Measuring target effect of proposed disease-modifying therapies in Alzheimer's disease (Q37215837)

19 August 2017

1 reference

title

Measuring target effect of proposed disease-modifying therapies in Alzheimer's disease (English)

1 reference

19 August 2017

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Randall J Bateman

1

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William E. Klunk

object named as

William E Klunk

series ordinal

2

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publication date

1 July 2008

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19 August 2017

10

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based on heuristic

inferred from page(s)

published in

Neurotherapeutics

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19 August 2017

5

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19 August 2017

381-390

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19 August 2017

3

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https://scigraph.springernature.com/pub.10.1016/j.nurt.2008.05.009

19 August 2017

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cites work

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6 September 2017

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A Oligomer-Induced Aberrations in Synapse Composition, Shape, and Density Provide a Molecular Basis for Loss of Connectivity in Alzheimer's Disease

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6 September 2017

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A century of Alzheimer's disease

6 September 2017

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APP duplication is sufficient to cause early onset Alzheimer's dementia with cerebral amyloid angiopathy

6 September 2017

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Mice as models: transgenic approaches and Alzheimer's disease.

6 September 2017

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6 September 2017

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6 September 2017

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Mean age-of-onset of familial alzheimer disease caused by presenilin mutations correlates with both increased Abeta42 and decreased Abeta40.

6 September 2017

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CSF amyloid-beta-peptides in Alzheimer's disease, dementia with Lewy bodies and Parkinson's disease dementia

6 September 2017

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Current concepts in therapeutic strategies targeting cognitive decline and disease modification in Alzheimer's disease

6 September 2017

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Neuronal or glial expression of human apolipoprotein e4 affects parenchymal and vascular amyloid pathology differentially in different brain regions of double- and triple-transgenic mice

6 September 2017

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Transgenic models of Alzheimer's disease: learning from animals

6 September 2017

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APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy

6 September 2017

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Persistent amyloidosis following suppression of Abeta production in a transgenic model of Alzheimer disease

6 September 2017

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Molecular, structural, and functional characterization of Alzheimer's disease: evidence for a relationship between default activity, amyloid, and memory

6 September 2017

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Diverse compounds mimic Alzheimer disease-causing mutations by augmenting Abeta42 production

6 September 2017

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Environmental enrichment reduces Abeta levels and amyloid deposition in transgenic mice

6 September 2017

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Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function

6 September 2017

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Dietary factors and Alzheimer's disease

6 September 2017

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Alzheimer disease: mechanistic understanding predicts novel therapies

6 September 2017

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Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B

6 September 2017

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Alzheimer Disease in the US Population

6 September 2017

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NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivo

6 September 2017

1 reference

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Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

6 September 2017

1 reference

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Amyloid-beta binding molecule: potential role in the pathogenesis and treatment of Alzheimer disease.

6 September 2017

1 reference

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Evidence that nonsteroidal anti-inflammatory drugs decrease amyloid beta 42 production by direct modulation of gamma-secretase activity

6 September 2017

1 reference

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Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

6 September 2017

1 reference

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The morphological phenotype of beta-amyloid plaques and associated neuritic changes in Alzheimer's disease

6 September 2017

1 reference

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Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease

6 September 2017

1 reference

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Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2588423

Comparison of neurodegenerative pathology in transgenic mice overexpressing V717F beta-amyloid precursor protein and Alzheimer's disease

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2588423

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2588423

Re-evaluation of the structural organization of neuritic plaques in Alzheimer's disease.

6 September 2017

1 reference

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Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

6 September 2017

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Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

6 September 2017

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Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

6 September 2017

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Senile plaque neurites in Alzheimer disease accumulate amyloid precursor protein

6 September 2017

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Cerebrospinal fluid tau/beta-amyloid(42) ratio as a prediction of cognitive decline in nondemented older adults

6 September 2017

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Association between CSF biomarkers and incipient Alzheimer's disease in patients with mild cognitive impairment: a follow-up study

14 September 2017

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Kinetic modeling of amyloid binding in humans using PET imaging and Pittsburgh Compound-B.

14 September 2017

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In-vivo imaging of Alzheimer disease beta-amyloid with [11C]SB-13 PET.

14 September 2017

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Decreased beta-amyloid1-42 and increased tau levels in cerebrospinal fluid of patients with Alzheimer disease

14 September 2017

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Production of amyloid beta protein from normal amyloid beta-protein precursor (beta APP) and the mutated beta APPS linked to familial Alzheimer's disease

14 September 2017

1 reference

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Molecular imaging with Pittsburgh Compound B confirmed at autopsy: a case report

28 September 2017

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Longitudinal study of cerebrospinal fluid levels of tau, A beta1-40, and A beta1-42(43) in Alzheimer's disease: a study in Japan.

26 June 2018

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Detection of soluble forms of the beta-amyloid precursor protein in human plasma.

