Diaminothiazoles modify Tau phosphorylation and improve the tauopathy in mouse models (Q37048487)

17 August 2017

Diaminothiazoles modify Tau phosphorylation and improve the tauopathy in mouse models (English)

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17 August 2017

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8

Li-Huei Tsai

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17 August 2017

10

Kenneth S Kosik

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17 August 2017

4

Waltraud Mair

1 reference

17 August 2017

Xuemei Zhang

1

1 reference

17 August 2017

Israel Hernandez

2

1 reference

17 August 2017

Damien Rei

3

1 reference

17 August 2017

Joydev K Laha

5

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17 August 2017

Madison E Cornwell

6

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17 August 2017

Gregory D Cuny

7

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17 August 2017

Judith A J Steen

9

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17 August 2017

language of work or name

English

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publication date

4 June 2013

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17 August 2017

15

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Journal of Biological Chemistry

inferred from page(s)

published in

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17 August 2017

288

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17 August 2017

30

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17 August 2017

22042-22056

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describes a project that uses

17 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3724657/fullTextXML

inferred from PubMed Central ID database lookup

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29 September 2017

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Structure-activity relationship study of 2,4-diaminothiazoles as Cdk5/p25 kinase inhibitors

29 September 2017

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Silencing of CDK5 reduces neurofibrillary tangles in transgenic alzheimer's mice

29 September 2017

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Efficacy of small-molecule glycogen synthase kinase-3 inhibitors in the postnatal rat model of tau hyperphosphorylation

29 September 2017

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Cyclin-dependent kinase 5 governs learning and synaptic plasticity via control of NMDAR degradation

29 September 2017

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29 September 2017

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Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles

29 September 2017

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Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

29 September 2017

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29 September 2017

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Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice

29 September 2017

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DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

29 September 2017

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Fluoro-Jade: a novel fluorochrome for the sensitive and reliable histochemical localization of neuronal degeneration

29 September 2017

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p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5

29 September 2017

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A preparation of Alzheimer paired helical filaments that displays distinct tau proteins by polyacrylamide gel electrophoresis

29 September 2017

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Dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine in mice.

29 September 2017

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A68: a major subunit of paired helical filaments and derivatized forms of normal Tau.

27 June 2018

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Tau protein kinase I converts normal tau protein into A68-like component of paired helical filaments

27 June 2018

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Specific inhibition of p25/Cdk5 activity by the Cdk5 inhibitory peptide reduces neurodegeneration in vivo.

27 June 2018

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Cyclodextrins promote protein aggregation posing risks for therapeutic applications.

4 September 2018

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Challenges in the conduct of disease-modifying trials in AD: practical experience from a phase 2 trial of Tau-aggregation inhibitor therapy.

4 September 2018

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Cyclin-dependent protein kinase 5 primes microtubule-associated protein tau site-specifically for glycogen synthase kinase 3beta

4 September 2018

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Opposing roles of transient and prolonged expression of p25 in synaptic plasticity and hippocampus-dependent memory.

4 September 2018

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Defining Cdk5 ligand chemical space with small molecule inhibitors of tau phosphorylation.

4 September 2018

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Discovery and SAR of 2-aminothiazole inhibitors of cyclin-dependent kinase 5/p25 as a potential treatment for Alzheimer's disease

4 September 2018

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Cdk5 is a key factor in tau aggregation and tangle formation in vivo.

4 September 2018

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Brain proline-directed protein kinase phosphorylates tau on sites that are abnormally phosphorylated in tau associated with Alzheimer's paired helical filaments.

4 September 2018

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Identification of the 23 kDa subunit of tau protein kinase II as a putative activator of cdk5 in bovine brain.

4 September 2018

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A brain-specific activator of cyclin-dependent kinase 5.

4 September 2018

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Monoclonal antibody PHF-1 recognizes tau protein phosphorylated at serine residues 396 and 404.

4 September 2018

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Substrate specificity characterization of a cdc2-like protein kinase purified from bovine brain

4 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23737518

12 December 2020

inferred from PubMed ID database lookup

Selective lesions by manganese and extensive damage by iron after injection into rat striatum or hippocampus

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23737518

12 December 2020

inferred from PubMed ID database lookup

Hydrofluoric acid-treated tau PHF proteins display the same biochemical properties as normal tau

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23737518

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1074/JBC.M112.436402

1 reference

17 August 2017

1 reference

17 August 2017

1 reference