Genetic and epigenetic variants contributing to clofarabine cytotoxicity (Q37153800)

18 August 2017

Genetic and epigenetic variants contributing to clofarabine cytotoxicity (English)

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18 August 2017

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2

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18 August 2017

7

Hae Kyung Im

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Erika L Moen

object named as

Erika L Moen

5

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author name string

Michael T Eadon

1

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18 August 2017

Amy L Stark

3

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18 August 2017

Xu Zhang

4

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18 August 2017

Shannon M Delaney

6

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18 August 2017

Hae Kyung Im

7

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18 August 2017

Patrick N Cunningham

8

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18 August 2017

Wei Zhang

9

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18 August 2017

M Eileen Dolan

10

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18 August 2017

29 May 2013

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18 August 2017

Human Molecular Genetics

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18 August 2017

22

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18 August 2017

19

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18 August 2017

4007-4020

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describes a project that uses

18 August 2017

Cytoscape

1 reference

9 June 2022

https://europepmc.org/search?query=(METHODS:'Cytoscape')

inferred from PubMed Central ID database lookup

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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Extensive methylation of promoter sequences silences lentiviral transgene expression during stem cell differentiation in vivo

6 September 2017

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Mixed effects modeling of proliferation rates in cell-based models: consequence for pharmacogenomics and cancer

6 September 2017

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Population-specificity of human DNA methylation

6 September 2017

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A comparison of association methods for cytotoxicity mapping in pharmacogenomics

6 September 2017

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Clofarabine plus low-dose cytarabine followed by clofarabine plus low-dose cytarabine alternating with decitabine in acute myeloid leukemia frontline therapy for older patients

6 September 2017

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Lymphoblastoid cell lines in pharmacogenomic discovery and clinical translation

6 September 2017

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An eQTL-based method identifies CTTN and ZMAT3 as pemetrexed susceptibility markers

6 September 2017

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Phase I-II study of clofarabine-melphalan-alemtuzumab conditioning for allogeneic hematopoietic cell transplantation

6 September 2017

1 reference

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Bag3 promotes resistance to apoptosis through Bcl-2 family members in non-small cell lung cancer

6 September 2017

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Failure of hypomethylating agent-based therapy in myelodysplastic syndromes

6 September 2017

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Genetic variation predicting cisplatin cytotoxicity associated with overall survival in lung cancer patients receiving platinum-based chemotherapy

6 September 2017

1 reference

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Genetic variants in cytosolic 5'-nucleotidase II are associated with its expression and cytarabine sensitivity in HapMap cell lines and in patients with acute myeloid leukemia.

6 September 2017

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MicroRNA 345, a methylation-sensitive microRNA is involved in cell proliferation and invasion in human colorectal cancer

6 September 2017

1 reference

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Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3766179

Identification and replication of loci involved in camptothecin-induced cytotoxicity using CEPH pedigrees

6 September 2017

1 reference

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Next generation genome-wide association tool: design and coverage of a high-throughput European-optimized SNP array

6 September 2017

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BAG3 protein is overexpressed in human glioblastoma and is a potential target for therapy

6 September 2017

1 reference

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Human epigenome data reveal increased CpG methylation in alternatively spliced sites and putative exonic splicing enhancers

6 September 2017

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Relationship between gene body DNA methylation and intragenic H3K9me3 and H3K36me3 chromatin marks

6 September 2017

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Global hypomethylation identifies Loci targeted for hypermethylation in head and neck cancer

6 September 2017

1 reference

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Germline polymorphisms discovered via a cell-based, genome-wide approach predict platinum response in head and neck cancers

6 September 2017

1 reference

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Impact of genetic variation in FKBP5 on clinical response in pediatric acute myeloid leukemia patients: a pilot study.

