Vaccination against self to prevent autoimmune disease: the type 1 diabetes model (Q37052632)

17 August 2017

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title

Vaccination against self to prevent autoimmune disease: the type 1 diabetes model (English)

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17 August 2017

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Leonard C Harrison

1

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17 August 2017

8 January 2008

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Immunology & Cell Biology

17 August 2017

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17 August 2017

86

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17 August 2017

2

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17 August 2017

139-145

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The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3

17 August 2017

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100151

Negative selection and autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100151

Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100151

Proinsulin is encoded by an RNA splice variant in human blood myeloid cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100151

Alternative splicing in disease and therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100151

Post-translational protein modifications in antigen recognition and autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100151

A sensitive method for detecting proliferation of rare autoantigen-specific human T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100151

The enemy within: keeping self-reactive T cells at bay in the periphery

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100151

Antigen-specific therapy for autoimmune disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100151

Risk assessment, prediction and prevention of type 1 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100151

Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100151

Intestinal permeability to mannitol and lactulose in children with type 1 diabetes with the HLA-DQB1*02 allele

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100151

Cow's milk and type 1 diabetes: the real debate is about mucosal immune function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100151

NOD mouse colonies around the world--recent facts and figures

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100151

Interactions between commensal intestinal bacteria and the immune system

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100151

TCR gamma delta intraepithelial lymphocytes are required for self-tolerance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100151

Insulin in human milk and the prevention of type 1 diabetes

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ICB.7100151

Proinsulin-a pathogenic autoantigen in type 1 diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100151

Hay fever, hygiene, and household size

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100151

Transfer of hematopoietic stem cells encoding autoantigen prevents autoimmune diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100151

Responses against islet antigens in NOD mice are prevented by tolerance to proinsulin but not IGRP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100151

Optimized autoantibody-based risk assessment in family members. Implications for future intervention trials

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100151

Effects of insulin in relatives of patients with type 1 diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100151

Insulin resistance is a risk factor for progression to type 1 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100151

The NOD mouse: a model of immune dysregulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100151

Understanding autoimmune diabetes: insights from mouse models.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100151

Suppression of diabetes in nonobese diabetic mice by oral administration of porcine insulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100151

Oral insulin for diabetes prevention in NOD mice: potentiation by enhancing Th2 cytokine expression in the gut through bacterial adjuvant

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100151

A cholera toxoid-insulin conjugate as an oral vaccine against spontaneous autoimmune diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100151

A plant-based cholera toxin B subunit-insulin fusion protein protects against the development of autoimmune diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100151

Aerosol insulin induces regulatory CD8 gamma delta T cells that prevent murine insulin-dependent diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100151

Gamma delta T cells as mediators of mucosal tolerance: the autoimmune diabetes model

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100151

Protection of nonobese diabetic mice from diabetes by intranasal or subcutaneous administration of insulin peptide B-(9-23)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100151

Nasal administration of glutamate decarboxylase (GAD65) peptides induces Th2 responses and prevents murine insulin-dependent diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100151

Induction of tolerance in autoimmune diseases by hematopoietic stem cell transplantation: getting closer to a cure?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100151

Chronic graft-versus-host disease: clinical manifestation and therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100151

A randomized trial of intensive insulin therapy in newly diagnosed insulin-dependent diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100151

Insulin prophylaxis in individuals at high risk of type I diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100151

Oral insulin administration and residual beta-cell function in recent-onset type 1 diabetes: a multicentre randomised controlled trial. Diabète Insuline Orale group.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100151

No effect of oral insulin on residual beta-cell function in recent-onset type I diabetes (the IMDIAB VII). IMDIAB Group.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100151

Mucosal Antigen Primes Diabetogenic Cytotoxic T-Lymphocytes Regardless of Dose or Delivery Route

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100151

Pancreatic beta-cell function and immune responses to insulin after administration of intranasal insulin to humans at risk for type 1 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100151

Immune deviation: a historical perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100151

Induction of Autoimmune Diabetes by Oral Administration of Autoantigen

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100151

Transient blockade of CD40 ligand dissociates pathogenic from protective mucosal immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100151

Double-blind pilot trial of oral tolerization with myelin antigens in multiple sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100151

Disabling an integral CTL epitope allows suppression of autoimmune diabetes by intranasal proinsulin peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100151

Oral tolerance: mechanisms and therapeutic applications.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100151

7 January 2021

HLA antigens and age at diagnosis of insulin-dependent diabetes mellitus

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100151

7 January 2021

Proliferative recruitment of intestinal intraepithelial lymphocytes after microbial colonization of germ-free mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100151

7 January 2021

Association between rotavirus infection and pancreatic islet autoimmunity in children at risk of developing type 1 diabetes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100151

7 January 2021

From vanilla to 28 flavors: multiple varieties of T regulatory cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100151

7 January 2021

Transgenic expression of mouse proinsulin II prevents diabetes in nonobese diabetic mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100151

7 January 2021

Prediction of type I diabetes in first-degree relatives using a combination of insulin, GAD, and ICA512bdc/IA-2 autoantibodies

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100151

7 January 2021

Islet autoimmunity in infants with a Type I diabetic relative is common but is frequently restricted to one autoantibody

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100151

7 January 2021

Oral administration of human insulin to NOD mice generates CD4+ T cells that suppress adoptive transfer of diabetes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100151

7 January 2021

Protection against autoimmune diabetes with oral insulin is associated with the presence of IL-4 type 2 T-cells in the pancreas and pancreatic lymph nodes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100151

7 January 2021

Mucosal administration of IL-10 enhances oral tolerance in autoimmune encephalomyelitis and diabetes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100151

7 January 2021

Oral administration of schistosome egg antigens and insulin B-chain generates and enhances Th2-type responses in NOD mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100151

7 January 2021

Oral administration of cholera toxin B-insulin conjugates protects NOD mice from autoimmune diabetes by inducing CD4+ regulatory T-cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100151

7 January 2021

Transgenic plants expressing autoantigens fed to mice to induce oral immune tolerance

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100151

7 January 2021

Oral administration of insulin to neonates suppresses spontaneous and cyclophosphamide induced diabetes in the NOD mouse

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100151

7 January 2021

Intranasal vaccination with proinsulin DNA induces regulatory CD4+ T cells that prevent experimental autoimmune diabetes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100151

7 January 2021

Evidence that a peptide spanning the B-C junction of proinsulin is an early Autoantigen epitope in the pathogenesis of type 1 diabetes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100151

7 January 2021

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100151

7 January 2021

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100151

7 January 2021

Autoimmune diabetes is suppressed by transfer of proinsulin-encoding Gr-1+ myeloid progenitor cells that differentiate in vivo into resting dendritic cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100151

7 January 2021

Inhibition of experimental autoimmune encephalomyelitis by inhalation but not oral administration of the encephalitogenic peptide: influence of MHC binding affinity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100151

7 January 2021

Suppression of the immune response by nasal immunization

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100151

7 January 2021

Effects of oral administration of type II collagen on rheumatoid arthritis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100151

7 January 2021

Lack of efficacy of oral bovine type II collagen added to existing therapy in rheumatoid arthritis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100151

7 January 2021

Identifiers

DOI

10.1038/SJ.ICB.7100151

1 reference

17 August 2017

1 reference

PubMed ID

18180798