GEFs in growth factor signaling (Q37072597)

18 August 2017

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title

GEFs in growth factor signaling (English)

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18 August 2017

André Bernards

1

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18 August 2017

Jeffrey Settleman

series ordinal

2

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18 August 2017

publication date

1 October 2007

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18 August 2017

published in

Growth Factors Journal

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18 August 2017

volume

25

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18 August 2017

issue

5

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18 August 2017

page(s)

355-361

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Germline mutations in HRAS proto-oncogene cause Costello syndrome

18 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1080%2F08977190701830375

The Cool-2/alpha-Pix protein mediates a Cdc42-Rac signaling cascade

21 January 2018

1 reference

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Membrane translocation of P-Rex1 is mediated by G protein betagamma subunits and phosphoinositide 3-kinase

21 January 2018

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https://api.crossref.org/works/10.1080%2F08977190701830375

Ras superfamily and interacting proteins database.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190701830375

GAPs in growth factor signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190701830375

GEF-H1 modulates localized RhoA activation during cytokinesis under the control of mitotic kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190701830375

Identification of TRIO-GEFD1 chemical inhibitors using the yeast exchange assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190701830375

GEFs and GAPs: critical elements in the control of small G proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190701830375

The GTPase superfamily: a conserved switch for diverse cell functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190701830375

ELMOD2 is an Arl2 GTPase-activating protein that also acts on Arfs

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190701830375

Regulation of Sos activity by intramolecular interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190701830375

Vps9p CUE domain ubiquitin binding is required for efficient endocytic protein traffic

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190701830375

Ras binding triggers ubiquitination of the Ras exchange factor Ras-GRF2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190701830375

Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190701830375

Mutations in FGD4 encoding the Rho GDP/GTP exchange factor FRABIN cause autosomal recessive Charcot-Marie-Tooth type 4H

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190701830375

Phosphorylation of RhoGDI by Pak1 mediates dissociation of Rac GTPase

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190701830375

Ectopic expression of VAV1 reveals an unexpected role in pancreatic cancer tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190701830375

Cloning and characterization of mouse UBPy, a deubiquitinating enzyme that interacts with the ras guanine nucleotide exchange factor CDC25(Mm)/Ras-GRF1

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190701830375

Inhibition of cytohesins by SecinH3 leads to hepatic insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190701830375

Live-cell fluorescent biosensors for activated signaling proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190701830375

A mutation in the SOS1 gene causes hereditary gingival fibromatosis type 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190701830375

The FWD1/beta-TrCP-mediated degradation pathway establishes a 'turning off switch' of a Cdc42 guanine nucleotide exchange factor, FGD1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190701830375

Positional cloning uncovers mutations in PLCE1 responsible for a nephrotic syndrome variant that may be reversible

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190701830375

Drosophila TCTP is essential for growth and proliferation through regulation of dRheb GTPase

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190701830375

An autosomal dominant cerebellar ataxia linked to chromosome 16q22.1 is associated with a single-nucleotide substitution in the 5' untranslated region of the gene encoding a protein with spectrin repeat and Rho guanine-nucleotide exchange-factor dom

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190701830375

Turning on ARF: the Sec7 family of guanine-nucleotide-exchange factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190701830375

Regulation of proto-oncogenic dbl by chaperone-controlled, ubiquitin-mediated degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190701830375

Mutations in ARHGEF6, encoding a guanine nucleotide exchange factor for Rho GTPases, in patients with X-linked mental retardation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190701830375

Structural basis for ubiquitin recognition and autoubiquitination by Rabex-5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190701830375

Cbl-mediated ubiquitinylation and negative regulation of Vav.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190701830375

p27Kip1 Inhibition of GRB2-SOS Formation Can Regulate Ras Activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190701830375

Germline KRAS and BRAF mutations in cardio-facio-cutaneous syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190701830375

Phosphorylation of the cytokinesis regulator ECT2 at G2/M phase stimulates association of the mitotic kinase Plk1 and accumulation of GTP-bound RhoA

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190701830375

Gain-of-function RAF1 mutations cause Noonan and LEOPARD syndromes with hypertrophic cardiomyopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190701830375

Isolation and characterization of the faciogenital dysplasia (Aarskog-Scott syndrome) gene: a putative Rho/Rac guanine nucleotide exchange factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190701830375

Crystal structure of the ubiquitin binding domains of rabex-5 reveals two modes of interaction with ubiquitin

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190701830375

Polo-like Kinase 1 Triggers the Initiation of Cytokinesis in Human Cells by Promoting Recruitment of the RhoGEF Ect2 to the Central Spindle

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190701830375

Nedd4 regulates ubiquitination and stability of the guanine-nucleotide exchange factor CNrasGEF

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190701830375

Germline gain-of-function mutations in RAF1 cause Noonan syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190701830375

Expression of the Rho-GEF Pbl/ECT2 is regulated by the UBE3A E3 ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190701830375

Germline gain-of-function mutations in SOS1 cause Noonan syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190701830375

Germline mutations in genes within the MAPK pathway cause cardio-facio-cutaneous syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190701830375

Germline KRAS mutations cause Noonan syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190701830375

EPS8 and E3B1 transduce signals from Ras to Rac

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190701830375

Mutations in ARFGEF2 implicate vesicle trafficking in neural progenitor proliferation and migration in the human cerebral cortex

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190701830375

Structural analysis of autoinhibition in the Ras activator Son of sevenless

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190701830375

GAPex-5 mediates ubiquitination, trafficking, and degradation of epidermal growth factor receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190701830375

Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190701830375

Gain-of-function SOS1 mutations cause a distinctive form of Noonan syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190701830375

Insulin-stimulated disassociation of the SOS-Grb2 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190701830375

The mammalian guanine nucleotide exchange factor mSec12 is essential for activation of the Sar1 GTPase directing endoplasmic reticulum export

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190701830375

P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190701830375

Activated Cdc42 Sequesters c-Cbl and Prevents EGF Receptor Degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190701830375

DOCK4, a GTPase activator, is disrupted during tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190701830375

The gene encoding alsin, a protein with three guanine-nucleotide exchange factor domains, is mutated in a form of recessive amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190701830375

The Rab5 Activator ALS2/alsin Acts as a Novel Rac1 Effector through Rac1-activated Endocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190701830375

Inhibition by brefeldin A of a Golgi membrane enzyme that catalyses exchange of guanine nucleotide bound to ARF

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08977190701830375

10.1080/08977190701830375

21 January 2018

Identifiers

DOI

1 reference

18 August 2017

1 reference