A central role for free heme in the pathogenesis of severe malaria: the missing link? (Q37222297)

19 August 2017

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title

A central role for free heme in the pathogenesis of severe malaria: the missing link? (English)

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19 August 2017

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Viktória Jeney

3

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Ana Ferreira

object named as

Ana Ferreira

1

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József Balla

object named as

József Balla

2

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Miguel P. Soares

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Miguel P Soares

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author name string

György Balla

4

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19 August 2017

19 July 2008

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Journal of Molecular Medicine

19 August 2017

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19 August 2017

86

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19 August 2017

1097-1111

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19 August 2017

10

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https://scigraph.springernature.com/pub.10.1007/s00109-008-0368-5

19 August 2017

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cites work

Heme inhibits human neutrophil apoptosis: involvement of phosphoinositide 3-kinase, MAPK, and NF-kappaB.

1 reference

https://api.crossref.org/works/10.1007%2FS00109-008-0368-5

New insights into biliverdin reductase functions: linking heme metabolism to cell signaling

21 January 2018

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Carbon monoxide generated by heme oxygenase-1 suppresses the rejection of mouse-to-rat cardiac transplants

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00109-008-0368-5

The antiapoptotic effect of heme oxygenase-1 in endothelial cells involves the degradation of p38 alpha MAPK isoform.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00109-008-0368-5

Heat shock protein-70 mediates the cytoprotective effect of carbon monoxide: involvement of p38 beta MAPK and heat shock factor-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-008-0368-5

Blood-brain barrier function in cerebral malaria and CNS infections in Vietnam

21 January 2018

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The silent path to thousands of merozoites: the Plasmodium liver stage

21 January 2018

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12 December 2020

Host temperature and control of 24-hour and 48-hour cycles in malaria parasites

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12 December 2020

Heme binding to albuminoid proteins is the result of recent evolution

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12 December 2020

The haptoglobin 2-2 genotype is associated with a reduced incidence of Plasmodium falciparum malaria in children on the coast of Kenya

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12 December 2020

Inhibition by chloroquine of a novel haem polymerase enzyme activity in malaria trophozoites

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12 December 2020

Low nitric oxide bioavailability contributes to the genesis of experimental cerebral malaria.

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12 December 2020

Carbon monoxide suppresses arteriosclerotic lesions associated with chronic graft rejection and with balloon injury

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12 December 2020

CO as a cellular signaling molecule

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12 December 2020

Crystal structure of hemopexin reveals a novel high-affinity heme site formed between two beta-propeller domains

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12 December 2020

Heme oxygenase-1 and carbon monoxide suppress the pathogenesis of experimental cerebral malaria.

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12 December 2020

PPARgamma and PPARdelta negatively regulate specific subsets of lipopolysaccharide and IFN-gamma target genes in macrophages

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12 December 2020

Immunological processes in malaria pathogenesis.

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12 December 2020

Ferriporphyrins and endothelium: a 2-edged sword-promotion of oxidation and induction of cytoprotectants

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Hydrophobicity: an ancient damage-associated molecular pattern that initiates innate immune responses.

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12 December 2020

Malaria, cause of ahaptoglobinaemia in Africans.

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12 December 2020

Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease

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12 December 2020

Heme oxygenase and carbon monoxide initiate homeostatic signaling

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12 December 2020

Disentangling genetic variation for resistance and tolerance to infectious diseases in animals

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12 December 2020

Heme oxygenase-1 and carbon monoxide suppress autoimmune neuroinflammation

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12 December 2020

Bilirubin: a natural inhibitor of vascular smooth muscle cell proliferation

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12 December 2020

Elevated levels of methaemoglobin in Tanzanian children with severe and uncomplicated malaria

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12 December 2020

Common polymorphisms of toll-like receptors 4 and 9 are associated with the clinical manifestation of malaria during pregnancy

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12 December 2020

The p38 signal transduction pathway: activation and function

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12 December 2020

Spectral and ligand-binding properties of an unusual hemoprotein, the ferric form of soluble guanylate cyclase

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12 December 2020

Hemoglobin binding with haptoglobin: delineation of the haptoglobin binding site on the alpha-chain of human hemoglobin

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12 December 2020

Hemoglobin metabolism in the malaria parasite Plasmodium falciparum

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12 December 2020

The enzymatic conversion of heme to bilirubin by microsomal heme oxygenase

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12 December 2020

Basis of guanylate cyclase activation by carbon monoxide

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12 December 2020

Protozoan encounters with Toll-like receptor signalling pathways: implications for host parasitism.

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12 December 2020

The role of heme oxygenase-1 promoter polymorphisms in human disease

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12 December 2020

Binding of Hæmatin by Human Serum Albumin

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12 December 2020

The pathogenic basis of malaria

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12 December 2020

Malaria hemozoin is immunologically inert but radically enhances innate responses by presenting malaria DNA to Toll-like receptor 9.

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Indicators of life-threatening malaria in African children

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12 December 2020

Identification of the haemoglobin scavenger receptor.

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12 December 2020

Heme oxygenase-1 in lesions of human cerebral malaria.

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12 December 2020

Induction of experimental cerebral malaria is independent of TLR2/4/9.

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12 December 2020

Mitogenic and co-mitogenic properties of hemin

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12 December 2020

Carbon monoxide differentially inhibits TLR signaling pathways by regulating ROS-induced trafficking of TLRs to lipid rafts

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12 December 2020

Hemin lyses malaria parasites

1 reference

12 December 2020

Blood mononuclear cell gene expression profiles characterize the oxidant, hemolytic, and inflammatory stress of sickle cell disease

1 reference

12 December 2020

Identification of the receptor scavenging hemopexin-heme complexes.

