NMDA receptor regulation by D-serine: new findings and perspectives (Q36977786)

17 August 2017

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title

NMDA receptor regulation by D-serine: new findings and perspectives (English)

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17 August 2017

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Herman Wolosker

1

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PubMed ID

17952659

17 August 2017

language of work or name

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12 September 2007

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17 August 2017

Molecular Neurobiology

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17 August 2017

36

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17 August 2017

152-164

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17 August 2017

2

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https://scigraph.springernature.com/pub.10.1007/s12035-007-0038-6

17 August 2017

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Ketamine enhances the expression of serine racemase and D-amino acid oxidase mRNAs in rat brain

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Glia-derived D-serine controls NMDA receptor activity and synaptic memory

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D-serine is the dominant endogenous coagonist for NMDA receptor neurotoxicity in organotypic hippocampal slices.

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Distribution and MK-801-induced expression of serine racemase mRNA in rat brain by real-time quantitative PCR.

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Management of negative symptoms of schizophrenia

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Glycine tranporter-1 blockade potentiates NMDA-mediated responses in rat prefrontal cortical neurons in vitro and in vivo

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Further study on the specificity of D-amino acid oxidase and D-aspartate oxidase and time course for complete oxidation of D-amino acids

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Serine racemase binds to PICK1: potential relevance to schizophrenia

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12 December 2020

Serine racemase: a glial enzyme synthesizing D-serine to regulate glutamate-N-methyl-D-aspartate neurotransmission

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12 December 2020

Glutamate receptor activation triggers a calcium-dependent and SNARE protein-dependent release of the gliotransmitter D-serine

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12 December 2020

Endogenous D-serine is involved in induction of neuronal death by N-methyl-D-aspartate and simulated ischemia in rat cerebrocortical slices.

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12 December 2020

D-Serine as a glial modulator of nerve cells

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12 December 2020

Modulation of NMDA receptor-mediated responses by glycine and D-serine in the rat thalamus in vivo

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12 December 2020

Determination of free amino acid enantiomers in rat brain and serum by high-performance liquid chromatography after derivatization with N-tert.-butyloxycarbonyl-L-cysteine and o-phthaldialdehyde

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12 December 2020

Glycine decreases desensitization of N-methyl-D-aspartate (NMDA) receptors expressed in Xenopus oocytes and is required for NMDA responses.

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12 December 2020

Serine racemase modulates intracellular D-serine levels through an alpha,beta-elimination activity

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12 December 2020

Occurrence of pyridoxal 5'-phosphate-dependent serine racemase in silkworm, Bombyx mori

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12 December 2020

Changes in D-serine levels and localization during postnatal development of the rat vestibular nuclei

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12 December 2020

Decreased serum levels of D-serine in patients with schizophrenia: evidence in support of the N-methyl-D-aspartate receptor hypofunction hypothesis of schizophrenia.

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12 December 2020

D-Serine uptake by isolated retinas is consistent with ASCT-mediated transport

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12 December 2020

NMDA receptor pathways as drug targets

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12 December 2020

A glycine site associated with N-methyl-D-aspartic acid receptors: characterization and identification of a new class of antagonists

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D-serine as a neuromodulator: regional and developmental localizations in rat brain glia resemble NMDA receptors.

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12 December 2020

A critical role for the glial-derived neuromodulator D-serine in the age-related deficits of cellular mechanisms of learning and memory

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L-serine and glycine serve as major astroglia-derived trophic factors for cerebellar Purkinje neurons

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Paradigm shift in NMDA receptor antagonist drug development: molecular mechanism of uncompetitive inhibition by memantine in the treatment of Alzheimer's disease and other neurologic disorders.

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Glycine binding primes NMDA receptor internalization

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Novel neuroglial and glioglial relationships mediated by L-serine metabolism

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12 December 2020

Modulation of N-methyl-D-aspartate receptor function by glycine transport

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12 December 2020

Involvement of D-amino acid oxidase in elimination of D-serine in mouse brain

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12 December 2020

D-serine is an endogenous ligand for the glycine site of the N-methyl-D-aspartate receptor

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12 December 2020

D-serine enhances impaired long-term potentiation in CA1 subfield of hippocampal slices from aged senescence-accelerated mouse prone/8.

