Dealing with uncertainties: ethics of prenatal diagnosis and preimplantation genetic diagnosis to prevent mitochondrial disorders (Q37023068)

17 August 2017

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title

Dealing with uncertainties: ethics of prenatal diagnosis and preimplantation genetic diagnosis to prevent mitochondrial disorders (English)

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17 August 2017

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Bredenoord AL

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17 August 2017

Pennings G

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2

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17 August 2017

Smeets HJ

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3

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17 August 2017

de Wert G

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4

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17 August 2017

language of work or name

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3 December 2007

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Human Reproduction Update

17 August 2017

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17 August 2017

14

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17 August 2017

83-94

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17 August 2017

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Reproductive freedom and risk.

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Preimplantation diagnosis for genetic susceptibility.

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Amplification of DNA sequences in polar bodies from human oocytes for diagnosis of mitochondrial disease.

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Biochemical-clinical correlation in patients with different loads of the mitochondrial DNA T8993G mutation

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MELAS and MERRF. The relationship between maternal mutation load and the frequency of clinically affected offspring.

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Epidemiology and treatment of mitochondrial disorders

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Inheritance of mitochondrial disorders

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Maternally inherited Leigh syndrome.

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Towards reliable prenatal diagnosis of mtDNA point mutations: studies of nt8993 mutations in oocytes, fetal tissues, children and adults

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Prospect of preimplantation genetic diagnosis for heritable mitochondrial DNA diseases.

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Beware! Preimplantation genetic diagnosis may solve some old problems but it also raises new ones.

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Preimplantation genetic diagnosis as medical innovation: reflections from The President's Council on Bioethics.

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Molecular-clinical correlations in a family with variable tissue mitochondrial DNA T8993G mutant load.

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Preimplantation genetic diagnosis principles and ethics.

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The continuing need for late abortions

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Transmission and prenatal diagnosis of the T9176C mitochondrial DNA mutation

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The transmission of OXPHOS disease and methods to prevent this

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Preimplantation genetic diagnosis and the 'new' eugenics

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Preimplantation genetic diagnosis in assisted reproduction.

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Personal desires of patients and social obligations of geneticists: applying preimplantation genetic diagnosis for non-medical sex selection

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Evolving ethics in medically assisted reproduction

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Progress in genetic counselling and prenatal diagnosis of maternally inherited mtDNA diseases

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Segregation of mitochondrial DNA (mtDNA) in human oocytes and in animal models of mtDNA disease: clinical implications.

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Prevention of human mitochondrial (mtDNA) disease by nucleus transplantation into an enucleated donor oocyte.

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Mitochondrial disease

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Preimplantation genetic diagnosis: the earliest form of prenatal diagnosis

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Rationale for banning abortions late in pregnancy.

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Analysis of mtDNA variant segregation during early human embryonic development: a tool for successful NARP preimplantation diagnosis

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Preimplantation genetic diagnosis: the ethics of intermediate cases.

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Genetic counseling and prenatal diagnosis for the mitochondrial DNA mutations at nucleotide 8993

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Mitochondrial DNA mutations at nucleotide 8993 show a lack of tissue- or age-related variation

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Risk of developing a mitochondrial DNA deletion disorder

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Identifiers

DOI

10.1093/HUMUPD/DMM037

1 reference

17 August 2017

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