5-Lipoxygenase gene disruption reduces amyloid-beta pathology in a mouse model of Alzheimer's disease (Q37232572)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17998412%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

title

5-Lipoxygenase gene disruption reduces amyloid-beta pathology in a mouse model of Alzheimer's disease (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17998412%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

0 references

0 references

1

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10 January 2020

Thomas Wisniewski

4

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10 January 2020

author name string

Jiamin Zhuo

2

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10 January 2020

Cinzia M Chinnici

3

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10 January 2020

Domenico Praticò

5

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10 January 2020

language of work or name

English

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publication date

12 November 2007

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10 January 2020

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10 January 2020

volume

22

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10 January 2020

page(s)

1169-1178

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10 January 2020

issue

4

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Inflammation in Alzheimer disease: driving force, bystander or beneficial response?

10 January 2020

cites work

1 reference

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Coxibs and Alzheimer's disease: should they stay or should they go?

6 September 2017

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Abeta42 is essential for parenchymal and vascular amyloid deposition in mice

6 September 2017

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Diverse compounds mimic Alzheimer disease-causing mutations by augmenting Abeta42 production

6 September 2017

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Modulation of nuclear factor-kappa B activity by indomethacin influences A beta levels but not A beta precursor protein metabolism in a model of Alzheimer's disease

6 September 2017

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12/15-lipoxygenase is increased in Alzheimer's disease: possible involvement in brain oxidative stress

6 September 2017

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NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivo

6 September 2017

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Alzheimer disease therapy: can the amyloid cascade be halted?

6 September 2017

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Deciphering the genesis and fate of amyloid beta-protein yields novel therapies for Alzheimer disease

6 September 2017

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Prostaglandins and leukotrienes: advances in eicosanoid biology

6 September 2017

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Aging-associated up-regulation of neuronal 5-lipoxygenase expression: putative role in neuronal vulnerability

6 September 2017

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Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

6 September 2017

1 reference

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Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology

6 September 2017

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Eicosanoids in synaptic transmission

6 September 2017

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Leukotrienes and the brain.

28 September 2017

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An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.

26 June 2018

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Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43).

26 June 2018

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The 5-lipoxygenase enzymatic pathway in the mouse brain: young versus old.

26 June 2018

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Spatio-temporal properties of 5-lipoxygenase expression and activation in the brain after focal cerebral ischemia in rats.

3 September 2018

1 reference

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DAPT-induced intracellular accumulations of longer amyloid beta-proteins: further implications for the mechanism of intramembrane cleavage by gamma-secretase.

3 September 2018

1 reference

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Deletion of the prostaglandin E2 EP2 receptor reduces oxidative damage and amyloid burden in a model of Alzheimer's disease.

3 September 2018

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Elevation of 12/15 lipoxygenase products in AD and mild cognitive impairment

3 September 2018

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Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death.

3 September 2018

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Early vitamin E supplementation in young but not aged mice reduces Abeta levels and amyloid deposition in a transgenic model of Alzheimer's disease.

3 September 2018

1 reference

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Early upregulation of hippocampal 5-lipoxygenase following systemic administration of kainate to rats.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2698428

Cell type-dependent activation of 5-lipoxygenase by arachidonic acid

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2698428

Repetitive mild brain trauma accelerates Abeta deposition, lipid peroxidation, and cognitive impairment in a transgenic mouse model of Alzheimer amyloidosis.

3 September 2018

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A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity

3 September 2018

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5-Lipoxygenase (5-LOX) promoter polymorphism in patients with early-onset and late-onset Alzheimer's disease

3 September 2018

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Increased lipid peroxidation precedes amyloid plaque formation in an animal model of Alzheimer amyloidosis.

3 September 2018

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Increased F2-isoprostanes in Alzheimer's disease: evidence for enhanced lipid peroxidation in vivo.

3 September 2018

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Role of leukotrienes revealed by targeted disruption of the 5-lipoxygenase gene.

3 September 2018

1 reference

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Cysteinyl-leukotriene production during limbic seizures triggered by kainic acid.

3 September 2018

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Pharmacogenetic association between ALOX5 promoter genotype and the response to anti-asthma treatment

3 September 2018

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12 December 2020

Arachidonate 5-lipoxygenase and its activating protein: prominent hippocampal expression and role in somatostatin signaling

1 reference

12 December 2020

Downregulation of neuronal cyclooxygenase-2 expression in end stage Alzheimer's disease

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12 December 2020

Inflammatory 5-LOX mRNA and protein are increased in brain of aging rats

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12 December 2020

Identifiers

DOI

10.1096/FJ.07-9131.COM

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17998412%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17998412%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

1 reference