Structure and catalytic properties of carboxylesterase isozymes involved in metabolic activation of prodrugs (Q37096508)

18 August 2017

2 references

6 August 2019

28 September 2019

Structure and catalytic properties of carboxylesterase isozymes involved in metabolic activation of prodrugs (English)

1 reference

pharmaceutical preparation

18 August 2017

1 reference

6 August 2019

1 reference

28 September 2019

Masakiyo Hosokawa

1

1 reference

PubMed ID

18305428

18 August 2017

language of work or name

English

0 references

publication date

18 February 2008

3 references

18 August 2017

6 August 2019

28 September 2019

3 references

18 August 2017

6 August 2019

28 September 2019

13

1 reference

18 August 2017

2

1 reference

18 August 2017

412-431

1 reference

Creative Commons Attribution 4.0 International

18 August 2017

start time

18 February 2008

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

Identification of di-(2-ethylhexyl) phthalate-induced carboxylesterase 1 in C57BL/6 mouse liver microsomes: purification, cDNA cloning, and baculovirus-mediated expression

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13020412

Purification, molecular cloning, and functional expression of inducible liver acylcarnitine hydrolase in C57BL/6 mouse, belonging to the carboxylesterase multigene family

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13020412

Characterization of molecular species of liver microsomal carboxylesterases of several animal species and humans

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13020412

Purification, molecular cloning, and functional expression of dog liver microsomal acyl-CoA hydrolase: a member of the carboxylesterase multigene family

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13020412

Changes in carboxylesterase isoenzymes of rat liver microsomes during hepatocarcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13020412

Identity of purified monoacylglycerol lipase, palmitoyl-CoA hydrolase and aspirin-metabolizing carboxylesterase from rat liver microsomal fractions. A comparative study with enzymes purified in different laboratories

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13020412

Simultaneous purification and comparative characterization of six serine hydrolases from rat liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13020412

Hydrolysis of ester- and amide-type drugs by the purified isoenzymes of nonspecific carboxylesterase from rat liver.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13020412

Genomic structure and transcriptional regulation of the rat, mouse, and human carboxylesterase genes

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13020412

The mammalian carboxylesterases: from molecules to functions.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13020412

Structure, function and regulation of carboxylesterases

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13020412

Purification and characterization of a human liver cocaine carboxylesterase that catalyzes the production of benzoylecgonine and the formation of cocaethylene from alcohol and cocaine

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13020412

Cloning and sequencing of a novel murine liver carboxylesterase cDNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13020412

Glycosylation-dependent activity of baculovirus-expressed human liver carboxylesterases: cDNA cloning and characterization of two highly similar enzyme forms

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13020412

Differentiation-dependent expression of a human carboxylesterase in monocytic cells and transcription factor binding to the promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13020412

Purification and characterization of two rat liver microsomal carboxylesterases (hydrolase A and B).

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13020412

Rat testicular carboxylesterase: cloning, cellular localization, and relationship to liver hydrolase A.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13020412

Rat serum carboxylesterase. Cloning, expression, regulation, and evidence of secretion from liver

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13020412

Cloning and expression of hydrolase C, a member of the rat carboxylesterase family.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13020412

Substrate specificity of carboxylesterase isozymes and their contribution to hydrolase activity in human liver and small intestine

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13020412

Molecular cloning and characterization of a novel putative carboxylesterase, present in human intestine and liver

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13020412

Specific induction by glucocorticoids of steroid esterase in rat hepatic microsomes and its release into serum

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13020412

Particle size analysis of microcapsules

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13020412

Comparative chemical and immunological characterization of five lipolytic enzymes (carboxylesterases) from rat liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13020412

cDNA cloning, characterization and stable expression of novel human brain carboxylesterase

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13020412

Hydrolytic profile for ester- or amide-linkage by carboxylesterases pI 5.3 and 4.5 from human liver

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13020412

In vivo human carboxylesterase cDNA gene transfer to activate the prodrug CPT-11 for local treatment of solid tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13020412

Metabolic activation of CPT-11, 7-ethyl-10-[4-(1-piperidino)-1- piperidino]carbonyloxycamptothecin, a novel antitumor agent, by carboxylesterase

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13020412

Identification of the cytosolic carboxylesterase catalyzing the 5'-deoxy-5-fluorocytidine formation from capecitabine in human liver

