Targeted inhibition of cyclic AMP phosphodiesterase-4 promotes brain tumor regression (Q37041337)

17 August 2017

Targeted inhibition of cyclic AMP phosphodiesterase-4 promotes brain tumor regression (English)

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17 August 2017

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8

David Piwnica-Worms

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17 August 2017

Patricia Goldhoff

1

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17 August 2017

Nicole M Warrington

2

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17 August 2017

David D Limbrick

3

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17 August 2017

Andrew Hope

4

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17 August 2017

B Mark Woerner

5

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17 August 2017

Erin Jackson

6

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17 August 2017

Arie Perry

7

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17 August 2017

Joshua B Rubin

9

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17 August 2017

language of work or name

English

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publication date

1 December 2008

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17 August 2017

9

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inferred from page(s)

published in

Clinical Cancer Research

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17 August 2017

14

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17 August 2017

23

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17 August 2017

7717-7725

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describes a project that uses

17 August 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2615415/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Chemoresistant KM12C colon cancer cells are addicted to low cyclic AMP levels in a phosphodiesterase 4-regulated compartment via effects on phosphoinositide 3-kinase

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Blocking CXCR4-mediated cyclic AMP suppression inhibits brain tumor growth in vivo

29 September 2017

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Intracellular targeting of phosphodiesterase-4 underpins compartmentalized cAMP signaling

29 September 2017

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Cyclic nucleotide phosphodiesterases: molecular regulation to clinical use

29 September 2017

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Temozolomide-mediated radiation enhancement in glioblastoma: a report on underlying mechanisms

29 September 2017

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Malignant gliomas: strategies to increase the effectiveness of targeted molecular treatment

29 September 2017

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Abnormal expression of REST/NRSF and Myc in neural stem/progenitor cells causes cerebellar tumors by blocking neuronal differentiation

29 September 2017

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Keynote review: phosphodiesterase-4 as a therapeutic target

29 September 2017

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RNA silencing identifies PDE4D5 as the functionally relevant cAMP phosphodiesterase interacting with beta arrestin to control the protein kinase A/AKAP79-mediated switching of the beta2-adrenergic receptor to activation of ERK in HEK293B2 cells.

29 September 2017

1 reference

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MGMT gene silencing and benefit from temozolomide in glioblastoma

29 September 2017

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CXCR4 regulates growth of both primary and metastatic breast cancer

29 September 2017

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A small-molecule antagonist of CXCR4 inhibits intracranial growth of primary brain tumors.

29 September 2017

1 reference

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PDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalization

29 September 2017

1 reference

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The type IV phosphodiesterase inhibitor rolipram induces expression of the cell cycle inhibitors p21(Cip1) and p27(Kip1), resulting in growth inhibition, increased differentiation, and subsequent apoptosis of malignant A-172 glioma cells

29 September 2017

1 reference

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TAPAS-1, a novel microdomain within the unique N-terminal region of the PDE4A1 cAMP-specific phosphodiesterase that allows rapid, Ca2+-triggered membrane association with selectivity for interaction with phosphatidic acid

29 September 2017

1 reference

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Germline transmission and tissue-specific expression of transgenes delivered by lentiviral vectors

29 September 2017

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Cyclic 3',5'-nucleotide phosphodiesterases: potential targets for anticancer therapy

29 September 2017

1 reference

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Synthesis of 7-benzylamino-6-chloro-2-piperazino-4-pyrrolidinopteridine and novel derivatives free of positional isomers. Potent inhibitors of cAMP-specific phosphodiesterase and of malignant tumor cell growth.

29 September 2017

1 reference

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Identification and characterization of the human homologue of the short PDE4A cAMP-specific phosphodiesterase RD1 (PDE4A1) by analysis of the human HSPDE4A gene locus located at chromosome 19p13.2

29 September 2017

1 reference

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Cyclic AMP and adenyl cyclase in brain tumors

29 September 2017

1 reference

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Identification, characterization and regional distribution in brain of RPDE-6 (RNPDE4A5), a novel splice variant of the PDE4A cyclic AMP phosphodiesterase family

29 September 2017

1 reference

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In resting COS1 cells a dominant negative approach shows that specific, anchored PDE4 cAMP phosphodiesterase isoforms gate the activation, by basal cyclic AMP production, of AKAP-tethered protein kinase A type II located in the centrosomal region

29 September 2017

1 reference

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Chimeric constructs show that the unique N-terminal domain of the cyclic AMP phosphodiesterase RD1 (RNPDE4A1A; rPDE-IVA1) can confer membrane association upon the normally cytosolic protein chloramphenicol acetyltransferase

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2615415

Engineered deletion of the unique N-terminal domain of the cyclic AMP-specific phosphodiesterase RD1 prevents plasma membrane association and the attainment of enhanced thermostability without altering its sensitivity to inhibition by rolipram

27 June 2018

1 reference

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Cyclic nucleotides in experimental and human brain tumors

27 June 2018

1 reference

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Spatiotemporal differences in CXCL12 expression and cyclic AMP underlie the unique pattern of optic glioma growth in neurofibromatosis type 1.

27 June 2018

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Helix-1 of the cAMP-specific phosphodiesterase PDE4A1 regulates its phospholipase-D-dependent redistribution in response to release of Ca2+.

4 September 2018

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Widespread CXCR4 activation in astrocytomas revealed by phospho-CXCR4-specific antibodies

4 September 2018

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Mechanisms of rolipram-induced increase in the incidence of mammary adenocarcinoma: histopathological study of a 104-week oral carcinogenicity study in female Sprague-Dawley rats

4 September 2018

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Specific role of phosphodiesterase 4B in lipopolysaccharide-induced signaling in mouse macrophages

4 September 2018

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Chemotherapy for brain tumors--a new beginning.

4 September 2018

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The novel long PDE4A10 cyclic AMP phosphodiesterase shows a pattern of expression within brain that is distinct from the long PDE4A5 and short PDE4A1 isoforms

4 September 2018

1 reference

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Frequent co-alterations of TP53, p16/CDKN2A, p14ARF, PTEN tumor suppressor genes in human glioma cell lines

4 September 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2615415

Mutant p53 may selectively suppress glial specific proteins in pluripotential human neuroectodermal tumor cells

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2615415

Cranial radiation and concomitant cisplatin and mitomycin-C plus resistance modulators for malignant gliomas

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2615415

cAMP phosphodiesterase-4A1 (PDE4A1) has provided the paradigm for the intracellular targeting of phosphodiesterases, a process that underpins compartmentalized cAMP signalling

4 September 2018

1 reference

12 December 2020

Results of a phase II study of the antidepressant effect of rolipram

1 reference

12 December 2020

3',5'-Cyclic nucleotide phosphodiesterase in tumor cells as potential target for tumor growth inhibition

1 reference

12 December 2020

The effects of oral pentoxifylline on interleukin-2 toxicity in patients with metastatic renal cell carcinoma

1 reference

12 December 2020

Real-time imaging of ligand-induced IKK activation in intact cells and in living mice

1 reference

12 December 2020

10.1158/1078-0432.CCR-08-0827

Identifiers

DOI

1 reference

release_lq6guclnjre4vpdzmvgho5nkcu

17 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/lq6guclnjre4vpdzmvgho5nkcu

24 November 2022

mapped directly with Wikidata item

1 reference

17 August 2017

PubMed publication ID

19047098

1 reference