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Contribution of astrocytes to hippocampal long-term potentiation through release of D-serine.

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Immunohistochemical evidences for localization and production of D-serine in some neurons in the rat brain

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12 December 2020

Metabolism and functional roles of endogenous D-serine in mammalian brains

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12 December 2020

A kinetic analysis of the modulation of N-methyl-D-aspartic acid receptors by glycine in mouse cultured hippocampal neurones

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12 December 2020

Converging Evidence of NMDA Receptor Hypofunction in the Pathophysiology of Schizophrenia

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12 December 2020

Immunocytochemical analysis of D-serine distribution in the mammalian brain reveals novel anatomical compartmentalizations in glia and neurons.

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12 December 2020

Glycine and N-methyl-D-aspartate receptors: physiological significance and possible therapeutic applications.

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12 December 2020

Measuring D-serine efflux from mouse cortical brain slices using online microdialysis-capillary electrophoresis.

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12 December 2020

The role of glutamate neurotoxicity in hypoxic-ischemic neuronal death

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12 December 2020

Mice with reduced NMDA receptor expression display behaviors related to schizophrenia

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12 December 2020

Mice lacking D-amino acid oxidase activity display marked attenuation of stereotypy and ataxia induced by MK-801.

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12 December 2020

Allosteric regulation of mouse brain serine racemase

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12 December 2020

Measuring the effect of glutamate receptor agonists on extracellular D-serine concentrations in the rat striatum using online microdialysis-capillary electrophoresis

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12 December 2020

Immunohistochemical demonstration of L-serine distribution in the rat brain

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12 December 2020

Synthesis and release of L-serine by rat astroglia-rich primary cultures

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12 December 2020

Glycine uptake governs glycine site occupancy at NMDA receptors of excitatory synapses.

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12 December 2020

Substitution of pyridoxal 5'-phosphate in D-serine dehydratase from Escherichia coli by cofactor analogues provides information on cofactor binding and catalysis

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12 December 2020

Slow-binding human serine racemase inhibitors from high-throughput screening of combinatorial libraries.

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12 December 2020

Reverse Na+/Ca2+ exchange contributes to glutamate-induced intracellular Ca2+ concentration increases in cultured rat forebrain neurons.

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12 December 2020

Purification of serine racemase: biosynthesis of the neuromodulator D-serine

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12 December 2020

Serine racemase: activation by glutamate neurotransmission via glutamate receptor interacting protein and mediation of neuronal migration

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12 December 2020

The GluR2 (GluR-B) hypothesis: Ca(2+)-permeable AMPA receptors in neurological disorders

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12 December 2020

Glutamate-mediated astrocyte-neuron signalling

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12 December 2020

Cofactors of serine racemase that physiologically stimulate the synthesis of the N-methyl-D-aspartate (NMDA) receptor coagonist D-serine

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12 December 2020

Rat cerebral serine racemase: amino acid deletion and truncation at carboxy terminus

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12 December 2020

Extracellular concentration of endogenous free D-serine in the rat brain as revealed by in vivo microdialysis

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12 December 2020

Glial transport of the neuromodulator D-serine

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12 December 2020

Neuron-derived D-serine release provides a novel means to activate N-methyl-D-aspartate receptors.