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13020412

Evidence for the involvement of a pulmonary first-pass effect via carboxylesterase in the disposition of a propranolol ester derivative after intravenous administration.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13020412

Intracellular conversion of irinotecan to its active form, SN-38, by native carboxylesterase in human non-small cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13020412

Purification and cloning of a broad substrate specificity human liver carboxylesterase that catalyzes the hydrolysis of cocaine and heroin

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13020412

The esterases: perspectives and problems

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13020412

Characterization of a murine cDNA encoding a member of the carboxylesterase multigene family

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13020412

Biosynthesis of rat liver pI-6.1 esterase, a carboxylesterase of the cisternal space of the endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13020412

Nucleotide sequence of cDNA coding for rat liver pI 6.1 esterase (ES-10), a carboxylesterase located in the lumen of the endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13020412

Interleukin-6 alters the cellular responsiveness to clopidogrel, irinotecan, and oseltamivir by suppressing the expression of carboxylesterases HCE1 and HCE2.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13020412

Dexamethasone-induced methylprednisolone hemisuccinate hydrolase: its identification as a member of the rat carboxylesterase 2 family and its unique existence in plasma.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13020412

Cloning and sequence analysis of a hamster liver cDNA encoding a novel putative carboxylesterase

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13020412

Cloning and nucleotide sequence of a novel, male-predominant carboxylesterase in mouse liver

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13020412

Hydrolysis of irinotecan and its oxidative metabolites, 7-ethyl-10-[4-N-(5-aminopentanoic acid)-1-piperidino] carbonyloxycamptothecin and 7-ethyl-10-[4-(1-piperidino)-1-amino]-carbonyloxycamptothecin, by human carboxylesterases CES1A1, CES2, [...]

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13020412

A major urinary protein of the domestic cat regulates the production of felinine, a putative pheromone precursor

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13020412

Purification and characterization of a human liver arylacetamide deacetylase

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13020412

The retention signal for soluble proteins of the endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13020412

Cloning and sequencing of rat liver carboxylesterase ES-3 (egasyn).

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13020412

Characterization and functional expression of a cDNA encoding egasyn (esterase-22): the endoplasmic reticulum-targeting protein of β-glucuronidase

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13020412

Molecular cloning and characterization of a human carboxylesterase gene

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13020412

Patterns of amino acids near signal-sequence cleavage sites

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13020412

Relationship between sequence conservation and three-dimensional structure in a large family of esterases, lipases, and related proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13020412

A low-barrier hydrogen bond in the catalytic triad of serine proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13020412

Structure-function analysis of human triacylglycerol hydrolase by site-directed mutagenesis: identification of the catalytic triad and a glycosylation site

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13020412

Structural insights into CPT-11 activation by mammalian carboxylesterases

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13020412

Structural basis of heroin and cocaine metabolism by a promiscuous human drug-processing enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13020412

21 January 2018

The lipase gene family

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13020412

Molecular cloning and expression of rat lung carboxylesterase and its potential role in the detoxification of organophosphorus compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13020412

Human carboxylesterase isozymes: catalytic properties and rational drug design

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13020412

Current progress on esterases: from molecular structure to function

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13020412

Methylphenidate is stereoselectively hydrolyzed by human carboxylesterase CES1A1.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13020412

Anti-influenza prodrug oseltamivir is activated by carboxylesterase human carboxylesterase 1, and the activation is inhibited by antiplatelet agent clopidogrel.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13020412

Structural organization and characterization of the promoter region of a human carboxylesterase gene

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13020412

Synergistic role of specificity proteins and upstream stimulatory factor 1 in transactivation of the mouse carboxylesterase 2/microsomal acylcarnitine hydrolase gene promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13020412

Hepatocyte nuclear factor-4alpha plays pivotal roles in the regulation of mouse carboxylesterase 2 gene transcription in mouse liver

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13020412

Structural organization and characterization of the regulatory element of the human carboxylesterase (CES1A1 and CES1A2) genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES13020412

Conversion of the CPT-11 metabolite APC to SN-38 by rabbit liver carboxylesterase

21 January 2018

1 reference

12 December 2020

Intracellular movement of triacylglycerols in the intestine.

