Embracing emerging paradigms of G protein-coupled receptor agonism and signaling to address airway smooth muscle pathobiology in asthma (Q37085763)

18 August 2017

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title

Embracing emerging paradigms of G protein-coupled receptor agonism and signaling to address airway smooth muscle pathobiology in asthma (English)

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G protein-coupled receptor

18 August 2017

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asthma

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author name string

Raymond B Penn

series ordinal

1

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18 August 2017

16 February 2008

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18 August 2017

21

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Naunyn-Schmiedeberg's Archives of Pharmacology

inferred from page(s)

published in

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18 August 2017

378

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18 August 2017

2

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18 August 2017

149-169

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https://scigraph.springernature.com/pub.10.1007/s00210-008-0263-1

18 August 2017

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The mAKAP complex participates in the induction of cardiac myocyte hypertrophy by adrenergic receptor signaling

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Expression of a beta-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice

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Theophylline: mechanism of action and use in asthma and chronic obstructive pulmonary disease

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VIP inhibits basal and histamine-stimulated proliferation of human airway smooth muscle cells

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Absence of muscarinic cholinergic airway responses in mice deficient in the cyclic nucleotide phosphodiesterase PDE4D

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Receptors and pathways mediating the effects of prostaglandin E2 on airway tone

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Sphingosine 1-phosphate modulates human airway smooth muscle cell functions that promote inflammation and airway remodeling in asthma

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12 December 2020

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Airway smooth muscle: immunomodulatory cells?

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Beta-adrenoceptor blockade with propranolol and bronchial responsiveness to a number of bronchial provocation tests in non-asthmatic subjects

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Physiological effects of inverse agonists in transgenic mice with myocardial overexpression of the beta 2-adrenoceptor

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12 December 2020

Proliferative aspects of airway smooth muscle.

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12 December 2020

A-kinase anchoring proteins interact with phosphodiesterases in T lymphocyte cell lines

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12 December 2020

The endothelin subtype A receptor undergoes agonist- and antagonist-mediated internalization in the absence of signaling

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12 December 2020

AKAP proteins anchor cAMP-dependent protein kinase to KvLQT1/IsK channel complex

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12 December 2020

AKAP complex regulates Ca2+ re-uptake into heart sarcoplasmic reticulum

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12 December 2020

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12 December 2020

Inverse agonism of histamine H2 antagonist accounts for upregulation of spontaneously active histamine H2 receptors

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12 December 2020

Constitutively active mutants of rhodopsin

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12 December 2020

RNA editing of the human serotonin 5-hydroxytryptamine 2C receptor silences constitutive activity

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12 December 2020

GRKs and beta-arrestins: roles in receptor silencing, trafficking and signaling

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12 December 2020

Cloning and characterization of AKAP 95, a nuclear protein that associates with the regulatory subunit of type II cAMP-dependent protein kinase

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12 December 2020

Cutting edge: A-kinase anchor proteins are involved in maintaining resting T cells in an inactive state.

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12 December 2020

Molecular characterization of the cAMP-dependent protein kinase bound to microtubule-associated protein 2

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12 December 2020

mAKAP and the ryanodine receptor are part of a multi-component signaling complex on the cardiomyocyte nuclear envelope

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12 December 2020

Interferon-gamma modulates cysteinyl leukotriene receptor-1 expression and function in human airway myocytes

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12 December 2020

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12 December 2020

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12 December 2020

Inhibition of allergen-induced airway remodelling by tiotropium and budesonide: a comparison

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12 December 2020

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12 December 2020

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12 December 2020

A protein kinase bound to the projection portion of MAP 2 (microtubule-associated protein 2)

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12 December 2020

Novel brain-specific 5-HT4 receptor splice variants show marked constitutive activity: role of the C-terminal intracellular domain

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12 December 2020

CysLT1 receptor upregulation by TGF-β and IL-13 is associated with bronchial smooth muscle cell proliferation in response to LTD4

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12 December 2020

Critical role of cAMP-dependent protein kinase anchoring to the L-type calcium channel Cav1.2 via A-kinase anchor protein 150 in neurons.

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12 December 2020

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12 December 2020

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12 December 2020

Airway smooth muscle: a modulator of airway remodeling in asthma

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12 December 2020

Ryanodine receptors/calcium release channels in heart failure and sudden cardiac death

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12 December 2020

Phosphodiesterase inhibitors in airways disease

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

Effects of LTD4 on human airway smooth muscle cell proliferation, matrix expression, and contraction In vitro: differential sensitivity to cysteinyl leukotriene receptor antagonists

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12 December 2020

Cytokines regulate beta-2-adrenergic receptor responsiveness in airway smooth muscle via multiple PKA- and EP2 receptor-dependent mechanisms.

