Structure-Specific nuclease activities of Artemis and the Artemis: DNA-PKcs complex (Q37021606)

17 August 2017

Structure-Specific nuclease activities of Artemis and the Artemis: DNA-PKcs complex (English)

1 reference

17 August 2017

Howard H Y Chang

1

1 reference

PMCID

4914130

17 August 2017

Michael R Lieber

series ordinal

2

1 reference

PMCID

4914130

17 August 2017

language of work or name

English

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publication date

19 May 2016

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17 August 2017

7

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inferred from page(s)

published in

Nucleic Acids Research

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17 August 2017

44

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17 August 2017

11

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17 August 2017

4991-4997

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Creative Commons Attribution-NonCommercial 4.0 International

17 August 2017

start time

11 November 2016

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

Unifying the DNA end-processing roles of the artemis nuclease: Ku-dependent artemis resection at blunt DNA ends

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DNA repair. PAXX, a paralog of XRCC4 and XLF, interacts with Ku to promote DNA double-strand break repair

29 September 2017

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The spatial organization of non-homologous end joining: from bridging to end joining

29 September 2017

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Non-homologous end joining often uses microhomology: implications for alternative end joining

29 September 2017

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Endogenously induced DNA double strand breaks arise in heterochromatic DNA regions and require ataxia telangiectasia mutated and Artemis for their repair

29 September 2017

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Restoration of G1 chemo/radioresistance and double-strand-break repair proficiency by wild-type but not endonuclease-deficient Artemis

29 September 2017

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The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway

29 September 2017

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DNA-PKcs regulates a single-stranded DNA endonuclease activity of Artemis

29 September 2017

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DNA-PKcs deficiency in human: long predicted, finally found.

29 September 2017

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Impact of a hypomorphic Artemis disease allele on lymphocyte development, DNA end processing, and genome stability

29 September 2017

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DNA-PK: the means to justify the ends?

29 September 2017

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ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin

29 September 2017

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Coordinate 5' and 3' endonucleolytic trimming of terminally blocked blunt DNA double-strand break ends by Artemis nuclease and DNA-dependent protein kinase

29 September 2017

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Flexibility in the order of action and in the enzymology of the nuclease, polymerases, and ligase of vertebrate non-homologous DNA end joining: relevance to cancer, aging, and the immune system

29 September 2017

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DNA-PKcs dependence of Artemis endonucleolytic activity, differences between hairpins and 5' or 3' overhangs

29 September 2017

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DNA-PK autophosphorylation facilitates Artemis endonuclease activity

29 September 2017

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Biochemical mechanisms of chromosomal translocations resulting from DNA double-strand breaks

29 September 2017

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Terminal DNA structure and ATP influence binding parameters of the DNA-dependent protein kinase at an early step prior to DNA synapsis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4914130

XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining

29 September 2017

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Cernunnos, a novel nonhomologous end-joining factor, is mutated in human immunodeficiency with microcephaly

29 September 2017

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Repair of double-strand DNA breaks by the human nonhomologous DNA end joining pathway: the iterative processing model

29 September 2017

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The Artemis:DNA-PKcs endonuclease cleaves DNA loops, flaps, and gaps

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4914130

A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4914130

A biochemically defined system for mammalian nonhomologous DNA end joining

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4914130

Leaky Scid phenotype associated with defective V(D)J coding end processing in Artemis-deficient mice

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4914130

A founder mutation in Artemis, an SNM1-like protein, causes SCID in Athabascan-speaking Native Americans

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4914130

Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4914130

Productive and nonproductive complexes of Ku and DNA-dependent protein kinase at DNA termini

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4914130

Mechanistic constraints on diversity in human V(D)J recombination

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4914130

EBP-80, a transcription factor closely resembling the human autoantigen Ku, recognizes single- to double-strand transitions in DNA.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4914130

The primary immunodeficiencies

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4914130

Ku autoantigen is the regulatory component of a template-associated protein kinase that phosphorylates RNA polymerase II

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4914130

A non-leaky Artemis-deficient mouse that accurately models the human severe combined immune deficiency phenotype, including resistance to hematopoietic stem cell transplantation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4914130

Oral and genital ulceration: a unique presentation of immunodeficiency in Athabascan-speaking American Indian children with severe combined immunodeficiency

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4914130

Severe combined immunodeficiency among the Navajo. I. Characterization of phenotypes, epidemiology, and population genetics

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4914130

The nuclear serine/threonine protein kinase DNA-PK

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4914130

Distinct effects of DNA-PKcs and Artemis inactivation on signal joint formation in vivo

27 June 2018

1 reference

12 December 2020

Ku polypeptides synthesized in vitro assemble into complexes which recognize ends of double-stranded DNA

1 reference

12 December 2020

Mechanism of interaction between Ku protein and DNA

1 reference

12 December 2020

Human severe combined immunodeficiency: genetic, phenotypic, and functional diversity in one hundred eight infants

1 reference

12 December 2020

Identifiers

DOI

10.1093/NAR/GKW456

1 reference

17 August 2017

1 reference

17 August 2017

1 reference

PMCID

4914130