Statins' immunomodulatory potential against Th17 cell-mediated autoimmune response (Q37165311)

18 August 2017

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title

Statins' immunomodulatory potential against Th17 cell-mediated autoimmune response (English)

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18 August 2017

2

Silva Markovic-Plese

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author name string

Xin Zhang

series ordinal

1

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PubMed ID

18484192

18 August 2017

Silva Markovic-Plese

series ordinal

2

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18 August 2017

1 January 2008

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18 August 2017

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18 August 2017

41

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18 August 2017

3

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18 August 2017

165-174

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https://scigraph.springernature.com/pub.10.1007/s12026-008-8019-z

18 August 2017

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Isoprenoids as mediators of the biological effects of statins

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Inhibition of Rho GTPases with protein prenyltransferase inhibitors prevents leukocyte recruitment to the central nervous system and attenuates clinical signs of disease in an animal model of multiple sclerosis

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Atorvastatin inhibits autoreactive B cell activation and delays lupus development in New Zealand black/white F1 mice

21 January 2018

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A novel anti-inflammatory role for simvastatin in inflammatory arthritis

21 January 2018

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A novel anti-inflammatory role of simvastatin in a murine model of allergic asthma

21 January 2018

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Interleukin-17 mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosis

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A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis.

21 January 2018

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12 December 2020

Statin therapy and autoimmune disease: from protein prenylation to immunomodulation

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12 December 2020

Phenotypic and functional features of human Th17 cells

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12 December 2020

Molecular tracking of antigen-specific T cell clones in neurological immune-mediated disorders

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12 December 2020

SOCS-3 negatively regulates innate and adaptive immune mechanisms in acute IL-1-dependent inflammatory arthritis

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Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells

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12 December 2020

Intracellular protein therapy with SOCS3 inhibits inflammation and apoptosis

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12 December 2020

Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation

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12 December 2020

The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease

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12 December 2020

The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells

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12 December 2020

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

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12 December 2020

TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1.

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12 December 2020

Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system

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12 December 2020

Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells

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12 December 2020

Simvastatin inhibits MMP-9 secretion from human saphenous vein smooth muscle cells by inhibiting the RhoA/ROCK pathway and reducing MMP-9 mRNA levels

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HMG-CoA reductase inhibitors suppress maturation of human dendritic cells: new implications for atherosclerosis

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T-bet regulates the fate of Th1 and Th17 lymphocytes in autoimmunity

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TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties

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Dendritic cells transduced with SOCS-3 exhibit a tolerogenic/DC2 phenotype that directs type 2 Th cell differentiation in vitro and in vivo

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Optimal induction of T helper 17 cells in humans requires T cell receptor ligation in the context of Toll-like receptor-activated monocytes.

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HMG-CoA reductase inhibitor augments survival and differentiation of oligodendrocyte progenitors in animal model of multiple sclerosis

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Basic principles of immunological surveillance of the normal central nervous system

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Immunomodulatory effects of 3-hydroxy-3-methylglutaryl coenzyme-A reductase inhibitors, potential therapy for relapsing remitting multiple sclerosis

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Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site

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Cholesterol-lowering statins possess anti-inflammatory activity that might be useful for treatment of MS

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12 December 2020

Simvastatin inhibits the MHC class II pathway of antigen presentation by impairing Ras superfamily GTPases.

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12 December 2020

Inhibition of phosphoinositide 3 kinase-Akt (protein kinase B)-nuclear factor-kappa B pathway by lovastatin limits endothelial-monocyte cell interaction

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12 December 2020

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12 December 2020

Simvastatin inhibits IL-17 secretion by targeting multiple IL-17-regulatory cytokines and by inhibiting the expression of IL-17 transcription factor RORC in CD4+ lymphocytes.

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12 December 2020

Isoprenoids determine Th1/Th2 fate in pathogenic T cells, providing a mechanism of modulation of autoimmunity by atorvastatin

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12 December 2020

SOCS: role in inflammation, allergy and homeostasis

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12 December 2020

Statins as a newly recognized type of immunomodulator

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12 December 2020

IL-21 is produced by Th17 cells and drives IL-17 production in a STAT3-dependent manner

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12 December 2020

Autoimmune inflammation from the Th17 perspective

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12 December 2020

Pharmacology of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors (statins), including rosuvastatin and pitavastatin

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Statins as immunomodulators: comparison with interferon-beta 1b in MS.

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Statins induce suppressor of cytokine signaling-3 in macrophages

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12 December 2020

Lovastatin and phenylacetate inhibit the induction of nitric oxide synthase and cytokines in rat primary astrocytes, microglia, and macrophages

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12 December 2020

Statins in the treatment of central nervous system autoimmune disease

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12 December 2020

Role of astrocytes in antigen presentation and naive T-cell activation

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12 December 2020

Immunology of multiple sclerosis

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12 December 2020

Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis

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12 December 2020

Pleiotropic effects of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors

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12 December 2020

Distinct regulation of interleukin-17 in human T helper lymphocytes

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12 December 2020

Lovastatin inhibits bone marrow-derived dendritic cell maturation and upregulates proinflammatory cytokine production

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12 December 2020

Simvastatin inhibits the monocyte expression of proinflammatory cytokines in patients with hypercholesterolemia

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12 December 2020

Amelioration of experimental allergic encephalomyelitis in Lewis rats by lovastatin

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12 December 2020

10.1007/S12026-008-8019-Z

Identifiers

DOI

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18 August 2017

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PubMed ID

18484192