1 reference

12 December 2020

Carboxylesterases expressed in human colon tumor tissue and their role in CPT-11 hydrolysis

1 reference

12 December 2020

Species-, sex-, and age-dependent urinary excretion of cauxin, a mammalian carboxylesterase

1 reference

12 December 2020

Rat kidney carboxylesterase. Cloning, sequencing, cellular localization, and relationship to rat liver hydrolase

1 reference

12 December 2020

Purification and characterization of a novel 46.5-kilodalton esterase from mouse hepatic microsomes

1 reference

12 December 2020

Complete covalent structure of 60-kDa esterase isolated from 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced rabbit liver microsomes

1 reference

12 December 2020

Cloning and sequencing of rat liver carboxylesterase ES-4 (microsomal palmitoyl-CoA hydrolase)

1 reference

12 December 2020

A single nucleotide polymorphism in the carboxylesterase gene is associated with the responsiveness to imidapril medication and the promoter activity

1 reference

12 December 2020

Human liver arylacetamide deacetylase. Molecular cloning of a novel esterase involved in the metabolic activation of arylamine carcinogens with high sequence similarity to hormone-sensitive lipase

1 reference

12 December 2020

Binding and hydrolysis of meperidine by human liver carboxylesterase hCE-1

1 reference

12 December 2020

Overexpression of a rabbit liver carboxylesterase sensitizes human tumor cells to CPT-11

1 reference

12 December 2020

Comparative studies of drug-metabolizing enzymes in dog, monkey, and human small intestines, and in Caco-2 cells.

1 reference

12 December 2020

Variable activation of lovastatin by hydrolytic enzymes in human plasma and liver. 4

1 reference

12 December 2020

Crystal structure of human carboxylesterase 1 complexed with the Alzheimer's drug tacrine: from binding promiscuity to selective inhibition

1 reference

12 December 2020

cDNA cloning and characterization of human monocyte/macrophage serine esterase-1

1 reference

12 December 2020

Interindividual variation in carboxylesterase levels in human liver microsomes

1 reference

12 December 2020

Isolation and partial characterization of a cDNA encoding a rabbit liver carboxylesterase that activates the prodrug irinotecan (CPT-11).

1 reference

12 December 2020

Characterization of CPT-11 hydrolysis by human liver carboxylesterase isoforms hCE-1 and hCE-2

1 reference

12 December 2020

Differences in the induction of carboxylesterase isozymes in rat liver microsomes by perfluorinated fatty acids

1 reference

12 December 2020

Species differences in the induction of hepatic microsomal carboxylesterases caused by dietary exposure to di(2-ethylhexyl)phthalate, a peroxisome proliferator

1 reference

12 December 2020

Species difference and characterization of intestinal esterase on the hydrolizing activity of ester-type drugs

1 reference

12 December 2020

Human liver carboxylesterase hCE-1: binding specificity for cocaine, heroin, and their metabolites and analogs

1 reference

12 December 2020

Carboxylesterase in the liver and small intestine of experimental animals and human

1 reference

12 December 2020

Differences in the induction of carboxylesterase RL4 in rat liver microsomes by various perfluorinated fatty acids, metabolically inert derivatives of fatty acids

1 reference

12 December 2020

Metabolism of cocaine and heroin is catalyzed by the same human liver carboxylesterases

1 reference

12 December 2020

Purification and characterization of rhesus monkey liver amido hydrolases and their roles in the metabolic polymorphism for E6123, a platelet-activating factor receptor antagonist

1 reference

12 December 2020

Comprehensive evaluation of carboxylesterase-2 expression in normal human tissues using tissue array analysis.

1 reference

12 December 2020

Multiplicity and regulation of hepatic microsomal carboxylesterases in rats

1 reference

12 December 2020

Isolation, properties, and the complete amino acid sequence of a second form of 60-kDa glycoprotein esterase. Orientation of the 60-kDa proteins in the microsomal membrane

1 reference

12 December 2020

An accessory protein identical to mouse egasyn is complexed with rat microsomal beta-glucuronidase and is identical to rat esterase-3

1 reference

12 December 2020

The COOH terminus of several liver carboxylesterases targets these enzymes to the lumen of the endoplasmic reticulum.

1 reference

12 December 2020

Purification of an acyl-CoA hydrolase from rat intestinal microsomes. A candidate acyl-enzyme intermediate in glycerolipid acylation

1 reference

12 December 2020

10.3390/MOLECULES13020412

Identifiers

DOI

1 reference

18 August 2017

0 references

1 reference

PubMed ID

18305428