Preclinical evidence of multiple mechanisms underlying trastuzumab resistance in gastric cancer. (Q37109776)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26919099%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

title

Preclinical evidence of multiple mechanisms underlying trastuzumab resistance in gastric cancer (English)

1 reference

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9 March 2020

1 reference

1

1 reference

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9 March 2020

Michele Zanoni

2

1 reference

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9 March 2020

Sara Pignatta

3

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9 March 2020

Michela Tebaldi

6

1 reference

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9 March 2020

Gianluca Tedaldi

7

1 reference

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9 March 2020

Anna Tesei

8

1 reference

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9 March 2020

author name string

Alberto Del Rio

4

1 reference

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9 March 2020

Silvia Carloni

5

1 reference

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9 March 2020

language of work or name

English

0 references

publication date

1 April 2016

1 reference

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9 March 2020

1 reference

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9 March 2020

volume

7

1 reference

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9 March 2020

issue

14

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9 March 2020

page(s)

18424-18439

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Development of trastuzumab-resistant human gastric carcinoma cell lines and mechanisms of drug resistance

9 March 2020

cites work

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Anti-HER3 Monoclonal Antibody Inhibits Acquired Trastuzumab-Resistant Gynecologic Cancers

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Nuclear HER4 mediates acquired resistance to trastuzumab and is associated with poor outcome in HER2 positive breast cancer

14 September 2017

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14 September 2017

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Lapatinib plus paclitaxel versus paclitaxel alone in the second-line treatment of HER2-amplified advanced gastric cancer in Asian populations: TyTAN--a randomized, phase III study

14 September 2017

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An heregulin-EGFR-HER3 autocrine signaling axis can mediate acquired lapatinib resistance in HER2+ breast cancer models

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Mutant PIK3CA accelerates HER2-driven transgenic mammary tumors and induces resistance to combinations of anti-HER2 therapies

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The HER2-miR125a5p/miR125b loop in gastric and esophageal carcinogenesis

14 September 2017

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14 September 2017

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Trastuzumab: a novel standard option for patients with HER-2-positive advanced gastric or gastro-oesophageal junction cancer

14 September 2017

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Overcoming resistance and restoring sensitivity to HER2-targeted therapies in breast cancer

14 September 2017

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HER2 as a Prognostic Marker in Gastric Cancer - A Systematic Analysis of Data from the Literature

14 September 2017

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Increased signalling of EGFR and IGF1R, and deregulation of PTEN/PI3K/Akt pathway are related with trastuzumab resistance in HER2 breast carcinomas.

14 September 2017

1 reference

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Effects of anti-VEGF on pharmacokinetics, biodistribution, and tumor penetration of trastuzumab in a preclinical breast cancer model.

14 September 2017

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Heterogeneous amplification of ERBB2 in primary lesions is responsible for the discordant ERBB2 status of primary and metastatic lesions in gastric carcinoma

14 September 2017

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Resistance to EGFR-targeted therapy: a family affair

14 September 2017

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IQGAP1 protein binds human epidermal growth factor receptor 2 (HER2) and modulates trastuzumab resistance

14 September 2017

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Evaluation of the association of PIK3CA mutations and PTEN loss with efficacy of trastuzumab therapy in metastatic breast cancer.

14 September 2017

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Combating trastuzumab resistance by targeting SRC, a common node downstream of multiple resistance pathways

14 September 2017

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Transcriptional and posttranslational up-regulation of HER3 (ErbB3) compensates for inhibition of the HER2 tyrosine kinase

14 September 2017

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IQGAP1 and IQGAP2 are reciprocally altered in hepatocellular carcinoma

14 September 2017

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PTEN, PIK3CA, p-AKT, and p-p70S6K status: association with trastuzumab response and survival in patients with HER2-positive metastatic breast cancer.

14 September 2017

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Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial

14 September 2017

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14 September 2017

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14 September 2017

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14 September 2017

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14 September 2017

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14 September 2017

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14 September 2017

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Mechanism of activation and inhibition of the HER4/ErbB4 kinase

14 September 2017

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Proteomic analysis of laser-captured paraffin-embedded tissues: a molecular portrait of head and neck cancer progression.

14 September 2017

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Surface comparison of active and inactive protein kinases identifies a conserved activation mechanism

14 September 2017

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Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancer

14 September 2017

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Mechanisms of disease: understanding resistance to HER2-targeted therapy in human breast cancer

14 September 2017

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The ErbB receptors and their ligands in cancer: an overview.

14 September 2017

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Treatment of metastatic esophagus and gastric cancer

14 September 2017

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Systemic treatment of gastric cancer.

14 September 2017

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The two histological main types of gastric carcinoma: diffuse and so called intestinal-type carcinoma: an attempt at a histo-clinical classification

14 September 2017

1 reference

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MAP kinases and CDKs: kinetic basis for catalytic activation

14 September 2017

1 reference

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Activation loop phosphorylation and catalysis in protein kinases: is there functional evidence for the autoinhibitor model?

14 September 2017

1 reference

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Mechanism of action of trastuzumab and scientific update

14 September 2017

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ErbB2 potentiates breast tumor proliferation through modulation of p27(Kip1)-Cdk2 complex formation: receptor overexpression does not determine growth dependency

14 September 2017

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Nonclinical studies addressing the mechanism of action of trastuzumab (Herceptin).

14 September 2017

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Different genome organization in two new cell lines established from human gastric carcinoma.

14 September 2017

1 reference

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Randomized phase III trial of fluorouracil alone versus fluorouracil plus cisplatin versus uracil and tegafur plus mitomycin in patients with unresectable, advanced gastric cancer: The Japan Clinical Oncology Group Study (JCOG9205).

14 September 2017

1 reference

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Identification of cadherin-11 down-regulation as a common response of astrocytoma cells to transforming growth factor-alpha

29 September 2017

1 reference

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Effects of oncogenic ErbB2 on G1 cell cycle regulators in breast tumour cells

29 September 2017

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Molecular genetics and in vitro sensitivity of a new human cell line, KKP, from a gastric adenocarcinoma.

29 September 2017

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Protein expression of HER2, 3, 4 in gastric cancer: correlation with clinical features and survival.

29 September 2017

1 reference

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SLUG silencing increases radiosensitivity of melanoma cells in vitro.

3 September 2018

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Prognostic significance of c-erbB2 overexpression in patients with metastatic gastric cancer

3 September 2018

1 reference

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HER-2 amplification is highly homogenous in gastric cancer.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4951299

Comparison of HER2 gene amplification assessed by fluorescence in situ hybridization and HER2 protein expression assessed by immunohistochemistry in gastric cancer.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4951299

Early HER2 dysregulation in gastric and oesophageal carcinogenesis

3 September 2018

1 reference

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Paclitaxel enhances in vitro radiosensitivity of squamous carcinoma cell lines of the head and neck

4 December 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26919099

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The prognostic significance of HER2 positivity for advanced gastric cancer patients undergoing first-line modified FOLFOX-6 regimen

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26919099

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Combined analysis of Rac1, IQGAP1, Tiam1 and E-cadherin expression in gastric cancer

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26919099

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.18632/ONCOTARGET.7575

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26919099%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26919099%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

1 reference