Translating molecular discoveries into new therapies for atherosclerosis (Q37089723)

18 August 2017

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title

Translating molecular discoveries into new therapies for atherosclerosis (English)

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18 August 2017

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Daniel J Rader

1

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PubMed ID

18288179

18 August 2017

Alan Daugherty

series ordinal

2

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PubMed ID

18288179

18 August 2017

language of work or name

English

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publication date

1 February 2008

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18 August 2017

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18 August 2017

451

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18 August 2017

904-913

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18 August 2017

7181

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https://scigraph.springernature.com/pub.10.1038/nature06796

18 August 2017

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cites work

Natural history and histological classification of atherosclerotic lesions: an update

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

https://api.crossref.org/works/10.1038%2FNATURE06796

1 reference

7 January 2021

LRP6 mutation in a family with early coronary disease and metabolic risk factors

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

Nonvalidation of reported genetic risk factors for acute coronary syndrome in a large-scale replication study

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

Mouse models for atherosclerosis and pharmaceutical modifiers.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

Autosomal recessive hypercholesterolemia caused by mutations in a putative LDL receptor adaptor protein

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

Mutations in PCSK9 cause autosomal dominant hypercholesterolemia

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

Novel putative SREBP and LXR target genes identified by microarray analysis in liver of cholesterol-fed mice

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

NARC-1/PCSK9 and its natural mutants: zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

Decreased plasma cholesterol and hypersensitivity to statins in mice lacking Pcsk9

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

Sequence variations in PCSK9, low LDL, and protection against coronary heart disease

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

Molecular biology of PCSK9: its role in LDL metabolism

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

Familial combined hyperlipidemia is associated with upstream transcription factor 1 (USF1).

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

Potent reduction of apolipoprotein B and low-density lipoprotein cholesterol by short-term administration of an antisense inhibitor of apolipoprotein B.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

Inhibition of microsomal triglyceride transfer protein in familial hypercholesterolemia

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https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

Molecular regulation of HDL metabolism and function: implications for novel therapies

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

Effect of recombinant ApoA-I Milano on coronary atherosclerosis in patients with acute coronary syndromes: a randomized controlled trial

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

Effects of reconstituted high-density lipoprotein infusions on coronary atherosclerosis: a randomized controlled trial

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

Effects of an inhibitor of cholesteryl ester transfer protein on HDL cholesterol

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https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

Effects of torcetrapib in patients at high risk for coronary events

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

Illuminating HDL--is it still a viable therapeutic target?

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

ABC1: connecting yellow tonsils, neuropathy, and very low HDL.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

ATP-binding cassette transporters G1 and G4 mediate cellular cholesterol efflux to high-density lipoproteins

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

Macrophage ABCA1 and ABCG1, but not SR-BI, promote macrophage reverse cholesterol transport in vivo

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

Synthetic LXR ligand inhibits the development of atherosclerosis in mice

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

Pharmacological activation of liver X receptors promotes reverse cholesterol transport in vivo.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

Macrophage liver X receptor is required for antiatherogenic activity of LXR agonists

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

Endothelial and antithrombotic actions of HDL.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

Antiinflammatory properties of HDL.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

In vivo protection against endotoxin by plasma high density lipoprotein

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https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

Human high density lipoproteins are platforms for the assembly of multi-component innate immune complexes

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https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

Shotgun proteomics implicates protease inhibition and complement activation in the antiinflammatory properties of HDL

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

Apolipoprotein A-I mimetic peptides and their role in atherosclerosis prevention

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

Biological basis for the cardiovascular consequences of COX-2 inhibition: therapeutic challenges and opportunities

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

Roles of thromboxane A(2) and prostacyclin in the development of atherosclerosis in apoE-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

COX-2-derived prostacyclin confers atheroprotection on female mice

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

Deletion of microsomal prostaglandin E synthase-1 augments prostacyclin and retards atherogenesis.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

Antagonism of the prostaglandin D2 receptor 1 suppresses nicotinic acid-induced vasodilation in mice and humans

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

Leukotriene modifiers as potential therapeutics for cardiovascular disease

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

Expression of 5-lipoxygenase and leukotriene A4 hydrolase in human atherosclerotic lesions correlates with symptoms of plaque instability

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

Arachidonate 5-lipoxygenase promoter genotype, dietary arachidonic acid, and atherosclerosis

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

A variant of the gene encoding leukotriene A4 hydrolase confers ethnicity-specific risk of myocardial infarction

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

Identification of 5-lipoxygenase as a major gene contributing to atherosclerosis susceptibility in mice

