Total synthesis of apoptolidin A. (Q37121878)

18 August 2017

Total synthesis of apoptolidin A. (English)

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18 August 2017

Michael T Crimmins

1

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18 August 2017

Hamish S Christie

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2

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18 August 2017

Alan Long

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3

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18 August 2017

Kleem Chaudhary

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4

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18 August 2017

language of work or name

English

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publication date

1 February 2009

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18 August 2017

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18 August 2017

11

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18 August 2017

4

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18 August 2017

831-834

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Synthesis and evaluation of the cytotoxicity of apoptolidinones A and D

18 August 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2653204

Studies on the synthesis of apoptolidin A. 2. Synthesis of the disaccharide unit

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2653204

Studies on the synthesis of apoptolidin A. 1. Synthesis of the C(1)-C(11) fragment.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2653204

Apoptolidin: induction of apoptosis by a natural product

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2653204

Apoptolidins B and C: isolation, structure determination, and biological activity

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2653204

Apoptolidin, a selective cytotoxic agent, is an inhibitor of F0F1-ATPase

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2653204

Understanding and exploiting the mechanistic basis for selectivity of polyketide inhibitors of F(0)F(1)-ATPase

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2653204

Synthesis and activity of a new generation of ruthenium-based olefin metathesis catalysts coordinated with 1,3-dimesityl-4,5-dihydroimidazol-2-ylidene ligands

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2653204

Isolation, structure determination, and anti-cancer activity of apoptolidin D.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2653204

Total synthesis of apoptolidin: completion of the synthesis and analogue synthesis and evaluation.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2653204

Apoptolidinone A: synthesis of the apoptolidin A aglycone.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2653204

A general model for selectivity in olefin cross metathesis

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2653204

Enantioselective synthesis of apoptolidinone: exploiting the versatility of thiazolidinethione chiral auxiliaries

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2653204

Synthesis of the C(1)-C(11) polyene fragment of apoptolidin with a new sulfur dioxide-based organic chemistry

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2653204

Total synthesis of apoptolidin: construction of enantiomerically pure fragments

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2653204

Total Synthesis of Apoptolidin: Part 1. Retrosynthetic Analysis and Construction of Building Blocks We thank Dr. D. H. Huang and Dr. G. Siuzdak for NMR spectroscopic and mass spectrometric assistance, respectively. This work was financially supporte

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2653204

Synthesis of Apoptolidinone This work was supported by the Fonds der Chemischen Industrie, Schering AG, and the Schering Forschungsgesellschaft. We thank Prof. Dr. U. Eder (Schering AG, Berlin) for stimulating and helpful discussions.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2653204

Synthesis of the apoptosis inducing agent apoptolidin. Assembly of the C(16)-C(28) fragment

3 September 2018

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12 December 2020

Structure-activity relationships within a family of selectively cytotoxic macrolide natural products

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12 December 2020

Toward a structure-activity relationship for apoptolidin: selective functionalization of the hydroxyl group array

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12 December 2020

Isoapoptolidin: structure and activity of the ring-expanded isomer of apoptolidin

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12 December 2020

Facile synthetic access to and biological evaluation of the macrocyclic core of apoptolidin

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12 December 2020

Enantioselective preparation of the C1-C11 fragment of apoptolidin

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12 December 2020

Total synthesis of apoptolidin

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12 December 2020

Total synthesis of apoptolidinone

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12 December 2020

Enantioselective synthesis of apoptolidin sugars

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12 December 2020

Apoptolidin A: total synthesis and partially glycosylated analogues

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12 December 2020

Total Synthesis of Apoptolidin: Part 2. Coupling of Key Building Blocks and Completion of the Synthesis We thank Dr. C. Khosla and Dr. Y. Hayakawa for generous gifts of apoptolidin, and Dr. D. H. Huang and Dr. G. Siuzdak for NMR spectroscopic and ma

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12 December 2020

Synthesis of Apoptolidinone.

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12 December 2020

Apoptolidin, a new apoptosis inducer in transformed cells from Nocardiopsis sp

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12 December 2020

Identifiers

DOI

10.1021/OL802829N

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18 August 2017

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18 August 2017

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