6 September 2017

1 reference

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DNA methylation patterns associate with genetic and gene expression variation in HapMap cell lines

6 September 2017

1 reference

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Comparison of Beta-value and M-value methods for quantifying methylation levels by microarray analysis

6 September 2017

1 reference

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Southwest Oncology Group Study S0530: a phase 2 trial of clofarabine and cytarabine for relapsed or refractory acute lymphocytic leukaemia

6 September 2017

1 reference

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A genome-wide approach identifies that the aspartate metabolism pathway contributes to asparaginase sensitivity.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3766179

The synergistic cytotoxicity of clofarabine, fludarabine and busulfan in AML cells involves ATM pathway activation and chromatin remodeling

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3766179

Chemotherapeutic drug susceptibility associated SNPs are enriched in expression quantitative trait loci

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3766179

Understanding mechanisms underlying human gene expression variation with RNA sequencing

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3766179

Pharmacogenomic discovery using cell-based models

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3766179

SCAN: SNP and copy number annotation

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3766179

Genetic factors influencing cytarabine therapy

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3766179

Common regulatory variation impacts gene expression in a cell type-dependent manner

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3766179

Population-specific genetic variants important in susceptibility to cytarabine arabinoside cytotoxicity.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3766179

Genetic variants contributing to daunorubicin-induced cytotoxicity

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3766179

Evaluation of genetic variation contributing to differences in gene expression between populations

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3766179

Population genomics of human gene expression

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3766179

Identification of genetic variants contributing to cisplatin-induced cytotoxicity by use of a genomewide approach

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3766179

A genome-wide approach to identify genetic variants that contribute to etoposide-induced cytotoxicity.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3766179

Effect of population and gender on chemotherapeutic agent-induced cytotoxicity

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3766179

The BTB-kelch protein KLHL6 is involved in B-lymphocyte antigen receptor signaling and germinal center formation

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3766179

Specific over-expression of deltex and a new Kelch-like protein in human germinal center B cells

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3766179

The anti-apoptotic protein BAG-3 is overexpressed in pancreatic cancer and induced by heat stress in pancreatic cancer cell lines

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3766179

Identification and characterization of SEB, a novel protein that binds to the acute undifferentiated leukemia-associated protein SET

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3766179

A general test of association for quantitative traits in nuclear families

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3766179

Bis, a Bcl-2-binding protein that synergizes with Bcl-2 in preventing cell death

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3766179

The effects of EBV transformation on gene expression levels and methylation profiles

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3766179

SETBP1 overexpression is a novel leukemogenic mechanism that predicts adverse outcome in elderly patients with acute myeloid leukemia.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3766179

Clofarabine induces hypomethylation of DNA and expression of Cancer-Testis antigens

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3766179

Association of thymidylate synthase variants with 5-fluorouracil cytotoxicity

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3766179

Pharmacogenetics of deoxycytidine kinase: identification and characterization of novel genetic variants.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3766179

Discovery of epigenetically silenced genes in acute myeloid leukemias

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3766179

A comparison of the transportability, and its role in cytotoxicity, of clofarabine, cladribine, and fludarabine by recombinant human nucleoside transporters produced in three model expression systems

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3766179

Functional consequences of PRPF39 on distant genes and cisplatin sensitivity

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3766179

High density DNA methylation array with single CpG site resolution

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3766179

De novo mutations of SETBP1 cause Schinzel-Giedion syndrome

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3766179

European development of clofarabine as treatment for older patients with acute myeloid leukemia considered unsuitable for intensive chemotherapy

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3766179

Renal excretion of clofarabine: assessment of dose-linearity and role of renal transport systems on drug excretion

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3766179

BAG3 gene silencing sensitizes leukemic cells to Bortezomib-induced apoptosis

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3766179

Histone H3 modifications associated with differentiation and long-term culture of mesenchymal adipose stem cells

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3766179

In vitro cytotoxicity of nelarabine, clofarabine and flavopiridol in paediatric acute lymphoblastic leukaemia.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3766179

Fusion of NUP98 and the SET binding protein 1 (SETBP1) gene in a paediatric acute T cell lymphoblastic leukaemia with t(11;18)(p15;q12).

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3766179

Phase 2 clinical and pharmacologic study of clofarabine in patients with refractory or relapsed acute leukemia

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3766179

Schinzel-Giedion syndrome and congenital megacalyces.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3766179

Chromatin organization marks exon-intron structure

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3766179

Hydronephrosis in Schinzel-Giedion syndrome: an important clue for the diagnosis

4 December 2018

1 reference

12 December 2020

EBV transformation and cell culturing destabilizes DNA methylation in human lymphoblastoid cell lines

1 reference

12 December 2020

Clofarabine-associated acute kidney injury and proteinuria

1 reference

12 December 2020

Tissue specificity of genetic regulation of gene expression

1 reference

12 December 2020

Identifiers

DOI

10.1093/HMG/DDT240

1 reference

18 August 2017

1 reference

18 August 2017

1 reference