The histone deacetylase inhibitor sodium valproate causes limited transcriptional change in mouse embryonic stem cells but selectively overrides Polycomb-mediated Hoxb silencing (Q37160553)

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scientific article published on May 2013

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English	The histone deacetylase inhibitor sodium valproate causes limited transcriptional change in mouse embryonic stem cells but selectively overrides Polycomb-mediated Hoxb silencing	scientific article published on May 2013

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scholarly article

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29 February 2020

The histone deacetylase inhibitor sodium valproate causes limited transcriptional change in mouse embryonic stem cells but selectively overrides Polycomb-mediated Hoxb silencing (English)

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29 February 2020

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29 February 2020

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29 February 2020

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Anton Wutz

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29 February 2020

author name string

Elsa Boudadi

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29 February 2020

Hannah Stower

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29 February 2020

Charlotte E Rutledge

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29 February 2020

Laura P O'Neill

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29 February 2020

Karl P Nightingale

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29 February 2020

Bryan M Turner

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29 February 2020

publication date

1 May 2013

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29 February 2020

Epigenetics & Chromatin

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29 February 2020

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29 February 2020

1

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29 February 2020

https://scigraph.springernature.com/pub.10.1186/1756-8935-6-11

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Valproic acid downregulates RBP4 and elicits hypervitaminosis A-teratogenesis--a kinetic analysis on retinol/retinoic acid homeostatic system

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The adjustable nucleosome: an epigenetic signaling module

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6 September 2017

Genes are often sheltered from the global histone hyperacetylation induced by HDAC inhibitors

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6 September 2017

Pluripotency-related, valproic acid (VPA)-induced genome-wide histone H3 lysine 9 (H3K9) acetylation patterns in embryonic stem cells

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6 September 2017

Role for Dpy-30 in ES cell-fate specification by regulation of H3K4 methylation within bivalent domains

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6 September 2017

Regulation of chromatin by histone modifications

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6 September 2017

Distinct roles of GCN5/PCAF-mediated H3K9ac and CBP/p300-mediated H3K18/27ac in nuclear receptor transactivation

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6 September 2017

Epigenomic reorganization of the clustered Hox genes in embryonic stem cells induced by retinoic acid

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6 September 2017

Characterization of an antagonistic switch between histone H3 lysine 27 methylation and acetylation in the transcriptional regulation of Polycomb group target genes

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6 September 2017

Histone deacetylases and epigenetic therapies of hematological malignancies

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Genome-wide mapping of HATs and HDACs reveals distinct functions in active and inactive genes

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6 September 2017

Transcription-independent heritability of induced histone modifications in the mouse preimplantation embryo

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6 September 2017

Histone deacetylase inhibitors: Potential in cancer therapy

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6 September 2017

Histone deacetylase inhibitors as anti-neoplastic agents.

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6 September 2017

The many roles of histone deacetylases in development and physiology: implications for disease and therapy

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6 September 2017

Teratogenicity of antiepileptic medications

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6 September 2017

Histone modifying enzymes: structures, mechanisms, and specificities

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6 September 2017

Valproic acid as epigenetic cancer drug: preclinical, clinical and transcriptional effects on solid tumors

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6 September 2017

How does noncoding transcription regulate Hox genes?

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6 September 2017

Dosage compensation in the mouse balances up-regulation and silencing of X-linked genes

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6 September 2017

Histone deacetylase inhibitors: molecular mechanisms of action

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6 September 2017

Genome-wide maps of chromatin state in pluripotent and lineage-committed cells

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6 September 2017

Butyrate mediates decrease of histone acetylation centered on transcription start sites and down-regulation of associated genes

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6 September 2017

Cross-talk between histone modifications in response to histone deacetylase inhibitors: MLL4 links histone H3 acetylation and histone H3K4 methylation

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6 September 2017

Mammalian sirtuins--emerging roles in physiology, aging, and calorie restriction

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6 September 2017

Substrate and functional diversity of lysine acetylation revealed by a proteomics survey

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6 September 2017

HDAC1 acetylation is linked to progressive modulation of steroid receptor-induced gene transcription

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6 September 2017

A bivalent chromatin structure marks key developmental genes in embryonic stem cells

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6 September 2017

Chromatin signatures of pluripotent cell lines

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6 September 2017

Valproic acid-induced skeletal malformations: associated gene expression cascades

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6 September 2017

Teratogenicity of sodium valproate

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6 September 2017

The pathophysiology of HOX genes and their role in cancer.

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6 September 2017

Chromatin decondensation and nuclear reorganization of the HoxB locus upon induction of transcription

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6 September 2017

Active genes are tri-methylated at K4 of histone H3

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6 September 2017

The histone deacetylase inhibitor trichostatin A blocks progesterone receptor-mediated transactivation of the mouse mammary tumor virus promoter in vivo.

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6 September 2017

Human class I histone deacetylase complexes show enhanced catalytic activity in the presence of ATP and co-immunoprecipitate with the ATP-dependent chaperone protein Hsp70

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6 September 2017

Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen

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14 September 2017

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29 September 2017

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29 September 2017

The expression of a small fraction of cellular genes is changed in response to histone hyperacetylation.

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29 September 2017

Histone acetylation and the maintenance of chromatin compaction by Polycomb repressive complexes

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27 June 2018

Valproic acid increases formation of reactive oxygen species and induces apoptosis in postimplantation embryos: a role for oxidative stress in valproic acid-induced neural tube defects.

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3 September 2018

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3 September 2018

A mouse model for valproate teratogenicity: parental effects, homeotic transformations, and altered HOX expression.

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3 September 2018

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21 January 2018

Coordinate expression of the murine Hox-5 complex homoeobox-containing genes during limb pattern formation

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21 January 2018

The promotion of stemness and pluripotency following feeder-free culture of embryonic stem cells on collagen-grafted 3-dimensional nanofibrous scaffold

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12 December 2020

based on heuristic

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Relative overexpression of X-linked genes in mouse embryonic stem cells is consistent with Ohno's hypothesis

1 reference

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12 December 2020

based on heuristic

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StatBite: FDA oncology drug product approvals in 2009

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Oral valproic acid for epilepsy--long-term experience in therapy and side effects

1 reference

https://pubmed.ncbi.nlm.nih.gov/23634885

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based on heuristic

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Identifiers

10.1186/1756-8935-6-11

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29 February 2020

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29 February 2020

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29 February 2020

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