26 June 2018

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Imaging of amyloid beta in Alzheimer's disease with 18F-BAY94-9172, a novel PET tracer: proof of mechanism

26 June 2018

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In vitro characterization of Pittsburgh compound-B binding to Lewy bodies.

3 September 2018

1 reference

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Longitudinal changes of CSF biomarkers in memory clinic patients.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2588423

Insensitivity to Abeta42-lowering nonsteroidal anti-inflammatory drugs and gamma-secretase inhibitors is common among aggressive presenilin-1 mutations.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2588423

2-(2-[2-Dimethylaminothiazol-5-yl]ethenyl)-6- (2-[fluoro]ethoxy)benzoxazole: a novel PET agent for in vivo detection of dense amyloid plaques in Alzheimer's disease patients.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2588423

Association of low plasma Abeta42/Abeta40 ratios with increased imminent risk for mild cognitive impairment and Alzheimer disease.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2588423

Fluctuations of CSF amyloid-beta levels: implications for a diagnostic and therapeutic biomarker.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2588423

Small molecule inhibitors of aggregation indicate that amyloid beta oligomerization and fibrillization pathways are independent and distinct

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2588423

PET of brain amyloid and tau in mild cognitive impairment.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2588423

A Phase II study targeting amyloid-beta with 3APS in mild-to-moderate Alzheimer disease.

3 September 2018

1 reference

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Cerebrospinal fluid amyloid beta42/phosphorylated tau ratio discriminates between Alzheimer's disease and vascular dementia.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2588423

Two-year follow-up of amyloid deposition in patients with Alzheimer's disease.

3 September 2018

1 reference

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Effects of a gamma-secretase inhibitor in a randomized study of patients with Alzheimer disease

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2588423

Radioiodinated clioquinol as a biomarker for beta-amyloid: Zn complexes in Alzheimer's disease

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2588423

Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Abeta42 in humans.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2588423

Synaptic activity regulates interstitial fluid amyloid-beta levels in vivo.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2588423

Simplified quantification of Pittsburgh Compound B amyloid imaging PET studies: a comparative analysis

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2588423

Binding of the positron emission tomography tracer Pittsburgh compound-B reflects the amount of amyloid-beta in Alzheimer's disease brain but not in transgenic mouse brain.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2588423

Effects of Abeta immunization (AN1792) on MRI measures of cerebral volume in Alzheimer disease.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2588423

Value of CSF beta-amyloid1-42 and tau as predictors of Alzheimer's disease in patients with mild cognitive impairment.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2588423

Cerebrospinal fluid tau and beta-amyloid: how well do these biomarkers reflect autopsy-confirmed dementia diagnoses?

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2588423

In VivoAssessment of Brain Interstitial Fluid with Microdialysis Reveals Plaque-Associated Changes in Amyloid-β Metabolism and Half-Life

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2588423

Genetic background regulates -amyloid precursor protein processing and -amyloid deposition in the mouse

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2588423

Age but not diagnosis is the main predictor of plasma amyloid beta-protein levels.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2588423

Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2588423

Antibodies against beta-amyloid slow cognitive decline in Alzheimer's disease.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2588423

Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2588423

Plaque-associated disruption of CSF and plasma amyloid-beta (Abeta) equilibrium in a mouse model of Alzheimer's disease.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2588423

Prednisolone (30-60 mg/day) for diseases other than AD decreases amyloid beta-peptides in CSF.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2588423

The selective muscarinic M1 agonist AF102B decreases levels of total Abeta in cerebrospinal fluid of patients with Alzheimer's disease.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2588423

Cerebrospinal fluid beta-amyloid(1-42) in Alzheimer disease: differences between early- and late-onset Alzheimer disease and stability during the course of disease.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2588423

High cerebrospinal fluid tau and low amyloid beta42 levels in the clinical diagnosis of Alzheimer disease and relation to apolipoprotein E genotype.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2588423

[The AAP and PS1/2 mutations linked to early onset familial Alzheimer's disease increase the extracellular concentration and A beta 1-42 (43)].

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2588423

Neuroimaging of vessel amyloid in Alzheimer's disease.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2588423

The E280A presenilin 1 Alzheimer mutation produces increased A beta 42 deposition and severe cerebellar pathology.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2588423

Familial and sporadic Alzheimer's disease: neuropathology cannot exclude a final common pathway.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2588423

Plasma A[beta]40 and A[beta]42 and Alzheimer's disease: relation to age, mortality, and risk

3 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18625449

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Environmental enrichment exacerbates amyloid plaque formation in a transgenic mouse model of Alzheimer disease

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18625449

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.NURT.2008.05.009

1 reference

PMCID

2588423

Dimensions Publication ID

19 August 2017

0 references

1 reference

19 August 2017

1 reference

PMCID

2588423