1 reference

12 December 2020

Immune stimulatory properties of metalloporphyrins.

1 reference

12 December 2020

Pro-oxidant and cytotoxic effects of circulating heme.

1 reference

12 December 2020

The clinical sequelae of intravascular hemolysis and extracellular plasma hemoglobin: a novel mechanism of human disease

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12 December 2020

Duplication within the haptoglobin Hp2 gene

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12 December 2020

Exchange of heme among hemoglobins and between hemoglobin and albumin

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12 December 2020

Development and regulation of cell-mediated immune responses to the blood stages of malaria: implications for vaccine research

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12 December 2020

Does nitric oxide modulate mitochondrial energy generation and apoptosis?

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12 December 2020

Mechanisms regulating the reactions of human hemoglobin with oxygen and carbon monoxide

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12 December 2020

THE BINDING OF CARBON MONOXIDE BY CYTOCHROME C OXIDASE AND THE RATIO OF THE CYTOCHROMES A AND A3

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12 December 2020

Phagocyte-derived reactive oxygen species do not influence the progression of murine blood-stage malaria infections

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12 December 2020

Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency

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12 December 2020

The ferritins: molecular properties, iron storage function and cellular regulation

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12 December 2020

Carbon monoxide orchestrates a protective response through PPARgamma.

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12 December 2020

Toll-like receptor (TLR) polymorphisms in African children: Common TLR-4 variants predispose to severe malaria

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12 December 2020

Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway

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12 December 2020

Characterization of heme as activator of Toll-like receptor 4.

1 reference

12 December 2020

Overexpression of wild type and mutated human ferritin H-chain in HeLa cells: in vivo role of ferritin ferroxidase activity.

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12 December 2020

Methaemoglobin profile in malaria infected children in Calabar.

1 reference

12 December 2020

Caveolin-1 expression by means of p38beta mitogen-activated protein kinase mediates the antiproliferative effect of carbon monoxide

1 reference

12 December 2020

Hypoxia-inducible factor 1alpha stabilization by carbon monoxide results in cytoprotective preconditioning

1 reference

12 December 2020

Murine cerebral malaria development is independent of toll-like receptor signaling

1 reference

12 December 2020

Ferritin Heavy Chain Upregulation by NF-κB Inhibits TNFα-Induced Apoptosis by Suppressing Reactive Oxygen Species

1 reference

12 December 2020

Pathogenesis, clinical features, and neurological outcome of cerebral malaria

1 reference

12 December 2020

In vivo thiyl free radical formation from hemoglobin following administration of hydroperoxides

1 reference

12 December 2020

Microsatellite polymorphism in the heme oxygenase-1 gene promoter is associated with susceptibility to cerebral malaria in Myanmar.

1 reference

12 December 2020

Heme, heme oxygenase and ferritin in vascular endothelial cell injury

1 reference

12 December 2020

Neutrophil activation by heme: implications for inflammatory processes.

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12 December 2020

Heme oxygenase-1: unleashing the protective properties of heme

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12 December 2020

Impaired nitric oxide bioavailability and L-arginine reversible endothelial dysfunction in adults with falciparum malaria

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12 December 2020

Heme oxygenase-1 is an anti-inflammatory host factor that promotes murine plasmodium liver infection.

1 reference

12 December 2020

A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis

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12 December 2020

Carboxyhemoglobin levels in Kenyan children with Plasmodium falciparum malaria

1 reference

12 December 2020

Ferritin: a cytoprotective antioxidant strategem of endothelium

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12 December 2020

Carbon monoxide generated by heme oxygenase 1 suppresses endothelial cell apoptosis.

1 reference

12 December 2020

Activation of soluble guanylate cyclase by carbon monoxide and nitric oxide: a mechanistic model.

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12 December 2020

Induction of proinflammatory responses in macrophages by the glycosylphosphatidylinositols of Plasmodium falciparum: cell signaling receptors, glycosylphosphatidylinositol (GPI) structural requirement, and regulation of GPI activity

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12 December 2020

Malaria: mechanisms of erythrocytic infection and pathological correlates of severe disease

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12 December 2020

Respiratory protein-generated reactive oxygen species as an antimicrobial strategy.

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12 December 2020

Induction of HO-1 in tissue macrophages and monocytes in fatal falciparum malaria and sepsis

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12 December 2020

Carbon monoxide signals via inhibition of cytochrome c oxidase and generation of mitochondrial reactive oxygen species

1 reference

12 December 2020

Pathological role of Toll-like receptor signaling in cerebral malaria.

1 reference

12 December 2020

Cellular stress and injury responses in the brains of adult Vietnamese patients with fatal Plasmodium falciparum malaria

1 reference

12 December 2020

Bilirubin is an antioxidant of possible physiological importance

1 reference

12 December 2020

Heme Induces Neutrophil Migration and Reactive Oxygen Species Generation through Signaling Pathways Characteristic of Chemotactic Receptors

1 reference

12 December 2020

Endothelial-cell heme uptake from heme proteins: induction of sensitization and desensitization to oxidant damage

1 reference

12 December 2020

Heavy chain ferritin acts as an antiapoptotic gene that protects livers from ischemia reperfusion injury

1 reference

12 December 2020

NPAS2: a gas-responsive transcription factor

1 reference

12 December 2020

The cytokine theory of human cerebral malaria.

1 reference

12 December 2020

Tumor necrosis factor (cachectin) as an essential mediator in murine cerebral malaria

1 reference

12 December 2020

10.1007/S00109-008-0368-5

Identifiers

DOI

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19 August 2017

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PubMed ID

18641963