The inhibition of TDP-43 mitochondrial localization blocks its neuronal toxicity (Q37153120)

18 August 2017

The inhibition of TDP-43 mitochondrial localization blocks its neuronal toxicity (English)

1 reference

18 August 2017

1 reference

1

1 reference

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9 June 2020

Junjie Lu

3

1 reference

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Edroaldo Lummertz da Rocha

9 June 2020

10

1 reference

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9 June 2020

4

Sandra L Siedlak

1 reference

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9 June 2020

author name string

Luwen Wang

2

1 reference

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9 June 2020

Hisashi Fujioka

5

1 reference

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9 June 2020

Jingjing Liang

6

1 reference

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9 June 2020

Sirui Jiang

7

1 reference

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9 June 2020

Xiaopin Ma

8

1 reference

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9 June 2020

Zhen Jiang

9

1 reference

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9 June 2020

Max Sheng

11

1 reference

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9 June 2020

Heewon Choi

12

1 reference

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9 June 2020

Paul H Lerou

13

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9 June 2020

Hu Li

14

1 reference

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9 June 2020

Xinglong Wang

15

1 reference

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9 June 2020

language of work or name

English

0 references

publication date

27 June 2016

1 reference

18 August 2017

1 reference

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9 June 2020

volume

22

1 reference

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9 June 2020

issue

8

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9 June 2020

page(s)

869-878

1 reference

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describes a project that uses

9 June 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4974139/fullTextXML

inferred from PubMed Central ID database lookup

exact match

https://scigraph.springernature.com/pub.10.1038/nm.4130

0 references

cites work

The phenotypic variability of amyotrophic lateral sclerosis

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Prevention of intestinal obstruction reveals progressive neurodegeneration in mutant TDP-43 (A315T) mice

6 September 2017

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Partial loss of TDP-43 function causes phenotypes of amyotrophic lateral sclerosis.

6 September 2017

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Disease causing mutants of TDP-43 nucleic acid binding domains are resistant to aggregation and have increased stability and half-life

6 September 2017

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Increased metal content in the TDP-43(A315T) transgenic mouse model of frontotemporal lobar degeneration and amyotrophic lateral sclerosis.

6 September 2017

1 reference

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Staging TDP-43 pathology in Alzheimer's disease

6 September 2017

1 reference

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Abnormal mitochondrial transport and morphology are common pathological denominators in SOD1 and TDP43 ALS mouse models

6 September 2017

1 reference

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Mitochondrial cristae shape determines respiratory chain supercomplexes assembly and respiratory efficiency

6 September 2017

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The ALS disease-associated mutant TDP-43 impairs mitochondrial dynamics and function in motor neurons

6 September 2017

1 reference

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Endogenous progesterone levels and frontotemporal dementia: modulation of TDP-43 and Tau levels in vitro and treatment of the A315T TARDBP mouse model.

6 September 2017

1 reference

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ALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor neuron disease without aggregation or loss of nuclear TDP-43.

6 September 2017

1 reference

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Mitochondrial division in rat cardiomyocytes: an electron microscope study

6 September 2017

1 reference

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Advances in understanding the molecular basis of frontotemporal dementia

6 September 2017

1 reference

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Targeted depletion of TDP-43 expression in the spinal cord motor neurons leads to the development of amyotrophic lateral sclerosis-like phenotypes in mice

6 September 2017

1 reference

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TDP-43: gumming up neurons through protein-protein and protein-RNA interactions

6 September 2017

1 reference

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Gains or losses: molecular mechanisms of TDP43-mediated neurodegeneration

6 September 2017

1 reference

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Expression of mutant TDP-43 induces neuronal dysfunction in transgenic mice

6 September 2017

1 reference

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Decreased cytochrome c oxidase subunit VIIa in aged rat heart mitochondria: immunocytochemistry

6 September 2017

1 reference

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Pink1 regulates the oxidative phosphorylation machinery via mitochondrial fission

6 September 2017

1 reference

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The human brain in a dish: the promise of iPSC-derived neurons

6 September 2017

1 reference

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Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43.

