat dorsal horn astrocytes contributes to mechanical hypersensitivity following dorsal root injury

1 reference

12 December 2020

Intrathecal interleukin-1 receptor antagonist in combination with soluble tumor necrosis factor receptor exhibits an anti-allodynic action in a rat model of neuropathic pain

1 reference

12 December 2020

Fractalkine and minocycline alter neuronal activity in the spinal cord dorsal horn

1 reference

12 December 2020

Transgenic glial nuclear factor-kappa B inhibition decreases formalin pain in mice

1 reference

12 December 2020

Extracellular signal-regulated kinase-regulated microglia-neuron signaling by prostaglandin E2 contributes to pain after spinal cord injury

1 reference

12 December 2020

Interleukin-6 is a candidate molecule that transmits inflammatory information to the CNS

1 reference

12 December 2020

Astroglial glutamate-glutamine shuttle is involved in central sensitization of nociceptive neurons in rat medullary dorsal horn

1 reference

12 December 2020

Intrathecal administration of ATP produces long-lasting allodynia in rats: Differential mechanisms in the phase of the induction and maintenance

1 reference

12 December 2020

A critical role of toll-like receptor 2 in nerve injury-induced spinal cord glial cell activation and pain hypersensitivity

1 reference

12 December 2020

AMPA-kainate subtypes of glutamate receptor in rat cerebral microglia

1 reference

12 December 2020

Glutamate-, kainate- and NMDA-evoked membrane currents in identified glial cells in rat spinal cord slice

1 reference

12 December 2020

Minocycline and pentoxifylline attenuate allodynia and hyperalgesia and potentiate the effects of morphine in rat and mouse models of neuropathic pain

1 reference

12 December 2020

10.1097/ACO.0B013E32830EDBDF

Identifiers

DOI

1 reference

19 August 2017

1 reference

19 August 2017

1 reference

PMCID

2735048