Acat1 knockdown gene therapy decreases amyloid-β in a mouse model of Alzheimer's disease (Q37073099)

18 August 2017

Acat1 knockdown gene therapy decreases amyloid-β in a mouse model of Alzheimer's disease (English)

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18 August 2017

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5

Zachary Bowen

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18 August 2017

Stephanie R Murphy

1

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18 August 2017

Catherine Cy Chang

2

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18 August 2017

Godwin Dogbevia

3

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18 August 2017

Elena Y Bryleva

4

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18 August 2017

Mazahir T Hasan

6

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18 August 2017

Ta-Yuan Chang

7

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18 August 2017

18 June 2013

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18 August 2017

10

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inferred from page(s)

published in

Molecular Therapy

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18 August 2017

21

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18 August 2017

8

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18 August 2017

1497-1506

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describes a project that uses

18 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3734664/fullTextXML

inferred from PubMed Central ID database lookup

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Adeno-associated virus serotype 8 gene therapy leads to significant lowering of plasma cholesterol levels in humanized mouse models of homozygous and heterozygous familial hypercholesterolemia

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Abeta-directed single-chain antibody delivery via a serotype-1 AAV vector improves learning behavior and pathology in Alzheimer's disease mice

29 September 2017

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ACAT inhibition and amyloid beta reduction

29 September 2017

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29 September 2017

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29 September 2017

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ACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in mice with AD.

29 September 2017

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Inhibition of acyl-coenzyme A: cholesterol acyl transferase modulates amyloid precursor protein trafficking in the early secretory pathway

29 September 2017

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Laser-evoked synaptic transmission in cultured hippocampal neurons expressing channelrhodopsin-2 delivered by adeno-associated virus

29 September 2017

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29 September 2017

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29 September 2017

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Gene therapy using adeno-associated virus vectors

29 September 2017

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Next generation of adeno-associated virus 2 vectors: point mutations in tyrosines lead to high-efficiency transduction at lower doses

29 September 2017

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Artificial miRNAs mitigate shRNA-mediated toxicity in the brain: implications for the therapeutic development of RNAi

29 September 2017

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Specific AAV serotypes stably transduce primary hippocampal and cortical cultures with high efficiency and low toxicity

29 September 2017

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Alzheimer's disease: the lipid connection

29 September 2017

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Age-dependent sexual dimorphism in cognition and stress response in the 3xTg-AD mice

29 September 2017

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Silencing and un-silencing of tetracycline-controlled genes in neurons

29 September 2017

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Knockdown of ACAT-1 reduces amyloidogenic processing of APP

29 September 2017

1 reference

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Promoters and serotypes: targeting of adeno-associated virus vectors for gene transfer in the rat central nervous system in vitro and in vivo

29 September 2017

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Acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2) is induced in monocyte-derived macrophages: in vivo and in vitro studies

29 September 2017

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Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

29 September 2017

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Immunological quantitation and localization of ACAT-1 and ACAT-2 in human liver and small intestine

29 September 2017

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Recombinant acyl-CoA:cholesterol acyltransferase-1 (ACAT-1) purified to essential homogeneity utilizes cholesterol in mixed micelles or in vesicles in a highly cooperative manner

29 September 2017

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ACAT-2, a second mammalian acyl-CoA:cholesterol acyltransferase. Its cloning, expression, and characterization

29 September 2017

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Disruption of the acyl-CoA:cholesterol acyltransferase gene in mice: evidence suggesting multiple cholesterol esterification enzymes in mammals

29 September 2017

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29 September 2017

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29 September 2017

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27 June 2018

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27 June 2018

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Remodelling of the respiratory network in a mouse model of Rett syndrome depends on brain-derived neurotrophic factor regulated slow calcium buffering.

4 September 2018

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Adeno-associated viral (AAV) serotype 5 vector mediated gene delivery of endothelin-converting enzyme reduces Abeta deposits in APP + PS1 transgenic mice

4 September 2018

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Isolation and culture of adult neurons and neurospheres.

4 September 2018

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4 September 2018

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Effect of ACAT inhibition on the progression of coronary atherosclerosis

4 September 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3734664

Temporal profile of amyloid-beta (Abeta) oligomerization in an in vivo model of Alzheimer disease. A link between Abeta and tau pathology

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3734664

Tissue processing prior to protein analysis and amyloid-beta quantitation.

4 September 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3734664

Effects of the acyl coenzyme A:cholesterol acyltransferase inhibitor avasimibe on human atherosclerotic lesions

4 September 2018

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The ACAT inhibitor CP-113,818 markedly reduces amyloid pathology in a mouse model of Alzheimer's disease.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3734664

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4 September 2018

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12 December 2020

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Adeno-associated Viral (AAV) Serotype 5 Vector Mediated Gene Delivery of Endothelin-converting Enzyme Reduces Aβ Deposits in APP + PS1 Transgenic Mice

1 reference

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https://api.crossref.org/works/10.1038%2FMT.2013.118

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/MT.2013.118

1 reference

18 August 2017

1 reference

18 August 2017

1 reference