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12 December 2020

Independent beta-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2.

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12 December 2020

Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor

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12 December 2020

Versatility of GPCR recognition by drugs: from biological implications to therapeutic relevance

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12 December 2020

Antigen-specific CD4+ T cells drive airway smooth muscle remodeling in experimental asthma

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12 December 2020

beta-adrenoceptor mediated responses in rat pulmonary artery: putative role of TASK-1 related K channels.

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12 December 2020

Fluticasone inhibits but does not reverse allergen-induced structural airway changes

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12 December 2020

A constitutively activating mutation of the luteinizing hormone receptor in familial male precocious puberty

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12 December 2020

A major functional role for phosphodiesterase 4D5 in human airway smooth muscle cells.

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12 December 2020

Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists

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12 December 2020

Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP

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12 December 2020

Localization and upregulation of cysteinyl leukotriene-1 receptor in asthmatic bronchial mucosa

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12 December 2020

Reversal of allergen-induced airway remodeling by CysLT1 receptor blockade

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12 December 2020

Mechanisms of proliferation synergy by receptor tyrosine kinase and G protein-coupled receptor activation in human airway smooth muscle.

1 reference

12 December 2020

Targeting of Protein Kinase A by Muscle A Kinase-anchoring Protein (mAKAP) Regulates Phosphorylation and Function of the Skeletal Muscle Ryanodine Receptor

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12 December 2020

Functional selectivity of D2 receptor ligands in a Chinese hamster ovary hD2L cell line: evidence for induction of ligand-specific receptor states

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12 December 2020

Allosteric site in M2 acetylcholine receptors: evidence for a major conformational change upon binding of an orthosteric agonist instead of an antagonist

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12 December 2020

Differential activation of Gq/11 and Gi(3) proteins at 5-hydroxytryptamine(2C) receptors revealed by antibody capture assays: influence of receptor reserve and relationship to agonist-directed trafficking

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12 December 2020

Endothelin-1-induced potentiation of human airway smooth muscle proliferation: an ETA receptor-mediated phenomenon

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12 December 2020

Sustained activation of a G protein-coupled receptor via "anchored" agonist binding. Molecular localization of the salmeterol exosite within the 2-adrenergic receptor

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12 December 2020

Caveolae and sorting in the trans-Golgi network of epithelial cells

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12 December 2020

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12 December 2020

High-affinity binding of the regulatory subunit (RII) of cAMP-dependent protein kinase to microtubule-associated and other cellular proteins

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12 December 2020

Adenosine-induced bronchoconstriction and contraction of airway smooth muscle from allergic rabbits with late-phase airway obstruction: evidence for an inducible adenosine A1 receptor

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12 December 2020

AKAP-Lbc nucleates a protein kinase D activation scaffold

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12 December 2020

Novel concepts of neuropeptide-based drug therapy: vasoactive intestinal polypeptide and its receptors

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12 December 2020

Requirement of a macromolecular signaling complex for beta adrenergic receptor modulation of the KCNQ1-KCNE1 potassium channel

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12 December 2020

Constitutive arrestin-mediated desensitization of a human vasopressin receptor mutant associated with nephrogenic diabetes insipidus

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12 December 2020

Ligand-directed functional heterogeneity of histamine H1 receptors: novel dual-function ligands selectively activate and block H1-mediated phospholipase C and adenylyl cyclase signaling

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12 December 2020

Involvement of cysteinyl leukotrienes in airway smooth muscle cell DNA synthesis after repeated allergen exposure in sensitized Brown Norway rats

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12 December 2020

G-Protein-coupled receptor-associated A-kinase anchoring proteins: AKAP79 and AKAP250 (gravin).

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12 December 2020

Airway remodeling from bench to bedside: current perspectives

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12 December 2020

Somatic mutations in the thyrotropin receptor gene cause hyperfunctioning thyroid adenomas

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12 December 2020

Probing the beta2 adrenoceptor binding site with catechol reveals differences in binding and activation by agonists and partial agonists

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12 December 2020

Targeting G protein-coupled receptor signaling in asthma

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12 December 2020

Salmeterol-induced desensitization, internalization and phosphorylation of the human beta2-adrenoceptor

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12 December 2020

EP(2) receptor mediates bronchodilation by PGE(2) in mice.