6 September 2017

1 reference

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Identification of neuronal RNA targets of TDP-43-containing ribonucleoprotein complexes

6 September 2017

1 reference

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TDP-43 and FUS in amyotrophic lateral sclerosis and frontotemporal dementia

6 September 2017

1 reference

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Mitochondrial protein import: from proteomics to functional mechanisms

6 September 2017

1 reference

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Wild-type human TDP-43 expression causes TDP-43 phosphorylation, mitochondrial aggregation, motor deficits, and early mortality in transgenic mice

6 September 2017

1 reference

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Cytoplasmic mislocalization of TDP-43 is toxic to neurons and enhanced by a mutation associated with familial amyotrophic lateral sclerosis

6 September 2017

1 reference

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TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration

6 September 2017

1 reference

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Impaired balance of mitochondrial fission and fusion in Alzheimer's disease

6 September 2017

1 reference

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Amyloid-beta overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins

6 September 2017

1 reference

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The amyloid beta-peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae

6 September 2017

1 reference

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Dynamin-like protein 1 reduction underlies mitochondrial morphology and distribution abnormalities in fibroblasts from sporadic Alzheimer's disease patients

6 September 2017

1 reference

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Phosphorylated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis.

6 September 2017

1 reference

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RNA recognition motifs: boring? Not quite

6 September 2017

1 reference

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TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis

6 September 2017

1 reference

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TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis

6 September 2017

1 reference

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Multiple pathways for sorting mitochondrial precursor proteins

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4974139

Multiple roles of TDP-43 in gene expression, splicing regulation, and human disease.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4974139

TDP-43 immunoreactivity in hippocampal sclerosis and Alzheimer's disease

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4974139

Locating proteins in the cell using TargetP, SignalP and related tools

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4974139

Biochemical assays of respiratory chain complex activity

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4974139

Culturing hippocampal neurons

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4974139

Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4974139

Design and structure of peptide and peptidomimetic antagonists of protein-protein interaction.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4974139

De novo mutations in the mitochondrial ND3 gene as a cause of infantile mitochondrial encephalopathy and complex I deficiency

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4974139

The mitochondrial ND6 gene is a hot spot for mutations that cause Leber's hereditary optic neuropathy

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4974139

The mitochondrial death/life regulator in apoptosis and necrosis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4974139

Computational method to predict mitochondrially imported proteins and their targeting sequences

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4974139

Characterizing the RNA targets and position-dependent splicing regulation by TDP-43.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4974139

Organization of the mitochondrial translation machinery studied in situ by cryoelectron tomography

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4974139

The distribution of genomic variations in human iPSCs is related to replication-timing reorganization during reprogramming.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4974139

Human iPSC-based modeling of late-onset disease via progerin-induced aging

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4974139

Bioenergetic analysis of isolated cerebrocortical nerve terminals on a microgram scale: spare respiratory capacity and stochastic mitochondrial failure

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4974139

C57BL/6J congenic Prp-TDP43A315T mice develop progressive neurodegeneration in the myenteric plexus of the colon without exhibiting key features of ALS.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4974139

Identification of RNA bound to the TDP-43 ribonucleoprotein complex in the adult mouse brain.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4974139

TDP-43 in ubiquitinated inclusions in the inferior olives in frontotemporal lobar degeneration and in other neurodegenerative diseases: a degenerative process distinct from normal ageing.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4974139

Maturation process of TDP-43-positive neuronal cytoplasmic inclusions in amyotrophic lateral sclerosis with and without dementia

3 September 2018

1 reference

12 December 2020

Severe subcortical TDP-43 pathology in sporadic frontotemporal lobar degeneration with motor neuron disease

1 reference

12 December 2020

Necroptosis: a specialized pathway of programmed necrosis

1 reference

12 December 2020

Activation of p38 kinase links tau phosphorylation, oxidative stress, and cell cycle-related events in Alzheimer disease

1 reference

12 December 2020

TDP43-positive intraneuronal inclusions in a patient with motor neuron disease and Parkinson's disease

1 reference

12 December 2020

A rotarod suitable for quantitative measurements of motor incoordination in naive mice

1 reference

12 December 2020

A stable lead by modification of Sato's method

1 reference

12 December 2020

Identifiers

DOI

10.1038/NM.4130

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27348499%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

9 June 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27348499%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

1 reference