Chemical, Molecular Biology, and Genetic Techniques for Correlating DNA Base Damage Induced by Ionizing Radiation with Biological End Points (Q37040981)

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scientific article published on January 1, 1991

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English	Chemical, Molecular Biology, and Genetic Techniques for Correlating DNA Base Damage Induced by Ionizing Radiation with Biological End Points	scientific article published on January 1, 1991

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scholarly article

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Europe PubMed Central

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18 September 2019

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Chemical, molecular biology, and genetic techniques for correlating DNA base damage induced by ionizing radiation with biological end points (English)

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Europe PubMed Central

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18 September 2019

Chemical, Molecular Biology, and Genetic Techniques for Correlating DNA Base Damage Induced by Ionizing Radiation with Biological End Points (English)

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10.1007/978-1-4684-7627-9_17

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1 December 2022

molecular biology

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author name string

N. E. Geacintov

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C. E. Swenberg

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publication date

1 January 1991

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Basic Life Sciences

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453-73; discussion 473-4

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18 September 2019

Chemical changes induced in DNA by ionizing radiation.

2

1 reference

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DNA damage produced by ionizing radiation in mammalian cells: identities, mechanisms of formation, and reparability

3

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Site-specifically modified oligodeoxynucleotides as probes for the structural and biological effects of DNA-damaging agents

4

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Comparison of mechanisms for DNA strand break formation by the direct and indirect effect of radiation.

5

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The repair of double-strand DNA breaks correlates with radiosensitivity of L5178Y-S and L5178Y-R cells.

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Human epithelial teratocarcinoma cells (P3): radiobiological characterization, DNA damage, and comparison with other rodent and human cell lines.

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DNA double strand breaks in Ehrlich ascites tumour cells at low doses of x-rays. II. Can cell death be attributed to double strand breaks?

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The level of induced DNA double-strand breakage correlates with cell killing after X-irradiation

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Sites of gamma radiation-induced DNA strand breaks after alkali treatment

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Radiation-induced degradation of the base component in DNA and related substances--final products

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Radiation chemistry of a dinucleoside monophosphate and its sequence isomer

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Radiation damage to dinucleoside monophosphates: mediated versus direct damage

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Radiation chemistry of d(TpApCpG) in oxygenated solution

17

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DNA Repair in Bacteria and Mammalian Cells

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DNA Repair Enzymes

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Radiation-induced DNA damage and its repair.

20

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Quantitative determination of the 5-(hydroxymethyl)uracil moiety in the DNA of gamma-irradiated cells.

22

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Pyrimidine Dimer Induction inE. ColiDNA by Cerenkov Emission Associated with High Energy X-irradiation

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The formation of photoreactivable damage by direct excitation of DNA in X-irradiated E. coli cells

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Formation of an 8-hydroxyguanine moiety in deoxyribonucleic acid on gamma-irradiation in aqueous solution.

25

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Rate of depurination of native deoxyribonucleic acid

26

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Insertion of nucleotides opposite apurinic/apyrimidinic sites in deoxyribonucleic acid during in vitro synthesis: uniqueness of adenine nucleotides

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Infidelity of DNA synthesis associated with bypass of apurinic sites

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Mutagenesis by apurinic/apyrimidinic sites

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The biochemistry of mutagenesis

31

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[Genetic effects of low doses of radiation]

32

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The repairability of oxidative free radical mediated damage to DNA: a review

33

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DNA binding activity from cultured human fibrolasts that is specific for partially depurinated DNA and that inserts purines into apurinic sites

34

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Apurinic sites cause mutations in simian virus 40

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Depurination causes mutations in SOS-induced cells.

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Mutagenesis resulting from depurination is an SOS process

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Specificity of ionizing radiation-induced mutagenesis in the lac region of single-stranded phage M13 mp10 DNA.

38

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DNA sequencing with chain-terminating inhibitors

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Mutations induced by 60Co gamma-irradiation in double-stranded M13 bacteriophage DNA in nitrous-oxide saturated solutions are characterized by a high specificity

40

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60Co gamma-rays induce predominantly C/G to G/C transversions in double-stranded M13 DNA.