1 reference

12 December 2020

The A-kinase anchor protein MAP2B and cAMP-dependent protein kinase are associated with class C L-type calcium channels in neurons.

1 reference

12 December 2020

Cooperative mitogenic signaling by G protein-coupled receptors and growth factors is dependent on G(q/11)

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12 December 2020

Mouse model of airway remodeling: strain differences

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12 December 2020

A-kinase anchoring proteins take shape

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12 December 2020

Paradoxical trafficking and regulation of 5-HT(2A) receptors by agonists and antagonists

1 reference

12 December 2020

Dynamic complexes of beta2-adrenergic receptors with protein kinases and phosphatases and the role of gravin

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12 December 2020

Prostaglandin E2 protects lower airways against bronchoconstriction

1 reference

12 December 2020

beta-Arrestin 1 and 2 differentially regulate heptahelical receptor signaling and trafficking

1 reference

12 December 2020

beta2-adrenergic receptor desensitization, internalization, and phosphorylation in response to full and partial agonists

1 reference

12 December 2020

A unique mechanism of beta-blocker action: carvedilol stimulates beta-arrestin signaling

1 reference

12 December 2020

Effects of acute and chronic administration of beta-adrenoceptor ligands on airway function in a murine model of asthma

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12 December 2020

Ezrin is a cyclic AMP-dependent protein kinase anchoring protein

1 reference

12 December 2020

beta -Arrestins regulate protease-activated receptor-1 desensitization but not internalization or Down-regulation

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12 December 2020

Membrane-bound protein kinase A inhibits smooth muscle cell proliferation in vitro and in vivo by amplifying cAMP-protein kinase A signals

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12 December 2020

Beta-adrenergic agonists regulate KCa channels in airway smooth muscle by cAMP-dependent and -independent mechanisms

1 reference

12 December 2020

Protective effects of tiotropium bromide in the progression of airway smooth muscle remodeling

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12 December 2020

Cellular and molecular mechanisms regulating airway smooth muscle proliferation and cell adhesion molecule expression

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12 December 2020

Coordination of three signaling enzymes by AKAP79, a mammalian scaffold protein

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12 December 2020

Antagonists with negative intrinsic activity at delta opioid receptors coupled to GTP-binding proteins

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12 December 2020

Salmeterol stimulation dissociates beta2-adrenergic receptor phosphorylation and internalization

1 reference

12 December 2020

Corticosteroids prevent myofibroblast accumulation and airway remodeling in mice

1 reference

12 December 2020

The myocardium-protective Gly-49 variant of the beta 1-adrenergic receptor exhibits constitutive activity and increased desensitization and down-regulation

1 reference

12 December 2020

Cooperative regulation of p70S6 kinase by receptor tyrosine kinases and G protein-coupled receptors augments airway smooth muscle growth

1 reference

12 December 2020

Inhibition of T cell activation by cyclic adenosine 5'-monophosphate requires lipid raft targeting of protein kinase A type I by the A-kinase anchoring protein ezrin

1 reference

12 December 2020

Effects of ciclesonide and fluticasone propionate on allergen-induced airway inflammation and remodeling features.

1 reference

12 December 2020

Airway remodeling contributes to the progressive loss of lung function in asthma: an overview

1 reference

12 December 2020

Mechanism of beta-adrenergic receptor desensitization in cardiac hypertrophy is increased beta-adrenergic receptor kinase

1 reference

12 December 2020

A constitutively active mutant PTH-PTHrP receptor in Jansen-type metaphyseal chondrodysplasia

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12 December 2020

Remodeling in asthma and chronic obstructive pulmonary disease

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12 December 2020

Unoccupied beta-adrenoceptor-induced adenylyl cyclase stimulation in turkey erythrocyte membranes

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12 December 2020

Repeated allergen inhalations induce DNA synthesis in airway smooth muscle and epithelial cells in vivo

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12 December 2020

Airway smooth muscle dynamics: a common pathway of airway obstruction in asthma

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12 December 2020

DNA antisense therapy for asthma in an animal model

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12 December 2020

Constitutive activity of G protein coupled receptors and drug action

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12 December 2020

Changes in the carboxyl-terminal domain of metabotropic glutamate receptor 1 by alternative splicing generate receptors with differing agonist-independent activity.

1 reference

12 December 2020

10.1007/S00210-008-0263-1

Identifiers

DOI

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18 August 2017

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PubMed ID

18278482