Dendritic cells and epithelial cells: linking innate and adaptive immunity in asthma (Q37095243)

18 August 2017

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title

Dendritic cells and epithelial cells: linking innate and adaptive immunity in asthma (English)

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18 August 2017

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Hamida Hammad

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Bart Lambrecht

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2

object named as

Bart N Lambrecht

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18 August 2017

1 March 2008

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Nature Reviews Immunology

18 August 2017

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18 August 2017

8

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18 August 2017

193-204

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18 August 2017

3

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The immunogenetics of asthma and eczema: a new focus on the epithelium

18 August 2017

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The role of allergy in the development of asthma

31 March 2020

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Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma

31 March 2020

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The immunopathology of extrinsic (atopic) and intrinsic (non-atopic) asthma: more similarities than differences

31 March 2020

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Mast-cell infiltration of airway smooth muscle in asthma.

31 March 2020

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How much asthma is really attributable to atopy?

31 March 2020

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Discovering susceptibility genes for asthma and allergy

31 March 2020

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Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis

31 March 2020

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Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness

31 March 2020

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A protease-activated pathway underlying Th cell type 2 activation and allergic lung disease

31 March 2020

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Der p 1 facilitates transepithelial allergen delivery by disruption of tight junctions

31 March 2020

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House dust mite major allergens Der p 1 and Der p 5 activate human airway-derived epithelial cells by protease-dependent and protease-independent mechanisms

31 March 2020

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Th2 polarization by Der p 1--pulsed monocyte-derived dendritic cells is due to the allergic status of the donors

31 March 2020

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Der p 1-pulsed myeloid and plasmacytoid dendritic cells from house dust mite-sensitized allergic patients dysregulate the T cell response

31 March 2020

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Involvement of CCL18 in allergic asthma

31 March 2020

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House dust mite allergens induce proinflammatory cytokines from respiratory epithelial cells: the cysteine protease allergen, Der p 1, activates protease-activated receptor (PAR)-2 and inactivates PAR-1.

31 March 2020

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Accelerated antigen sampling and transport by airway mucosal dendritic cells following inhalation of a bacterial stimulus

31 March 2020

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Dynamic imaging of dendritic cell extension into the small bowel lumen in response to epithelial cell TLR engagement

31 March 2020

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A major lung CD103 (alphaE)-beta7 integrin-positive epithelial dendritic cell population expressing Langerin and tight junction proteins

31 March 2020

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Specific migratory dendritic cells rapidly transport antigen from the airways to the thoracic lymph nodes

31 March 2020

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Essential role of lung plasmacytoid dendritic cells in preventing asthmatic reactions to harmless inhaled antigen

31 March 2020

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Mouse respiratory tract dendritic cell subsets and the immunological fate of inhaled antigens

31 March 2020

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Induction of tolerance to innocuous inhaled antigen relies on a CCR7-dependent dendritic cell-mediated antigen transport to the bronchial lymph node

31 March 2020

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Modulation of dendritic cell trafficking to and from the airways

31 March 2020

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Lung dendritic cells rapidly mediate anthrax spore entry through the pulmonary route

31 March 2020

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Distinct dendritic cell populations sequentially present antigen to CD4 T cells and stimulate different aspects of cell-mediated immunity

31 March 2020

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Prostaglandin D2 inhibits airway dendritic cell migration and function in steady state conditions by selective activation of the D prostanoid receptor 1.

31 March 2020

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Pen ch 13 allergen induces secretion of mediators and degradation of occludin protein of human lung epithelial cells

31 March 2020

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Pollen proteolytic enzymes degrade tight junctions

31 March 2020

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Cockroach extract antigen increases bronchial airway epithelial permeability

31 March 2020

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Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung.

31 March 2020

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Cellular mechanisms of mainstream cigarette smoke-induced lung epithelial tight junction permeability changes in vitro

31 March 2020

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Serum clara cell protein: a sensitive biomarker of increased lung epithelium permeability caused by ambient ozone

31 March 2020

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Prolonged inhaled allergen exposure can induce persistent tolerance.

