Acetylation of prostaglandin H2 synthases by aspirin is inhibited by redox cycling of the peroxidase (Q37218687)

19 August 2017

Acetylation of prostaglandin H2 synthases by aspirin is inhibited by redox cycling of the peroxidase (English)

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19 August 2017

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7

John A Oates

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19 August 2017

6

Olivier Boutaud

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19 August 2017

Manju Bala

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19 August 2017

Cindy N Chin

2

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19 August 2017

Asha T Logan

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19 August 2017

Taneem Amin

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19 August 2017

Lawrence J Marnett

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19 August 2017

language of work or name

English

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publication date

27 December 2007

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19 August 2017

Biochemical Pharmacology

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19 August 2017

75

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19 August 2017

7

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1472-1481

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describes a project that uses

19 August 2017

ImageQuant

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2693035/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Role of Tyr348 in Tyr385 radical dynamics and cyclooxygenase inhibitor interactions in prostaglandin H synthase-2

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Targeted lipidomics using electron capture atmospheric pressure chemical ionization mass spectrometry

6 September 2017

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Functional and biochemical evaluation of platelet aspirin resistance after coronary artery bypass surgery

6 September 2017

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Determinants of the cellular specificity of acetaminophen as an inhibitor of prostaglandin H(2) synthases.

6 September 2017

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Structural analysis of NSAID binding by prostaglandin H2 synthase: time-dependent and time-independent inhibitors elicit identical enzyme conformations

6 September 2017

1 reference

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Characterization of the lysyl adducts formed from prostaglandin H2 via the levuglandin pathway

6 September 2017

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The febrile response to lipopolysaccharide is blocked in cyclooxygenase-2(-/-), but not in cyclooxygenase-1(-/-) mice

6 September 2017

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Analysis of hydroperoxide-induced tyrosyl radicals and lipoxygenase activity in aspirin-treated human prostaglandin H synthase-2

6 September 2017

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Endothelial cells of the rat brain vasculature express cyclooxygenase-2 mRNA in response to systemic interleukin-1 beta: a possible site of prostaglandin synthesis responsible for fever

6 September 2017

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Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase

6 September 2017

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Acetylation of human prostaglandin endoperoxide synthase-2 (cyclooxygenase-2) by aspirin

6 September 2017

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The structural basis of aspirin activity inferred from the crystal structure of inactivated prostaglandin H2 synthase

6 September 2017

1 reference

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Selective cumulative inhibition of platelet thromboxane production by low-dose aspirin in healthy subjects

6 September 2017

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Endogenous biosynthesis of prostacyclin and thromboxane and platelet function during chronic administration of aspirin in man

6 September 2017

1 reference

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Pharmacokinetics of aspirin and salicylate in relation to inhibition of arachidonate cyclooxygenase and antiinflammatory activity

6 September 2017

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The mechanism of the effect of aspirin on human platelets. I. Acetylation of a particulate fraction protein

6 September 2017

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Sensitivity of fatty acid cyclooxygenase from human aorta to acetylation by aspirin

6 September 2017

1 reference

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Prostaglandin biosynthesis can be triggered by lipid peroxides

6 September 2017

1 reference

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Sodium salicylate inhibits cyclo-oxygenase-2 activity independently of transcription factor (nuclear factor kappaB) activation: role of arachidonic acid

14 September 2017

1 reference

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Identification of Tyr504 as an alternative tyrosyl radical site in human prostaglandin H synthase-2.

28 September 2017

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Comparison of the peroxidase reaction kinetics of prostaglandin H synthase-1 and -2.

26 June 2018

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Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs.

26 June 2018

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Optical spectra and kinetics of reactions of prostaglandin H synthase: effects of the substrates 13-hydroperoxyoctadeca-9,11-dienoic acid, arachidonic acid, N,N,N',N'-tetramethyl-p-phenylenediamine, and phenol and of the nonsteroidal anti-inflammato

26 June 2018

1 reference

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Tyrosine 385 of prostaglandin endoperoxide synthase is required for cyclooxygenase catalysis

26 June 2018

1 reference

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Inhibition of prostaglandin H2 synthases by salicylate is dependent on the oxidative state of the enzymes.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2693035

High-field EPR study of tyrosyl radicals in prostaglandin H(2) synthase-1.

3 September 2018

1 reference

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Electron microscopic evidence for induction of cyclooxygenase-2 in brain endothelial cells.

3 September 2018

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Comparison of hydroperoxide initiator requirements for the cyclooxygenase activities of prostaglandin H synthase-1 and -2.

3 September 2018

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The binding of arachidonic acid in the cyclooxygenase active site of mouse prostaglandin endoperoxide synthase-2 (COX-2). A putative L-shaped binding conformation utilizing the top channel region

3 September 2018

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12 December 2020

The formation of stable fatty acid substrate complexes in prostaglandin H(2) synthase-1

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12 December 2020

Stimulation and blockade of prostaglandin biosynthesis

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12 December 2020

Isolation and covalent structure of the aspirin-modified, active-site region of prostaglandin synthetase

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12 December 2020

Mechanism of the stimulation of prostaglandin H synthase and prostacyclin synthase by the antithrombotic and antimetastatic agent, nafazatrom

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12 December 2020

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12 December 2020

Higher oxidation states of prostaglandin H synthase. EPR study of a transient tyrosyl radical in the enzyme during the peroxidase reaction

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12 December 2020

Electron spin resonance investigation of tyrosyl radicals of prostaglandin H synthase. Relation to enzyme catalysis

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12 December 2020

Prostaglandin H synthase: perturbation of the tyrosyl radical as a probe of anticyclooxygenase agents

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12 December 2020

The catalytic outcomes of the constitutive and the mitogen inducible isoforms of prostaglandin H2 synthase are markedly affected by glutathione and glutathione peroxidase(s)

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12 December 2020

10.1016/J.BCP.2007.12.005

Identifiers

DOI

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19 August 2017

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19 August 2017

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