The roles of MAPKs in disease (Q37112520)

18 August 2017

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title

The roles of MAPKs in disease (English)

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18 August 2017

Michael C Lawrence

1

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18 August 2017

Arif Jivan

2

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18 August 2017

Chunli Shao

3

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18 August 2017

Lingling Duan

4

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18 August 2017

Daryl Goad

5

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18 August 2017

Elma Zaganjor

6

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18 August 2017

Jihan Osborne

7

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18 August 2017

Kathleen McGlynn

8

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18 August 2017

Steve Stippec

9

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18 August 2017

Svetlana Earnest

10

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18 August 2017

Wei Chen

11

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18 August 2017

Melanie H Cobb

12

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18 August 2017

1 April 2008

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18 August 2017

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18 August 2017

18

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18 August 2017

436-442

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18 August 2017

4

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https://scigraph.springernature.com/pub.10.1038/cr.2008.37

18 August 2017

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cites work

Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer

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https://api.crossref.org/works/10.1038%2FCR.2008.37

Inhibition of p38 MAP kinase as a therapeutic strategy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.37

A central role for JNK in obesity and insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.37

Differential regulation and properties of MAPKs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.37

Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.37

The extracellular signal-regulated kinase: multiple substrates regulate diverse cellular functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.37

Regulation of histone acetylation during memory formation in the hippocampus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.37

Regulation of insulin gene transcription by ERK1 and ERK2 in pancreatic beta cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.37

An essential function of the mitogen-activated protein kinase Erk2 in mouse trophoblast development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.37

Germline mutations in genes within the MAPK pathway cause cardio-facio-cutaneous syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.37

Mammalian Ras interacts directly with the serine/threonine kinase Raf

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.37

Raf-1 activates MAP kinase-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.37

Cellular Oncogenes and Multistep Carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.37

Multiple Ras functions can contribute to mammalian cell transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.37

A genome-wide survey of RAS transformation targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.37

Signal pathways which promote invasion and metastasis: critical and distinct contributions of extracellular signal-regulated kinase and Ral-specific guanine exchange factor pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.37

Signaling through RAS-RAF-MEK-ERK: from basics to bedside.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.37

Epidermal growth factor activates m-calpain (calpain II), at least in part, by extracellular signal-regulated kinase-mediated phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.37

Sustained activation of the mitogen-activated protein kinase pathway. A mechanism underlying receptor tyrosine kinase specificity for matrix metalloproteinase-9 induction and cell migration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.37

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.37

Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.37

c-Jun N-terminal kinase (JNK) mediates feedback inhibition of the insulin signaling cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.37

Regulation of MAP Kinase Signaling Modules by Scaffold Proteins in Mammals

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.37

Ste5 tethers multiple protein kinases in the MAP kinase cascade required for mating in S. cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.37

Complexes between STE5 and components of the pheromone-responsive mitogen-activated protein kinase module

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.37

The Ste5 scaffold allosterically modulates signaling output of the yeast mating pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.37

The Elk-1 ETS-domain transcription factor contains a mitogen-activated protein kinase targeting motif.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.37

Multiple docking sites on substrate proteins form a modular system that mediates recognition by ERK MAP kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.37

A conserved docking motif in MAP kinases common to substrates, activators and regulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.37

Docking domains and substrate-specificity determination for MAP kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.37

The N-terminal ERK-binding site of MEK1 is required for efficient feedback phosphorylation by ERK2 in vitro and ERK activation in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.37

An ERK2 docking site in the Pointed domain distinguishes a subset of ETS transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.37

Crystal structures of MAP kinase p38 complexed to the docking sites on its nuclear substrate MEF2A and activator MKK3b

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.37

Spatially separate docking sites on ERK2 regulate distinct signaling events in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.37

Hydrophobic as well as charged residues in both MEK1 and ERK2 are important for their proper docking

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.37

Identification of an extracellular signal-regulated kinase (ERK) docking site in ribosomal S6 kinase, a sequence critical for activation by ERK in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.37

Phosphorylation of p90 ribosomal S6 kinase (RSK) regulates extracellular signal-regulated kinase docking and RSK activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.37

Cell condition-dependent regulation of ERK5 by cAMP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.37

Cyclic AMP selectively uncouples mitogen-activated protein kinase cascades from activating signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.37

Activation of the Erk pathway is required for TGF-beta1-induced EMT in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.37

SMAD3 expression is regulated by mitogen-activated protein kinase kinase-1 in epithelial and smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.37

Calcium restriction allows cAMP activation of the B-Raf/ERK pathway, switching cells to a cAMP-dependent growth-stimulated phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.37

PDGFRalphaalpha signaling is regulated through the primary cilium in fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.37