41

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Base substitutions, frameshifts, and small deletions constitute ionizing radiation-induced point mutations in mammalian cells

42

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Misreading of DNA templates containing 8-hydroxydeoxyguanosine at the modified base and at adjacent residues

44

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Determination of base sequence in nucleic acids with the electron microscope. V. The thymine-specific reactions of osmium tetroxide with deoxyribonucleic acid and its components

46

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Stepwise enzymic oligoribonucleotide synthesis including modified nucleotides

47

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T4 RNA ligase catalyzed synthesis of base analogue-containing oligodeoxyribonucleotides and a characterization of their thermal stabilities.

48

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Possible Relevance of O–6 Alkylation of Deoxyguanosine to the Mutagenicity and Carcinogenicity of Nitrosamines and Nitrosamides

49

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Conformational changes in the oligonucleotide duplex d(GCGTTGCG) x d(CGCAACGC) induced by formation of a cis-syn thymine dimer. A two-dimensional NMR study

51

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Genetic effects of thymine glycol: site-specific mutagenesis and molecular modeling studies

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Measurement of the radiosensitivity of a radiation-induced adenine defect in a single stranded DNA chain

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Repair deficient human disorders and cancer

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Apurinic sites as mutagenic intermediates

56

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DNA Glycosylases, Endonucleases for Apurinic/Apyrimidinic Sites, and Base Excision-Repair

57

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Thymine glycols and urea residues in M13 DNA constitute replicative blocks in vitro.

59

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Functional effects of cis-thymine glycol lesions on DNA synthesis in vitro

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Base-specific reactions useful for DNA sequencing: methylene blue – sensitized photooxidation of guanine and osmium tetraoxide modification of thymine

61

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57 Sequencing end-labeled DNA with base-specific chemical cleavages

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Sequence dependence for bypass of thymine glycols in DNA by DNA polymerase I

63

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cis-syn thymine dimers are not absolute blocks to replication by DNA polymerase I of Escherichia coli in vitro.

64

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Modeling and molecular mechanical studies of the cis-thymine glycol radiation damage lesion in DNA

65

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A review of some topics concerning mutagenesis by ultraviolet light

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UV mutagenic photoproducts in Escherichia coli and human cells: a molecular genetics perspective on human skin cancer.

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THE ULTRAVIOLET PHOTOCHEMISTRY OF THYMIDYLYL-(3'-5')-THYMIDINE

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Quantitative conversion of the (6-4) photoproduct of TpdC to its Dewar valence isomer upon exposure to simulated sunlight

72

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Solution-state structure of the Dewar pyrimidinone photoproduct of thymidylyl-(3'----5')-thymidine

73

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Synthesis of a trans-syn thymine dimer building block. Solid phase synthesis of CGTAT[t,s]TATGC.

74

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The structure of d(CGCGAAT[]TCGCG) . d(CGCGAATTCGCG); the incorporation of a thymine photodimer into a B-DNA helix

75

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Molecular models for DNA damaged by photoreaction

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Thymine dimers bend DNA

77

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Conformational features of DNA containing a cis-syn photodimer

78

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Cyclobutane pyrimidine dimers and (6-4) photoproducts block polymerization by DNA polymerase I.

80

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Influence of template strandedness on in vitro replication of mutagen-damaged DNA

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Site-specifically modified oligodeoxyribonucleotides as templates for Escherichia coli DNA polymerase I.

82

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Kinetic mechanism of DNA polymerase I (Klenow).

84

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Frequency and spectrum of mutations produced by a single cis-syn thymine-thymine cyclobutane dimer in a single-stranded vector

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Identifiers

10.1007/978-1-4684-7627-9_17

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Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:1811481%20AND%20SRC:MED&resulttype=core&format=json

18 September 2019

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Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:1811481%20AND%20SRC:MED&resulttype=core&format=json

18 September 2019

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