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

The 5-lipoxygenase pathway promotes pathogenesis of hyperlipidemia-dependent aortic aneurysm.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

Effects of a 5-lipoxygenase-activating protein inhibitor on biomarkers associated with risk of myocardial infarction: a randomized trial

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

The oxidation hypothesis of atherogenesis: the role of oxidized phospholipids and HDL.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

Myeloperoxidase and cardiovascular disease.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

Protein carbamylation links inflammation, smoking, uremia and atherogenesis.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

Secretory phospholipase A2 enzymes in atherogenesis

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

Role of lipoprotein-associated phospholipase A2 in atherosclerosis and its potential as a therapeutic target

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

Pneumococcal vaccination decreases atherosclerotic lesion formation: molecular mimicry between Streptococcus pneumoniae and oxidized LDL.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

IL-5 links adaptive and natural immunity specific for epitopes of oxidized LDL and protects from atherosclerosis

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

Oxidized phospholipids, Lp(a) lipoprotein, and coronary artery disease

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

Angiotensin II promotes atherosclerotic lesions and aneurysms in apolipoprotein E-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

Angiotensin II-induced hypertension accelerates the development of atherosclerosis in apoE-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

Atherosclerosis and arterial blood pressure in mice

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

Getting to the site of inflammation: the leukocyte adhesion cascade updated

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

A major role for VCAM-1, but not ICAM-1, in early atherosclerosis

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

The adhesion receptor CD44 promotes atherosclerosis by mediating inflammatory cell recruitment and vascular cell activation

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

Endothelial mechanisms of flow-mediated athero-protection and susceptibility

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

Integration of flow-dependent endothelial phenotypes by Kruppel-like factor 2

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

Ly-6Chi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromata

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

Monocyte subsets differentially employ CCR2, CCR5, and CX3CR1 to accumulate within atherosclerotic plaques

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

Macrophage heterogeneity and tissue lipids

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https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

Macrophage activation and polarization

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https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein E

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

Modulation of atherosclerosis in mice by Toll-like receptor 2

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https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

Reduced atherosclerosis in MyD88-null mice links elevated serum cholesterol levels to activation of innate immunity signaling pathways

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

Toll-like receptor signaling and atherosclerosis

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

Mechanisms of disease: Toll-like receptors in cardiovascular disease

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

Thematic review series: the immune system and atherogenesis. The unusual suspects:an overview of the minor leukocyte populations in atherosclerosis.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

Inflammation, atherosclerosis, and coronary artery disease

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

Mast cells: multipotent local effector cells in atherothrombosis

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

Platelet activation and atherothrombosis

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

Emigration of monocyte-derived cells from atherosclerotic lesions characterizes regressive, but not progressive, plaques

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

Gene expression changes in foam cells and the role of chemokine receptor CCR7 during atherosclerosis regression in ApoE-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

Vascular repair by circulating endothelial progenitor cells: the missing link in atherosclerosis?

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

Hematopoietic stem cells differentiate into vascular cells that participate in the pathogenesis of atherosclerosis

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

Smooth muscle cells in atherosclerosis originate from the local vessel wall and not circulating progenitor cells in ApoE knockout mice.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

Lessons from sudden coronary death: a comprehensive morphological classification scheme for atherosclerotic lesions

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

Plaque rupture in humans and mice

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

Defining and defending murine models of plaque rupture

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

Loss of SR-BI expression leads to the early onset of occlusive atherosclerotic coronary artery disease, spontaneous myocardial infarctions, severe cardiac dysfunction, and premature death in apolipoprotein E-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

Dual role of matrix metalloproteinases (matrixins) in intimal thickening and atherosclerotic plaque rupture

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

Macrophage expression of active MMP-9 induces acute plaque disruption in apoE-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

Lysosomal cysteine proteases in atherosclerosis

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https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

Consequences and therapeutic implications of macrophage apoptosis in atherosclerosis: the importance of lesion stage and phagocytic efficiency

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

Combinatorial pattern recognition receptor signaling alters the balance of life and death in macrophages.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

Apoptosis of vascular smooth muscle cells induces features of plaque vulnerability in atherosclerosis.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

A common allele on chromosome 9 associated with coronary heart disease

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

A common variant on chromosome 9p21 affects the risk of myocardial infarction

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

Genomewide association analysis of coronary artery disease

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

TGF-beta and atherosclerosis in man.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

SDF-1alpha-mediated tissue repair by stem cells: a promising tool in cardiovascular medicine?

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06796

7 January 2021

Identifiers

DOI

10.1038/NATURE06796

1 reference

18 August 2017

1 reference

PubMed ID

18288179