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12 December 2020

Human serine racemase: moleular cloning, genomic organization and functional analysis

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12 December 2020

A CSF and postmortem brain study of D-serine metabolic parameters in schizophrenia

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12 December 2020

Gene knockout of glycine transporter 1: characterization of the behavioral phenotype

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12 December 2020

Selectivity of quinoxalines and kynurenines as antagonists of the glycine site on N-methyl-D-aspartate receptors

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12 December 2020

Induction of serine racemase expression and D-serine release from microglia by amyloid beta-peptide

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12 December 2020

A new strategy to decrease N-methyl-D-aspartate (NMDA) receptor coactivation: inhibition of D-serine synthesis by converting serine racemase into an eliminase

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12 December 2020

Recent advances in the phencyclidine model of schizophrenia

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12 December 2020

Mechanisms of activation, inhibition and specificity: crystal structures of the NMDA receptor NR1 ligand-binding core

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12 December 2020

Direct calcium binding results in activation of brain serine racemase

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12 December 2020

The presence of free D-serine in rat brain

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12 December 2020

Direct signaling from astrocytes to neurons in cultures of mammalian brain cells.

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12 December 2020

D-serine, an endogenous synaptic modulator: localization to astrocytes and glutamate-stimulated release

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12 December 2020

New insights into neuron-glia communication

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12 December 2020

d -serine and serine racemase are present in the vertebrate retina and contribute to the physiological activation of NMDA receptors

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12 December 2020

D-serine added to antipsychotics for the treatment of schizophrenia

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12 December 2020

Reduced D-serine to total serine ratio in the cerebrospinal fluid of drug naive schizophrenic patients

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12 December 2020

Neurobiology through the looking-glass: D-serine as a new glial-derived transmitter

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12 December 2020

Novel neurotransmitters and their neuropsychiatric relevance

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12 December 2020

D-amino-acid oxidase is confined to the lower brain stem and cerebellum in rat brain: regional differentiation of astrocytes

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12 December 2020

Identification of multiple serine racemase (SRR) mRNA isoforms and genetic analyses of SRR and DAO in schizophrenia and D-serine levels

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12 December 2020

Induction of serine racemase by inflammatory stimuli is dependent on AP-1

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12 December 2020

Depletion of cerebral D-serine in non-ketotic hyperglycinemia: possible involvement of glycine cleavage system in control of endogenous D-serine.

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12 December 2020

Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia

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12 December 2020

Glycine potentiates the NMDA response in cultured mouse brain neurons

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12 December 2020

The emerging role of glutamate in the pathophysiology and treatment of schizophrenia

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12 December 2020

The origin and turnover of D-serine in brain.

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12 December 2020

In vivo evidence for the link between L- and D-serine metabolism in rat cerebral cortex.

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12 December 2020

Modulation of D-serine levels via ubiquitin-dependent proteasomal degradation of serine racemase

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12 December 2020

D-serine efficacy as add-on pharmacotherapy to risperidone and olanzapine for treatment-refractory schizophrenia

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12 December 2020

Fluorescent detection of Ca2+-permeable AMPA/kainate receptor activation in murine neocortical neurons

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12 December 2020

Mouse brain serine racemase catalyzes specific elimination of L-serine to pyruvate

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12 December 2020

High affinity D- and L-serine transporter Asc-1: cloning and dendritic localization in the rat cerebral and cerebellar cortices

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12 December 2020

Exaggerated responses to chronic nociceptive stimuli and enhancement of N-methyl-D-aspartate receptor-mediated synaptic transmission in mutant mice lacking D-amino-acid oxidase

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12 December 2020

In vivo modulation of the N-methyl-D-aspartate receptor complex by D-serine: potentiation of ongoing neuronal activity as evidenced by increased cerebellar cyclic GMP

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12 December 2020

Requirement for glycine in activation of NMDA-receptors expressed in Xenopus oocytes

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12 December 2020

Monitoring D-serine dynamics in the rat brain using online microdialysis-capillary electrophoresis

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12 December 2020

Glycine and D-serine increase the affinity of N-methyl-D-aspartate sensitive glutamate binding sites in rat brain synaptic membranes

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12 December 2020

Functional comparison of D-serine and glycine in rodents: the effect on cloned NMDA receptors and the extracellular concentration.

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12 December 2020

10.1007/S12035-007-0038-6

Identifiers

DOI

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17 August 2017

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PubMed ID

17952659