Diabetes models by screen for hyperglycemia in phenotype-driven ENU mouse mutagenesis projects (Q37023265)

17 August 2017

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title

Diabetes models by screen for hyperglycemia in phenotype-driven ENU mouse mutagenesis projects (English)

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17 August 2017

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Martin Hrabě de Angelis

4

Martin Hrabé de Angelis

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Nadja Herbach

Nadja Herbach

3

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Bernhard Aigner

Bernhard Aigner

1

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Rüdiger Wanke

Rüdiger Wanke

5

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Eckhard Wolf

Eckhard Wolf

6

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author name string

Birgit Rathkolb

2

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17 August 2017

4 December 2007

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American Journal of Physiology - Endocrinology and Metabolism

17 August 2017

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17 August 2017

294

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17 August 2017

2

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17 August 2017

E232-40

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Screening for increased plasma urea levels in a large-scale ENU mouse mutagenesis project reveals kidney disease models

17 August 2017

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https://api.crossref.org/works/10.1152%2FAJPENDO.00592.2007

Efficient and fast targeted production of murine models based on ENU mutagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00592.2007

Animal model for maturity-onset diabetes of the young generated by disruption of the mouse glucokinase gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00592.2007

Sequence-based analysis of mutagenized mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00592.2007

Uncovering the uncharacterized and unexpected: unbiased phenotype-driven screens in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00592.2007

The Collaborative Cross, a community resource for the genetic analysis of complex traits

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00592.2007

The genetic landscape of type 2 diabetes in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00592.2007

Mutation rate and predicted phenotypic target sizes in ethylnitrosourea-treated mice

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00592.2007

Nicotinamide nucleotide transhydrogenase: a key role in insulin secretion

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00592.2007

Introducing the German Mouse Clinic: open access platform for standardized phenotyping.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00592.2007

Glucokinase (GCK) mutations in hyper- and hypoglycemia: Maturity-onset diabetes of the young, permanent neonatal diabetes, and hyperinsulinemia of infancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00592.2007

Transgenic knockouts reveal a critical requirement for pancreatic beta cell glucokinase in maintaining glucose homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00592.2007

Dominant-Negative Effects of a Novel Mutated Ins2 Allele Causes Early-Onset Diabetes and Severe -Cell Loss in Munich Ins2C95S Mutant Mice

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00592.2007

Novel phenotypes identified by plasma biochemical screening in the mouse

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00592.2007

The use of genomewide ENU mutagenesis screens to unravel complex mammalian traits: identifying genes that regulate organ-specific and systemic autoimmunity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00592.2007

Genome-wide, large-scale production of mutant mice by ENU mutagenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00592.2007

A series of maturity onset diabetes of the young, type 2 (MODY2) mouse models generated by a large-scale ENU mutagenesis program

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00592.2007

Mapping of murine diabetogenic gene mody on chromosome 7 at D7Mit258 and its involvement in pancreatic islet and beta cell development during the perinatal period

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00592.2007

Estimating the number of coding mutations in genotypic and phenotypic driven N-ethyl-N-nitrosourea (ENU) screens: revisited.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00592.2007

Estimating the number of coding mutations in genotypic- and phenotypic-driven N-ethyl-N-nitrosourea (ENU) screens

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00592.2007

Genotype-specific environmental impact on the variance of blood values in inbred and F1 hybrid mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00592.2007

A role for Alström syndrome protein, alms1, in kidney ciliogenesis and cellular quiescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00592.2007

Obesity, hyperphagia and increased metabolic efficiency in Pc1 mutant mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00592.2007

Efficient gene-driven germ-line point mutagenesis of C57BL/6J mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00592.2007

Sim1 haploinsufficiency causes hyperphagia, obesity and reduction of the paraventricular nucleus of the hypothalamus

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00592.2007

Development of neuroendocrine lineages requires the bHLH-PAS transcription factor SIM1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00592.2007

Hypercholesterolemia in ENU-induced mouse mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00592.2007

A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00592.2007

21 January 2018

A mouse phenome project

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https://api.crossref.org/works/10.1152%2FAJPENDO.00592.2007

A gene-driven ENU-based approach to generating an allelic series in any gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00592.2007

The clinical-chemical screen in the Munich ENU Mouse Mutagenesis Project: screening for clinically relevant phenotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00592.2007

Random mutagenesis in the mouse as a tool in drug discovery

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00592.2007

Molecular characterization of ENU mouse mutagenesis and archives

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00592.2007

Gene-trap mutagenesis: past, present and beyond

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00592.2007

Lessons learned from molecular biology of insulin-gene mutations

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00592.2007

Insulin gene mutations as a cause of permanent neonatal diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00592.2007

A new mouse model of type 2 diabetes, produced by N-ethyl-nitrosourea mutagenesis, is the result of a missense mutation in the glucokinase gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00592.2007

A mutation in the insulin 2 gene induces diabetes with severe pancreatic beta-cell dysfunction in the Mody mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00592.2007

Global prevalence of diabetes: estimates for the year 2000 and projections for 2030

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00592.2007

Genome-wide genetic association of complex traits in heterogeneous stock mice

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00592.2007

10.1152/AJPENDO.00592.2007

21 January 2018

Identifiers

DOI

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17 August 2017

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PubMed ID

18056790