The polycystin 1-C-terminal fragment stimulates ERK-dependent spreading of renal epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.37

Piecing together a ciliome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.37

Cyclic AMP activates B-Raf and ERK in cyst epithelial cells from autosomal-dominant polycystic kidneys

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.37

Nuclear localization and regulation of erk- and rsk-encoded protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.37

Stimulus-coupled spatial restriction of extracellular signal-regulated kinase 1/2 activity contributes to the specificity of signal-response pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.37

Platelet-derived growth factor activates mitogen-activated protein kinase in isolated caveolae

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.37

Association of mitogen-activated protein kinase with the microtubule cytoskeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.37

Modulation of the dynamic instability of tubulin assembly by the microtubule-associated protein tau

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.37

In vitro effects on microtubule dynamics of purified Xenopus M phase-activated MAP kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.37

A constitutively active and nuclear form of the MAP kinase ERK2 is sufficient for neurite outgrowth and cell transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.37

ERK3 is a constitutively nuclear protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.37

Calponin and mitogen-activated protein kinase signaling in differentiated vascular smooth muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.37

PED/PEA-15 gene controls glucose transport and is overexpressed in type 2 diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.37

Expression of MAT1/PEA-15 mRNA isoforms during physiological and neoplastic changes in the mouse mammary gland.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.37

Mxi2 promotes stimulus-independent ERK nuclear translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.37

Overexpression of the ped/pea-15 gene causes diabetes by impairing glucose-stimulated insulin secretion in addition to insulin action

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.37

PEA-15 mediates cytoplasmic sequestration of ERK MAP kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.37

The death effector domain protein PEA-15 prevents nuclear entry of ERK2 by inhibiting required interactions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.37

Glucose, other secretagogues, and nerve growth factor stimulate mitogen-activated protein kinase in the insulin-secreting beta-cell line, INS-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.37

Activation of mitogen-activating protein kinase by glucose is not required for insulin secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.37

Rapid activation and nuclear translocation of mitogen-activated protein kinases in response to physiological concentration of glucose in the MIN6 pancreatic beta cell line.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.37

Regulation of ERK1 and ERK2 by glucose and peptide hormones in pancreatic beta cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.37

Inhibition of glucose-stimulated activation of extracellular signal-regulated protein kinases 1 and 2 by epinephrine in pancreatic beta-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.37

cAMP-dependent protein kinase and Ca2+ influx through L-type voltage-gated calcium channels mediate Raf-independent activation of extracellular regulated kinase in response to glucagon-like peptide-1 in pancreatic beta-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.37

ERK1/2-dependent activation of transcription factors required for acute and chronic effects of glucose on the insulin gene promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.37

The insulin gene promoter. A simplified nomenclature.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.37

The reduction of insulin gene transcription in HIT-T15 beta cells chronically exposed to high glucose concentration is associated with the loss of RIPE3b1 and STF-1 transcription factor expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.37

Pancreatic beta-cell-specific repression of insulin gene transcription by CCAAT/enhancer-binding protein beta. Inhibitory interactions with basic helix-loop-helix transcription factor E47.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.37

Endoplasmic reticulum stress and the development of diabetes: a review

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.37

Endoplasmic reticulum stress-mediated apoptosis in pancreatic beta-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.37

CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.37

Differential regulation of CHOP-10/GADD153 gene expression by MAPK signaling in pancreatic beta-cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.37

Signal transduction through MAP kinase cascades

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.37

7 January 2021

Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.37

7 January 2021

ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.37

7 January 2021

Requirement of the MAP kinase signaling pathways for mouse preimplantation development

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.37

7 January 2021

Transformation of mammalian cells by constitutively active MAP kinase kinase

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.37

7 January 2021

Rotation of photoreceptor clusters in the developing Drosophila eye requires the nemo gene

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.37

7 January 2021

Nuclear shuttling of yeast scaffold Ste5 is required for its recruitment to the plasma membrane and activation of the mating MAPK cascade

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.37

7 January 2021

Docking interactions induce exposure of activation loop in the MAP kinase ERK2

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.37

7 January 2021

Mutations in ERK2 Binding Sites Affect Nuclear Entry

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.37

7 January 2021

Extracellular signal-regulated kinase inhibition slows disease progression in mice with polycystic kidney disease

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.37

7 January 2021

Effect of different ERK2 protein localizations on prognosis of patients with invasive breast carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.37

7 January 2021

Cellular expression, developmental regulation, and phylogenic conservation of PEA-15, the astrocytic major phosphoprotein and protein kinase C substrate.

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.37

7 January 2021

Genetics of type 2 diabetes mellitus

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.37

7 January 2021

Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.37

7 January 2021

Identifiers

DOI

10.1038/CR.2008.37

1 reference

Dimensions Publication ID

18 August 2017

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