Processing of DNA damage clusters in human cells: current status of knowledge (Q37030594)

17 August 2017

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title

Processing of DNA damage clusters in human cells: current status of knowledge (English)

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17 August 2017

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Alexandros G Georgakilas

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1

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17 August 2017

7 November 2007

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17 August 2017

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17 August 2017

4

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17 August 2017

1

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17 August 2017

30-35

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Genomic instability in histologically normal breast tissues: implications for carcinogenesis

17 August 2017

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Cell-cycle checkpoints and cancer

21 January 2018

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Radical causes of cancer.

21 January 2018

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The complexity of DNA damage: relevance to biological consequences

21 January 2018

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Initial events in the cellular effects of ionizing radiations: clustered damage in DNA.

21 January 2018

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Clustered DNA damages induced in isolated DNA and in human cells by low doses of ionizing radiation

21 January 2018

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Clustered DNA damages induced by x rays in human cells

21 January 2018

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Processing of clustered DNA damage generates additional double-strand breaks in mammalian cells post-irradiation

21 January 2018

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A fast Monte Carlo algorithm to simulate the spectrum of DNA damages formed by ionizing radiation.

21 January 2018

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Monte carlo simulation of base and nucleotide excision repair of clustered DNA damage sites. II. Comparisons of model predictions to measured data

21 January 2018

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Processing of bistranded abasic DNA clusters in gamma-irradiated human hematopoietic cells

21 January 2018

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Two clustered 8-oxo-7,8-dihydroguanine (8-oxodG) lesions increase the point mutation frequency of 8-oxodG, but do not result in double strand breaks or deletions in Escherichia coli

21 January 2018

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Perpetuating radiation-induced chromosomal instability

21 January 2018

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Radiation-induced genomic instability in repair deficient mutants of Chinese hamster cells

21 January 2018

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Premature aging in mice deficient in DNA repair and transcription

21 January 2018

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Quality control by DNA repair

21 January 2018

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Securing genome stability by orchestrating DNA repair: removal of radiation-induced clustered lesions in DNA.

21 January 2018

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Reactivity of human apurinic/apyrimidinic endonuclease and Escherichia coli exonuclease III with bistranded abasic sites in DNA.

21 January 2018

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Oligonucleotides with bistranded abasic sites interfere with substrate binding and catalysis by human apurinic/apyrimidinic endonuclease

21 January 2018

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Efficiency of incision of an AP site within clustered DNA damage by the major human AP endonuclease

21 January 2018

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High efficiency detection of bi-stranded abasic clusters in gamma-irradiated DNA by putrescine

21 January 2018

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Processing of a complex multiply damaged DNA site by human cell extracts and purified repair proteins

21 January 2018

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An AP site can protect against the mutagenic potential of 8-oxoG when present within a tandem clustered site in E. coli.

21 January 2018

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Repair of tandem base lesions in DNA by human cell extracts generates persisting single-strand breaks

21 January 2018

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Dynamics and diversions in base excision DNA repair of oxidized abasic lesions

21 January 2018

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Targeted deletion of mNth1 reveals a novel DNA repair enzyme activity.

21 January 2018

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Substrate specificity of human endonuclease III (hNTH1). Effect of human APE1 on hNTH1 activity

21 January 2018

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AP endonuclease-independent DNA base excision repair in human cells

21 January 2018

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A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci.

21 January 2018

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Efficiency of excision of 8-oxo-guanine within DNA clustered damage by XRS5 nuclear extracts and purified human OGG1 protein

21 January 2018

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Interplay between DNA N-glycosylases/AP lyases at multiply damaged sites and biological consequences

21 January 2018

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Mode of inhibition of short-patch base excision repair by thymine glycol within clustered DNA lesions

21 January 2018

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DNA repair of clustered uracils in HeLa cells

21 January 2018

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Repair of uracil residues closely spaced on the opposite strands of plasmid DNA results in double-strand break and deletion formation.

21 January 2018

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Abortive base-excision repair of radiation-induced clustered DNA lesions in Escherichia coli

21 January 2018

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Attempted base excision repair of ionizing radiation damage in human lymphoblastoid cells produces lethal and mutagenic double strand breaks

21 January 2018

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Closely opposed apurinic/apyrimidinic sites are converted to double strand breaks in Escherichia coli even in the absence of exonuclease III, endonuclease IV, nucleotide excision repair and AP lyase cleavage

21 January 2018

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Accumulation of premutagenic DNA lesions in mice defective in removal of oxidative base damage

21 January 2018

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A method for detecting abasic sites in living cells: age-dependent changes in base excision repair

21 January 2018

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Endogenous DNA damage in humans: a review of quantitative data

21 January 2018

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Radiation-induced kidney injury: a role for chronic oxidative stress?

21 January 2018

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Molecular and cellular biology of moderate-dose (1-10 Gy) radiation and potential mechanisms of radiation protection: report of a workshop at Bethesda, Maryland, December 17-18, 2001.

21 January 2018

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Antioxidant role of N-acetyl cysteine isomers following high dose irradiation

21 January 2018

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In vivo formation and repair of DNA double-strand breaks after computed tomography examinations

21 January 2018

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Detection of oxidative clustered DNA lesions in X-irradiated mouse skin tissues and human MCF-7 breast cancer cells

21 January 2018

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Endogenous DNA damage clusters in human skin, 3-D model, and cultured skin cells

21 January 2018

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Assessment of oxidative base damage to isolated and cellular DNA by HPLC-MS/MS measurement

21 January 2018

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X-ray-induced oxidative stress: DNA damage and gene expression of HO-1, ERCC1 and OGG1 in mouse lung

21 January 2018

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Measurement of DNA base damage in cells exposed to low doses of gamma-radiation: comparison between the HPLC-EC and comet assays

21 January 2018

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Are we sure we know how to measure 8-oxo-7,8-dihydroguanine in DNA from human cells?

21 January 2018

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Low levels of clustered oxidative DNA damage induced at low and high LET irradiation in mammalian cells.

21 January 2018

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Induction and processing of complex DNA damage in human breast cancer cells MCF-7 and nonmalignant MCF-10A cells

21 January 2018

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Computational approach for determining the spectrum of DNA damage induced by ionizing radiation

21 January 2018

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21 January 2018

Identifiers

DOI

10.1039/B713178J

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17 August 2017

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PubMed ID

18075671