Pore-opening mechanism of the nicotinic acetylcholine receptor evinced by proton transfer (Q36999498)

17 August 2017

Pore-opening mechanism of the nicotinic acetylcholine receptor evinced by proton transfer (English)

1 reference

17 August 2017

Gisela D Cymes

1

1 reference

PMCID

2596065

17 August 2017

Claudio Grosman

series ordinal

2

1 reference

17 August 2017

30 March 2008

1 reference

Nature Structural & Molecular Biology

17 August 2017

1 reference

17 August 2017

15

1 reference

17 August 2017

4

1 reference

17 August 2017

389-396

1 reference

https://scigraph.springernature.com/pub.10.1038/nsmb.1407

17 August 2017

0 references

cites work

Nanosecond-timescale conformational dynamics of the human alpha7 nicotinic acetylcholine receptor

1 reference

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Neutralization of a single arginine residue gates open a two-pore domain, alkali-activated K+ channel

29 September 2017

1 reference

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Targeted molecular dynamics study of C-loop closure and channel gating in nicotinic receptors

29 September 2017

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Electrostatic properties of the mechanosensitive channel of small conductance MscS.

29 September 2017

1 reference

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Cholesterol interacts with transmembrane alpha-helices M1, M3, and M4 of the Torpedo nicotinic acetylcholine receptor: photolabeling studies using [3H]Azicholesterol

29 September 2017

1 reference

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Probing ion-channel pores one proton at a time

29 September 2017

1 reference

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An energy-efficient gating mechanism in the acetylcholine receptor channel suggested by molecular and Brownian dynamics

29 September 2017

1 reference

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Pore conformations and gating mechanism of a Cys-loop receptor

29 September 2017

1 reference

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The influence of amino acid protonation states on molecular dynamics simulations of the bacterial porin OmpF.

29 September 2017

1 reference

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Ion transport through membrane-spanning nanopores studied by molecular dynamics simulations and continuum electrostatics calculations

29 September 2017

1 reference

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A gating mechanism proposed from a simulation of a human alpha7 nicotinic acetylcholine receptor

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2596065

Refined structure of the nicotinic acetylcholine receptor at 4A resolution

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2596065

A twisted base? The role of arginine in enzyme-catalyzed proton abstractions.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2596065

Restoration of single-channel currents using the segmental k-means method based on hidden Markov modeling

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2596065

Structure and gating mechanism of the acetylcholine receptor pore

29 September 2017

1 reference

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Experimental pK(a) values of buried residues: analysis with continuum methods and role of water penetration

29 September 2017

1 reference

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What are the dielectric "constants" of proteins and how to validate electrostatic models?

29 September 2017

1 reference

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The extracellular linker of muscle acetylcholine receptor channels is a gating control element

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2596065

Asymmetric and independent contribution of the second transmembrane segment 12' residues to diliganded gating of acetylcholine receptor channels: a single-channel study with choline as the agonist

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2596065

HOLE: a program for the analysis of the pore dimensions of ion channel structural models

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2596065

New mutations in acetylcholine receptor subunit genes reveal heterogeneity in the slow-channel congenital myasthenic syndrome

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2596065

Estimating single-channel kinetic parameters from idealized patch-clamp data containing missed events

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2596065

Knowledge-based protein secondary structure assignment

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2596065

VMD: visual molecular dynamics

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2596065

Ion-channel gating. Twist to open.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2596065

Congenital myasthenic syndrome caused by prolonged acetylcholine receptor channel openings due to a mutation in the M2 domain of the epsilon subunit

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2596065

The permeability of the endplate channel to organic cations in frog muscle

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2596065

Structural and thermodynamic consequences of burying a charged residue within the hydrophobic core of T4 lysozyme

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2596065

Mutations in M2 alter the selectivity of the mouse nicotinic acetylcholine receptor for organic and alkali metal cations

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2596065

Closing in on the resting state of the Shaker K(+) channel.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2596065

A hydrophobic gate in an ion channel: the closed state of the nicotinic acetylcholine receptor

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2596065

State-dependent cross-linking of the M2 and M3 segments: functional basis for the alignment of GABAA and acetylcholine receptor M3 segments.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2596065

Functional effects of periodic tryptophan substitutions in the alpha M4 transmembrane domain of the Torpedo californica nicotinic acetylcholine receptor

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2596065

1H-NMR study on the tautomerism of the imidazole ring of histidine residues. I. Microscopic pK values and molar ratios of tautomers in histidine-containing peptides

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2596065

Desensitization of acetylcholine receptors in BC3H-1 cells

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2596065

Brownian dynamics investigation into the conductance state of the MscS channel crystal structure.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2596065

pK values of the ionizable groups of proteins

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2596065

Are acidic and basic groups in buried proteins predicted to be ionized?

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2596065

Gating-enhanced accessibility of hydrophobic sites within the transmembrane region of the nicotinic acetylcholine receptor's {delta}-subunit. A time-resolved photolabeling study

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2596065

Improved pKa calculations through flexibility based sampling of a water-dominated interaction scheme.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2596065

The role of hydrophobic microenvironments in modulating pKa shifts in proteins.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2596065

Calculations of enzymatic reactions: calculations of pKa, proton transfer reactions, and general acid catalysis reactions in enzymes.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2596065

Estimating the Dimension of a Model

4 September 2018

1 reference

Intrinsic Relative Stabilities of the Neutral Tautomers of Arginine Side-Chain Models

21 January 2018

1 reference

A Hydrophobic Gating Mechanism for Nanopores

21 January 2018

1 reference

Acetylcholine receptor channel imaged in the open state

21 January 2018

1 reference

Identifying the lipid-protein interface of the Torpedo nicotinic acetylcholine receptor: secondary structure implications

21 January 2018

1 reference

The influence of geometry, surface character, and flexibility on the permeation of ions and water through biological pores

31 March 2020

1 reference

Probing the structure of the nicotinic acetylcholine receptor with the hydrophobic photoreactive probes [125I]TID-BE and [125I]TIDPC/16

31 March 2020

1 reference

X-ray structure of a prokaryotic pentameric ligand-gated ion channel

31 March 2020

1 reference

Agonist-induced changes in the structure of the acetylcholine receptor M2 regions revealed by photoincorporation of an uncharged nicotinic noncompetitive antagonist

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18376414

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NSMB.1407

1 reference

PMCID

2596065

Dimensions Publication ID

17 August 2017

0 references

1 reference

17 August 2017

1 reference

PMCID

2596065