31 March 2020

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Tolerance induced by inhaled antigen involves CD4(+) T cells expressing membrane-bound TGF-beta and FOXP3.

31 March 2020

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Regulation of IgE responses to inhaled antigen in mice by antigen-specific gamma delta T cells

31 March 2020

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Modulation of inhaled antigen-induced IgE tolerance by ongoing Th2 responses in the lung.

31 March 2020

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Antigen-specific regulatory T cells develop via the ICOS-ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity

31 March 2020

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Inflammatory mediators are insufficient for full dendritic cell activation and promote expansion of CD4+ T cell populations lacking helper function

31 March 2020

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Dendritic cells in a mature age.

31 March 2020

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T cell fitness determined by signal strength

31 March 2020

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Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen

31 March 2020

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Plasmacytoid dendritic cells inhibit pulmonary immunopathology and promote clearance of respiratory syncytial virus

31 March 2020

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A regulatory role for the C5a anaphylatoxin in type 2 immunity in asthma

31 March 2020

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Plasmacytoid dendritic cells prime IL-10-producing T regulatory cells by inducible costimulator ligand

31 March 2020

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Characterization of a new subpopulation of mouse CD8alpha+ B220+ dendritic cells endowed with type 1 interferon production capacity and tolerogenic potential

31 March 2020

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Alloantigen-presenting plasmacytoid dendritic cells mediate tolerance to vascularized grafts.

31 March 2020

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Reverse signaling through GITR ligand enables dexamethasone to activate IDO in allergy

31 March 2020

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Lipopolysaccharide-enhanced, toll-like receptor 4-dependent T helper cell type 2 responses to inhaled antigen

31 March 2020

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MyD88-dependent induction of allergic Th2 responses to intranasal antigen.

31 March 2020

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Environmental exposure to endotoxin and its relation to asthma in school-age children

31 March 2020

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Bacterial lipopolysaccharide signaling through Toll-like receptor 4 suppresses asthma-like responses via nitric oxide synthase 2 activity.

31 March 2020

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A Polymorphism* in the 5' flanking region of the CD14 gene is associated with circulating soluble CD14 levels and with total serum immunoglobulin E.

31 March 2020

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Association between exposure to farming, allergies and genetic variation in CARD4/NOD1.

31 March 2020

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Aerosol-induced immunoglobulin (Ig)-E unresponsiveness to ovalbumin does not require CD8+ or T cell receptor (TCR)-gamma/delta+ T cells or interferon (IFN)-gamma in a murine model of allergen sensitization

31 March 2020

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A new mechanism regulating the initiation of allergic airway inflammation

31 March 2020

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The protease allergen Der p 1 cleaves cell surface DC-SIGN and DC-SIGNR: experimental analysis of in silico substrate identification and implications in allergic responses

31 March 2020

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The proteolytic activity of the major dust mite allergen Der p 1 conditions dendritic cells to produce less interleukin-12: allergen-induced Th2 bias determined at the dendritic cell level

31 March 2020

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TSLP-activated dendritic cells induce an inflammatory T helper type 2 cell response through OX40 ligand.

31 March 2020

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Inducible costimulator regulates Th2-mediated inflammation, but not Th2 differentiation, in a model of allergic airway disease

31 March 2020

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Pollen-associated phytoprostanes inhibit dendritic cell interleukin-12 production and augment T helper type 2 cell polarization

31 March 2020

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ROS generated by pollen NADPH oxidase provide a signal that augments antigen-induced allergic airway inflammation

31 March 2020

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Myeloid dendritic cells induce Th2 responses to inhaled antigen, leading to eosinophilic airway inflammation

31 March 2020

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Innate immune responses to environmental allergens

31 March 2020

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TLR3- and Th2 cytokine-dependent production of thymic stromal lymphopoietin in human airway epithelial cells

