Mechanism-based inactivation of human cytochrome P450 enzymes: strategies for diagnosis and drug-drug interaction risk assessment (Q36985086)

17 August 2017

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title

Mechanism-based inactivation of human cytochrome P450 enzymes: strategies for diagnosis and drug-drug interaction risk assessment (English)

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17 August 2017

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Venkatakrishnan K

1

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17 August 2017

Obach RS

series ordinal

2

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17 August 2017

Rostami-Hodjegan A

series ordinal

3

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17 August 2017

language of work or name

English

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publication date

1 October 2007

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17 August 2017

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17 August 2017

volume

37

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17 August 2017

issue

10-11

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17 August 2017

page(s)

1225-1256

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The influence of nonspecific microsomal binding on apparent intrinsic clearance, and its prediction from physicochemical properties.

17 August 2017

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Prediction of plasma protein binding displacement and its implications for quantitative assessment of metabolic drug-drug interactions from in vitro data

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Mechanism-based inactivation of CYP3A by HIV protease inhibitors

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Time response of cytochrome P450 1A2 activity on cessation of heavy smoking

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Prediction of time-dependent CYP3A4 drug-drug interactions: impact of enzyme degradation, parallel elimination pathways, and intestinal inhibition

21 January 2018

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A critical evaluation of the experimental design of studies of mechanism based enzyme inhibition, with implications for in vitro-in vivo extrapolation

21 January 2018

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Time course of recovery of cytochrome p450 3A function after single doses of grapefruit juice

21 January 2018

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Substrate depletion approach for determining in vitro metabolic clearance: time dependencies in hepatocyte and microsomal incubations

21 January 2018

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Mechanism-based inactivation of cytochrome P450 enzymes: chemical mechanisms, structure-activity relationships and relationship to clinical drug-drug interactions and idiosyncratic adverse drug reactions

21 January 2018

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Role of hepatic and intestinal cytochrome P450 3A and 2B6 in the metabolism, disposition, and miotic effects of methadone

21 January 2018

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CYP induction-mediated drug interactions: in vitro assessment and clinical implications

21 January 2018

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Differential time course of cytochrome P450 2D6 enzyme inhibition by fluoxetine, sertraline, and paroxetine in healthy volunteers

21 January 2018

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Mechanism-based inhibition of human liver microsomal cytochrome P450 1A2 by zileuton, a 5-lipoxygenase inhibitor

21 January 2018

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Impact of Nonspecific Binding to Microsomes and Phospholipid on the Inhibition of Cytochrome P4502D6: Implications for Relating in Vitro Inhibition Data to in Vivo Drug Interactions

21 January 2018

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The utility of in vitro cytochrome P450 inhibition data in the prediction of drug-drug interactions

21 January 2018

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21 January 2018

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Carbamazepine: a 'blind' assessment of CVP-associated metabolism and interactions in human liver-derived in vitro systems

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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The impact of experimental design on assessing mechanism-based inactivation of CYP2D6 by MDMA (Ecstasy).

21 January 2018

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Kinetics of the time-dependent inactivation of CYP2D6 in cryopreserved human hepatocytes by methylenedioxymethamphetamine (MDMA).

21 January 2018

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In vitro-in vivo extrapolation of CYP2D6 inactivation by paroxetine: prediction of nonstationary pharmacokinetics and drug interaction magnitude

21 January 2018

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Drug-drug interactions via mechanism-based cytochrome P450 inactivation: points to consider for risk assessment from in vitro data and clinical pharmacologic evaluation

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Implications of mechanism-based inhibition of CYP2D6 for the pharmacokinetics and toxicity of MDMA.

21 January 2018

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Kinetic values for mechanism-based enzyme inhibition: assessing the bias introduced by the conventional experimental protocol.

21 January 2018

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Theoretical assessment of a new experimental protocol for determining kinetic values describing mechanism (time)-based enzyme inhibition

21 January 2018

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The effects of dose staggering on metabolic drug-drug interactions.

21 January 2018

1 reference

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10.1080/00498250701670945

21 January 2018

Identifiers

DOI

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17 August 2017

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