31 March 2020

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Regulation of dendritic cell recruitment into resting and inflamed airway epithelium: use of alternative chemokine receptors as a function of inducing stimulus

31 March 2020

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Inhibition of the immunosuppressive activity of resident pulmonary alveolar macrophages by granulocyte/macrophage colony-stimulating factor

31 March 2020

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Proteinase-activated receptor-2 promotes allergic sensitization to an inhaled antigen through a TNF-mediated pathway

31 March 2020

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Dendritic cell quiescence during systemic inflammation driven by LPS stimulation of radioresistant cells in vivo

31 March 2020

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Both hemopoietic and resident cells are required for MyD88-dependent pulmonary inflammatory response to inhaled endotoxin.

31 March 2020

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Asthmatic bronchial epithelium activated by the proteolytic allergen Der p 1 increases selective dendritic cell recruitment

31 March 2020

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Airway epithelial cells release MIP-3alpha/CCL20 in response to cytokines and ambient particulate matter.

31 March 2020

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Beta-defensins: linking innate and adaptive immunity through dendritic and T cell CCR6

31 March 2020

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Chemokine receptor CCR2 but not CCR5 or CCR6 mediates the increase in pulmonary dendritic cells during allergic airway inflammation.

31 March 2020

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TSLP: an epithelial cell cytokine that regulates T cell differentiation by conditioning dendritic cell maturation

31 March 2020

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TSLP: finally in the limelight

31 March 2020

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Maintenance and polarization of human TH2 central memory T cells by thymic stromal lymphopoietin-activated dendritic cells.

31 March 2020

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Induction of IL-4 expression in CD4(+) T cells by thymic stromal lymphopoietin

31 March 2020

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IL-25 augments type 2 immune responses by enhancing the expansion and functions of TSLP-DC-activated Th2 memory cells

31 March 2020

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Interleukin 25 promotes the initiation of proallergic type 2 responses.

31 March 2020

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Thymic stromal lymphopoietin is released by human epithelial cells in response to microbes, trauma, or inflammation and potently activates mast cells

31 March 2020

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Thymic stromal lymphopoietin as a key initiator of allergic airway inflammation in mice

31 March 2020

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A role for TSLP in the development of inflammation in an asthma model

31 March 2020

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Cutting Edge: Proinflammatory and Th2 cytokines synergize to induce thymic stromal lymphopoietin production by human skin keratinocytes

31 March 2020

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Inducible expression of the proallergic cytokine thymic stromal lymphopoietin in airway epithelial cells is controlled by NFkappaB

31 March 2020

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Thymic stromal lymphopoietin expression is increased in asthmatic airways and correlates with expression of Th2-attracting chemokines and disease severity

31 March 2020

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Association between genetic polymorphisms in the human interleukin-7 receptor ?-chain and inhalation allergy

31 March 2020

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GM-CSF transgene expression in the airway allows aerosolized ovalbumin to induce allergic sensitization in mice

31 March 2020

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Diesel exhaust particle-exposed human bronchial epithelial cells induce dendritic cell maturation.

31 March 2020

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Interaction of cigarette smoke and house dust mite allergens on inflammatory mediator release from primary cultures of human bronchial epithelial cells

31 March 2020

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Cryopyrin activates the inflammasome in response to toxins and ATP

31 March 2020

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Extracellular ATP triggers and maintains asthmatic airway inflammation by activating dendritic cells

31 March 2020

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Physiological regulation of ATP release at the apical surface of human airway epithelia

31 March 2020

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The requirement for platelets in allergen-induced late asthmatic airway obstruction. Eosinophil infiltration and heightened airway responsiveness in allergic rabbits

31 March 2020

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The role of platelets in the pathophysiology of asthma.

31 March 2020

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Osteopontin has a crucial role in allergic airway disease through regulation of dendritic cell subsets

31 March 2020

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Chitin induces accumulation in tissue of innate immune cells associated with allergy

31 March 2020

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Acidic mammalian chitinase in asthmatic Th2 inflammation and IL-13 pathway activation

31 March 2020

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Simvastatin promotes Th2-type responses through the induction of the chitinase family member Ym1 in dendritic cells

31 March 2020

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Diverse and potent chemokine production by lung CD11bhigh dendritic cells in homeostasis and in allergic lung inflammation

31 March 2020

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Allergen-induced accumulation of airway dendritic cells is supported by an increase in CD31(hi)Ly-6C(neg) bone marrow precursors in a mouse model of asthma

31 March 2020

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Rapid dendritic cell recruitment to the bronchial mucosa of patients with atopic asthma in response to local allergen challenge

31 March 2020

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In vivo depletion of lung CD11c+ dendritic cells during allergen challenge abrogates the characteristic features of asthma

31 March 2020

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Bidirectional interactions between antigen-bearing respiratory tract dendritic cells (DCs) and T cells precede the late phase reaction in experimental asthma: DC activation occurs in the airway mucosa but not in the lung parenchyma

31 March 2020

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Matrix metalloproteinase-9-mediated dendritic cell recruitment into the airways is a critical step in a mouse model of asthma.

31 March 2020

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Interleukin-17 is a negative regulator of established allergic asthma

31 March 2020

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Comparative roles of IL-4, IL-13, and IL-4Ralpha in dendritic cell maturation and CD4+ Th2 cell function.

31 March 2020

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Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma

31 March 2020

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Signal transducer and activator of transcription factor 6 (Stat6)-deficient mice are protected from antigen-induced airway hyperresponsiveness and mucus production

31 March 2020

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Down-regulation of E-cadherin in human bronchial epithelial cells leads to epidermal growth factor receptor-dependent Th2 cell-promoting activity.

31 March 2020

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Disruption of E-cadherin-mediated adhesion induces a functionally distinct pathway of dendritic cell maturation

31 March 2020

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Recent progress in the biology of airway dendritic cells and implications for understanding the regulation of asthmatic inflammation

31 March 2020

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Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function

31 March 2020

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Activation of the D prostanoid 1 receptor suppresses asthma by modulation of lung dendritic cell function and induction of regulatory T cells

31 March 2020

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Inhaled iloprost suppresses the cardinal features of asthma via inhibition of airway dendritic cell function

31 March 2020

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Prostaglandin I2 analogs inhibit proinflammatory cytokine production and T cell stimulatory function of dendritic cells

31 March 2020

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IL‐10 and TGF‐β cooperate in the regulatory T cell response to mucosal allergens in normal immunity and specific immunotherapy

31 March 2020

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Comparison of Der p1-specific antibody levels in children with allergic airway disease and healthy controls

31 March 2020

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Relation of CD4+CD25+ regulatory T-cell suppression of allergen-driven T-cell activation to atopic status and expression of allergic disease.

31 March 2020

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Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells

31 March 2020

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Asthma: an epidemic of dysregulated immunity

31 March 2020

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CD103- and CD103+ bronchial lymph node dendritic cells are specialized in presenting and cross-presenting innocuous antigen to CD4+ and CD8+ T cells

31 March 2020

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Distinct migrating and nonmigrating dendritic cell populations are involved in MHC class I-restricted antigen presentation after lung infection with virus

31 March 2020

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Anatomical location determines the distribution and function of dendritic cells and other APCs in the respiratory tract.

31 March 2020

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New insights into the role of the complement pathway in allergy and asthma

31 March 2020

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Activity profile of dust mite allergen extract using substrate libraries and functional proteomic microarrays

31 March 2020

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Der p I, a major allergen of the house dust mite, proteolytically cleaves the low-affinity receptor for human IgE (CD23).

31 March 2020

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Cockroach allergen extract stimulates protease-activated receptor-2 (PAR-2) expressed in mouse lung fibroblast

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRI2275

1 reference

18 August 2017

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PubMed ID

18301423